ISSN:
1573-2592
Keywords:
T-cell subsets
;
autologous mixed lymphocyte reaction
;
interleukin-2 (IL-2)
;
IL-2 receptor
;
suppressor function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In this study we have demonstrated that in the T-TA autologous mixed lymphocyte reaction (AMLR), OKT4+ T cells are the major responders; however, in the presence of additional interleukin-2 (IL-2), OKT8+ T cells also respond by proliferation. Both OKT4+ and OKT8+ T cells, activated in the T-non-T AMLR, act as stimulators in the T-TA AMLR. OKT4+ T cells activated in the T-TA AMLR suppress the proliferative response of the fresh T-non-T AMLR; control OKT4+ cells show no immunoregulatory activity in this system. In contrast, control OKT8+ T cells spontaneously suppress the proliferation of the T-non-T AMLR, but activation of OKT8+ T cells in the T-TA AMLR does not result in a further increase in the suppressor activity of OKT8+ T cells. In summary, in the T-non-T and T-TA AMLR phenotypically similar T-cell subpopulations proliferate but express distinct immunoregulatory functions and perhaps regulate the tempo of the AMLR.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00915510
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