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  • metastasis  (2)
  • Atlases  (1)
  • CT; DATE/TIME; DEPTH, water; Fluorescence; LATITUDE; LONGITUDE; Maria S. Merian; MSM49; MSM49-track; Salinity; Temperature, water; Underway cruise track measurements  (1)
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  • 1
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg
    Keywords: Medicine ; Gynecology ; Oncology ; Surgery ; Medicine & Public Health ; Gynecology ; Oncology ; Surgery ; Medicine ; Breast surgery ; Atlases ; Mamma ; Krankheit ; Chirurgie ; Mamma ; Plastische Chirurgie
    Description / Table of Contents: Unique atlas on the market that covers both surgical management of breast diseases and cosmetic reconstructionInternational technical standard set by the world's best surgeonsAbundantly illustrated Ismail Jatoi, MD., Head of the National Capital Area Breast Cancer, National Navel Medical Center, Bethesda, USAManfred Kaufmann, MD., Professor and Head ofthe Department of Obstetrics and Gynecology, Goethe University, Frankfurt, Germany.Jean Ives Petit, MD., Professor and Head of the Department of Plastic Surgery, European Institut of Oncology, Milano.
    Type of Medium: Online Resource
    Pages: Online-Ressource (X, 133 p. 132 illus, digital)
    ISBN: 9783540294924
    Series Statement: SpringerLink
    RVK:
    RVK:
    Language: English
    Note: Includes bibliographical references and index , CONTENTS; Chapter 1; Historical Overview of Breast Surgery Chapter; Chapter 2; Anatomy; Chapter 3; Diagnostic Procedures; Chapter 4; Surgery for Benign Breast Diseases; Chapter 5; Biopsy Procedures; Chapter 6; Surgery for Breast Carcinoma; Chapter 7; Plastic and Reconstructive Breast Surgery; Subject Index
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  • 2
    Publication Date: 2024-02-02
    Keywords: CT; DATE/TIME; DEPTH, water; Fluorescence; LATITUDE; LONGITUDE; Maria S. Merian; MSM49; MSM49-track; Salinity; Temperature, water; Underway cruise track measurements
    Type: Dataset
    Format: text/tab-separated-values, 115960 data points
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  • 3
    ISSN: 1573-7217
    Keywords: breast cancer ; CD44 variants ; metastasis ; tumor progression marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Splice variants of CD44 expressed in a metastasizing cell line derived from a rat pancreatic adenocarcinoma have been shown recently to confer metastatic potential onto non-metastasizing rat pancreatic carcinoma and sarcoma cell lines. Homologues of these variants have also been detected in a variety of human malignancies. Using antibodies raised against a bacterially expressed fusion protein containing variant CD44 sequences, we have explored the expression of variant CD44 glycoproteins on tumors of the female breast. The material examined included normal tissue, hyperplastic lesions, 103 primary invasive mammary carcinomas, 10in situ carcinomas, 12 local recurrences and 18 lymph node metastases. Using a polyclonal serum directed against several variant CD44 epitopes, normal mammary epithelia as well as ductal hyperplasias were negative for these splice variants, while the variant CD44 epitopes were detectable in all but six of the primary invasive carcinomas. From the reaction with various monoclonal antibodies and polyclonal sera specific for individual epitopes it is obvious that the tumors predominantly express CD44 variants encoded by exons v5 to v7. Interestingly, all investigated lymph node metastases reacted positively with the variant-specific antibodies, in contrast to primary tumors which reacted in 54% to 86% of the cases, depending on the antibody used. Statistical analysis revealed a significant correlation between expression of variant exons v3/v4 and v6 and increased tumor grade (p = 0.001 and p 〈 0.05, respectively; Fisher's exact test). Exon v6 is carried by the variants which confer metastatic capability in the rat. These results indicate that the expression of the CD44 variants is upregulated in mammary carcinomas and is closely linked to tumor anaplasia.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7276
    Keywords: metastasis ; microvessel density ; ovarian carcinoma ; proto-oncogenes ; resistance-related proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Relationships between the incidence of metastatic spread and microvessel density, expression of proto-oncogene products, or expression of resistance-related proteins were investigated in human ovarian carcinomas by immunohistochemistry. Ovarian carcinomas with a high microvessel density showed a significantly increased formation of metastases (P=0.005). Tumors with positive immunoreactivity of c-jun and c-myc products had a higher metastatic spread; however, these results were not statistically significant. A marginally significant correlation existed between the expression of erbB1 (EGFR) and metastatic spread (P=0.05). No significant relationship was found between the expression of the resistance-related proteins P-glycoprotein or glutathione S-transferase-π and the incidence of metastases. Furthermore, no correlation was detected between expression of the heat shock protein 70 and the occurrence of metastases.
    Type of Medium: Electronic Resource
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