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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 14 (1998), S. 275-286 
    ISSN: 1435-5663
    Keywords: Computer-aided design of buildings ; Database management system ; Hierarchical index ; Object-oriented model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract An effective database and database management system is the key to the success of an integrated approach to software engineering applications in general, and Computer-Aided Design (CAD) for structural applications in particular. Due to the inherent nature of CAD data such as dynamic modeling, a wide range of data types, large data volume, etc., the traditional database models, such as hierarchical, network and relational models, are unable to handle the aforementioned applications satisfactorily. An object-oriented data modeling is known to be the most effective approach. However, many of the commercial object-oriented databases are designed for information management, and they are inadequate for CAD application due to the different features of the object-hierarchy and varying data management objectives during the design cycles. This paper presents a hierarchical index-based object-oriented database management model for CAD applications. To deal with the object hierarchy encountered in CAD for the design of tall buildings, the proposed database consists of several salient features: a hierarchical object model, its related storage structure, a data dictionary, a class factory and an index system. The proposed database management model has been implemented into an integrated CAD system for design application of tall buildings.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Nonlinear dynamics 16 (1998), S. 337-347 
    ISSN: 1573-269X
    Keywords: Friction oscillator ; friction estimation ; friction identification ; Coulomb friction ; free vibration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This study focuses on an algorithm for the simultaneous identification of Coulomb and viscous damping effects from free-vibration decrements in a damped linear single degree-of-freedom (DOF) mass-spring system. Analysis shows that both damping effects can indeed be separated. Numerical study of a combined-damping system demonstrates a perfect match between the simulation parameters and the estimated values. Experimental study includes two types of real systems. The method is applied to an experimental industrial bearing. Experimental results are compared with numerical simulations to illustrate the reliability of this method. An analysis provides conservative bounds on error estimates. An example of the effect of quantization error on the estimations is included.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2016-03-19
    Description: Rationale: The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies for optimizing stem-cell–based myocardial therapy are needed. Objective: The present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) are more effective than MSCs cultured under ambient oxygen levels for the treatment of myocardial injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation. Methods and Results: MSCs were engineered to express green fluorescent protein, cultured under ambient oxygen or 0.5% oxygen (HP-MSCs) for 24 hours and then tested in the infarcted hearts of Cynomolgus monkeys (1 x 10 7 cells per heart). Hypoxia preconditioning increased the expression of several prosurvival/proangiogenic factors in cultured MSCs, and measurements of infarct size and left-ventricular function at day 90 after myocardial infarction were significantly more improved in monkeys treated with HP-MSCs than in monkeys treated with the control vehicle; functional improvements in normal cultured bone marrow mesenchymal stem cells–treated monkeys were not significant. HP-MSCs transplantation was also associated with increases in cardiomyocyte proliferation, vascular density, myocardial glucose uptake, and engraftment of the transplanted cells and with declines in endogenous cell apoptosis, but did not increase the occurrence of arrhythmogenic complications. Conclusions: Hypoxia preconditioning improved the effectiveness of MSCs transplantation for the treatment of myocardial infarction in nonhuman primates without increasing the occurrence of arrhythmogenic complications, which suggests that future clinical trials of HP-MSCs transplantation are warranted.
    Keywords: Basic Science Research, Cell Therapy, Stem Cells, Myocardial Infarction
    Print ISSN: 0009-7330
    Electronic ISSN: 1524-4571
    Topics: Medicine
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