GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    17. Konservative therapie der hyperthyreose vom Typ M. Basedow (indikation und taktik) (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 131-136 
    Details
    ISSN: 1435-2451
    Keywords: Autoimmunology ; Antithyroid substances ; Steroid hormones ; Radioactive iodine ; Immunpathogenese ; Steroidbehandlung ; Antithyreoidale Substanzen ; Radiojodtherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Spezielle Behandlungsmaßnahmen sind 1. Stoßartig Steroidhormone, 2. Antithyreoidale Substanzen, 3. Radiojod, 4. Strumaresektion. Die ersten beiden sind passagere Verfahren und ergänzen die definitiven nuklearmedizinischen und operativen Behandlungsmaßnahmen. Differentialtherapeutische Erwägungen knüpfen sich an Lebensalter und Kropfgröße. Für ca. 60 % aller Fälle ist die Radiojodtherapie optimal, je größer eine hyperthyreotische Struma, desto eher ist die Operation indiziert. Detaillierte Gesichtspunkte werden anhand von 3580 eigenen Fällen von Hyperthyreose erörtert.
    Notes: Summary Special procedures are: (1) Short-term treatment with steroid hormones; (2) antithyroid substances; (3) radioactive iodine; (4) operation. The first two methods are complementary to the definitive procedures of isotope and surgical therapy. The indications conform to the age of the patient and the size of the goiter. The treatment of choice in 60 % of all cases is radioactive iodine; 20–25 % are treated with antithyroid substances only for several years. The remaining cases, complicated by goiters of size II and more, should be handled surgically. Discussion based on personal experience with 3580 cases over 20 years).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579318
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Prophylactic intervention in radiation-leukemia-virus-induced murine lymphoma by the biological response modifier polysaccharide K (1995)
    Springer
    Cancer immunology immunotherapy 41 (1995), S. 389-396 
    Details
    ISSN: 1432-0851
    Keywords: RadLV ; Lymphoma ; PSK ; Superantigen ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Polysaccharide K (PSK) is a biological response modifier used for adjuvant immunotherapy of malignant diseases. We studied the potential applicability of PSK for preventing tumor progression using an experimental model of murine lymphoma. Mice inoculated with the radiation leukemia virus (RadLV) develop thymic lymphomas after a latency of 3–6 months. However, 2 weeks after virus inoculation, prelymphoma cells can already be detected in the thymus. We found that PSK treatment induced hyperresponsiveness to concanavalin A and heightened production of interleukin-2 (IL-2) and IL-4 in spleen cells of both control and prelymphoma mice. The response was transient and was accompanied with a dominant usage of T cells expressing Vβ8, but other T cell subsets were also stimulated by PSK. T lymphoma cells expressing Vβ8.2 underwent apoptosis when incubated with PSK. Treatment of RadLV-inoculated mice with PSK delayed the onset of overt lymphoma (and mortality) but could not protect the mice from the disease. Combined treatment with PSK and a RadLV-specific immunotoxin prevented synergistically the progression of the prelymphoma cells to frank lymphoma. The results suggest that PSK contains a superantigen-like component that selectively activates Vβ8+ T cells. Its administration prelymphoma mice interfered with the process of lymphoma progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526559
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Prophylactic intervention in radiation-leukemia-virus-induced murine lymphoma by the biological response modifier polysaccharide K (1996)
    Springer
    Cancer immunology immunotherapy 41 (1996), S. 389-396 
    Details
    ISSN: 1432-0851
    Keywords: Key words RadLV ; Lymphoma ; PSK ; Superantigen ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Polysaccharide K (PSK) is a biological response modifier used for adjuvant immunotherapy of malignant diseases. We studied the potential applicability of PSK for preventing tumor progression using an experimental model of murine lymphoma. Mice inoculated with the radiation leukemia virus (RadLV) develop thymic lymphomas after a latency of 3 – 6 months. However, 2 weeks after virus inoculation, prelymphoma cells can already be detected in the thymus. We found that PSK treatment induced hyperresponsiveness to concanavalin A and heightened production of interleukin-2 (IL-2) and IL-4 in spleen cells of both control and prelymphoma mice. The response was transient and was accompanied with a dominant usage of T cells expressing Vβ8, but other T cell subsets were also stimulated by PSK. T lymphoma cells expressing Vβ8.2 underwent apoptosis when incubated with PSK. Treatment of RadLV-inoculated mice with PSK delayed the onset of overt lymphoma (and mortality) but could not protect the mice from the disease. Combined treatment with PSK and a RadLV-specific immunotoxin prevented synergistically the progression of the prelymphoma cells to frank lymphoma. The results suggest that PSK contains a superantigen-like component that selectively activates Vβ8+ T cells. Its administration prelymphoma mice interfered with the process of lymphoma progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526559
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...