ISSN:
1432-1106
Keywords:
Axon
;
Protein
;
Flow
;
Optic nerve
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Two experiments have been performed to gain insight into the mechanisms of axoplasmic protein migration. In the first the concentration of protein along cat optic nerves was measured to determine if a concentration gradient was present which might drive protein in a proximo-distal direction. None was found. In the second experiment we endeavored to determine if axonal protein migration would continue despite cycloheximide-induced inhibition of protein synthesis in the cell body. It did continue to migrate and with no significant change in rate (0.8–1.0 mm/day). It is concluded that these experiments rule out diffusion down a proximo-distal concentration gradient as a mechanism for axonal protein migration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00240359
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