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  • 1
    Electronic Resource
    Electronic Resource
    A comparison of trazodone and fluoxetine: implications for a serotonergic mechanis of antidepressant action (1992)
    Springer
    Psychopharmacology 109 (1992), S. 2-11 
    Details
    ISSN: 1432-2072
    Keywords: Trazodone ; Fluoxetine ; 5-HT2 antagonists ; 5-HT uptake inhibitors ; Serotonin ; Atypical antidepressants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Trazodone is an atypical antidepressant drug that is commonly referred to as a serotonin (5-hydroxytryptamine; 5-HT) uptake inhibitor. However, the most potent pharmacological effect of trazodone appears to be antagonist action at 5-HT2/1C receptors. This is in contrast to fluoxetine, for which inhibition of 5-HT uptake is the most potent pharmacological action. The effects of trazodone and fluoxetine on several antidepressant drug screens are mediated by antagonist action at 5-HT2 receptors and inhibition of 5-HT uptake, respectively. While fluoxetine is an effective agent for the treatment of major depression, obsessive-compulsive disorder (OCD) and panic disorder, trazodone does not appear to be effective in the treatment of OCD and panic disorder. In addition, trazodone and fluoxetine differ in humans with respect to their effects on sleep and weight. Taken together, the preclinical and clinical data suggest that trazodone acts as an antidepressant via antagonist action at 5-HT2/1C receptors, while fluoxetine likely acts as an antidepressant via inhibition of 5-HT uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245475
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity (1991)
    Springer
    Psychopharmacology 105 (1991), S. 453-458 
    Details
    ISSN: 1432-2072
    Keywords: Mianserin ; Atypical antidepressants ; DRL 72-s schedule ; Serotonin ; 5-HT2 receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioral effects of racemic mianserin, its (+) and (−) enantiomers, and its metabolites desmethylmianserin and 8-hydroxymianserin were evaluated on the differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule, a screen known to be sensitive to and specific for the antidepressant properties of drugs. Racemic mianserin produced the antidepressant-like effect (increased reinforcement rate, decreased response rate) at 5 and 10 mg/kg. The mianserin enantiomers showed the antidepressant-like effect beginning at lower doses [(+) mianserin; 0.6 mg/kg; (−) mianserin: 2.5 mg/kg]. The mianserin metabolites showed no clear dose-related effect at doses up to 10 mg/kg. It is concluded that the antidepressant-like effects of mianserin are due to the activity of the parent compound rather than to its metabolites, and that they may be primarily attributable to the (+) enantiomer. The greater potency of (+)-mianserin may be related to its higher affinity for the 5-HT2 receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244363
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
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