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  • 1
    Electronic Resource
    Electronic Resource
    Characterization and phylogenetic distribution of a chloroplast DNA rearrangement in theBerberidaceae (1994)
    Springer
    Plant systematics and evolution 193 (1994), S. 107-114 
    Details
    ISSN: 1615-6110
    Keywords: Berberidaceae ; Berberis ; Mahonia higginsae ; Chloroplast DNA (cpDNA) ; Inverted Repeats (IR)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Restriction site maps and a clone bank of chloroplast DNA (cpDNA) ofMahonia higginsae (Munz)Ahrendt (Berberidaceae) were constructed. The size ofMahonia cpDNA was about 167 kb. Precise mapping using gene probes revealed that cpDNA ofM. higginsae has an inverted repeat (IR) 11.5 kb larger than the tobacco IR. The expansion of the IR into the large single copy region has resulted in the duplication of at least ten genes includingpsbB. The phylogenetic distribution of the expanded IR was examined in twenty-five species ofBerberis andMahonia, twenty species representing the fifteen remaining genera of theBerberidaceae, and four species from four allied families. Our survey indicates that only the species of the closely related generaBerberis andMahonia share the 11.5kb expansion of IR. This result supports their close phylogenetic relationship, which has been suggested previously by chromosomal, morphological, and serological data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00983544
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    Paper (German National Licenses)
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  • 2
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    Clinical Implications and Determinants of Left Atrial Mechanical Dysfunction in Patients With Stroke [Clinical Sciences] (2016)
    American Heart Association (AHA)
    In: Stroke
    Details
    Publication Date: 2016-05-24
    Description: Background and Purpose— The evaluation of sources of cardioembolism with transesophageal echocardiography (TEE) in patients with stroke is crucial but semi-invasive. We hypothesized that the size and mechanical function of the left atrium (LA) assessed by transthoracic echocardiography (TTE) could provide useful information on high risk of cardioembolism on TEE in patients with stroke. Furthermore, we sought to define the determinants of LA mechanical dysfunction in these patients. Methods— A total of 248 patients with acute ischemic stroke (147 men; 64±13 years) who underwent 2-dimensional and speckle tracking TTE followed by TEE were analyzed. Results— LA appendage emptying velocity, prevalence of LA or LA appendage thrombus, prevalence of aortic plaques, and incidence of embolic stroke showed significant differences among the 4 groups classified according to the median values of the LA volume index and global LA longitudinal strain (LALS). Patients at high risk of cardioembolism evidenced by TEE revealed significantly larger LA volume index and lower global LALS than those without. Global LALS (cutoff, 11.5%; area under the curve, 0.947; sensitivity, 100%; specificity, 91%; P 〈0.001) revealed a significantly better diagnostic power ( P =0.04) for LA or LA appendage thrombus than LA volume index (cutoff, 36.2 mL/m 2 ; area under the curve, 0.823; sensitivity, 88%; specificity, 75%; P =0.002). Age, left ventricular systolic function, LA volume index, and pulse wave velocity were independent determinants for global LALS. Conclusions— LA mechanical dysfunction is closely associated with high risks of cardioembolism. Global LALS assessed by speckle tracking TTE well discriminates the presence of LA or LA appendage thrombus on TEE in patients with acute ischemic stroke.
    Keywords: Echocardiography, Cerebrovascular Disease/Stroke, Ischemic Stroke
    Print ISSN: 0039-2499
    Electronic ISSN: 1524-4628
    Topics: Medicine
    Published by American Heart Association (AHA)
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  • 3
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    Time-Dependent Thrombus Resolution After Tissue-Type Plasminogen Activator in Patients With Stroke and Mice [Clinical Sciences] (2015)
    American Heart Association (AHA)
    In: Stroke
    Details
    Publication Date: 2015-06-23
    Description: Background and Purpose— We investigated the relationship between the degree of thrombus resolution and the time from stroke onset or thrombus formation to intravenous tissue-type plasminogen activator (tPA) treatment. Methods— In patients with stroke, we measured thrombus volume on thin-section noncontrast brain computed tomographic scans taken at baseline and 1 hour after tPA administration. We determined the association between the time from symptom onset to tPA treatment and the degree of thrombus resolution. In a C57/BL6 mouse model of FeCl 3 -induced carotid artery thrombosis, we investigated the effect of tPA administered at different time intervals after thrombus formation, using Doppler-based blood flow measurement. Results— Of 249 patients enrolled, 171 showed thrombus on baseline computed tomography. Thrombus was resolved by ≥50% in 43 patients (25.1%, good volume reduction) and by 〈50% in 94 patients (55.0%, moderate volume reduction) 1 hour after tPA treatment. In 34 patients (19.9%, nonvolume reduction; either no change or thrombus volume increased), overall thrombus volume increased. The probability of thrombus resolution decreased as the time interval from symptom onset to treatment increased. On multivariate analysis, good volume reduction was independently related with shorter time intervals from symptom onset to tPA treatment (odds ratio, 0.986 per minute saved; 95% confidence interval, 0.974–0.999). In the mouse model, as the interval between thrombus formation and tPA treatment increased, the initiation of recanalization was delayed ( P =0.006) and the frequency of final recanalization decreased ( P for trends=0.006). Conclusions— Early administration of tPA after stroke onset is associated with better thrombus resolution.
    Keywords: Arterial thrombosis, Acute Cerebral Infarction, Thrombolysis
    Print ISSN: 0039-2499
    Electronic ISSN: 1524-4628
    Topics: Medicine
    Published by American Heart Association (AHA)
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