ISSN:
1434-0879
Keywords:
Aromatization
;
BPH
;
Prostate cancer
;
Prostatic secretions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Human prostatic tissue and expressed prostatic secretions (EPS) efrom patients with benign prostatic hyperplasia (BPH) and prostate cancer were incubated with (1 β 3H) androstenedione. The extent of aromatization was determined by measuring the transfer of 3H from the 1 β position into water. The amount of 3H2O recovered corresponds to the estrogens formed. Tissue from 5 patients with BPH yielded 2.13 (±1.05) pmol/mg protein/h while the EPS from the same patients yielded 727 fmol/mg protein/h. In patients with prostate cancer the mean formation of estrogens was 388 fmol/mg protein/h (±75). 4-hydroxyandrostenedione, an aromatase inhibitor, successfully inhibited aromatization in BPH and prostate cancer 53–98%.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00254430
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