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  • 1
    Electronic Resource
    Electronic Resource
    The influence of the p53 gene on the in vitro chemosensitivity of colorectal cancer cells (1999)
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 357-360 
    Details
    ISSN: 1432-1335
    Keywords: Key words Colorectal neoplasms ; Apoptosis ; Chemosensitivity ; p53 gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose : The p53 gene is considered one of the most important in the control of apoptosis, and its mutations have a close relationship with chemosensitivity. The aim of this work was to investigate the role of p53 in the apoptosis of colorectal cancer cells in vitro, induced by 5-fluorouracil (5-FU) and hydroxy-camptothecin (HCPT). Methods : A total of 39 colorectal cancer samples from patients were treated in vitro with 5-FU (10 μg/ml), 5-FU (10 μg/ml) + leucovorin (5 μg/ml), HCPT (0.1 μg/ml) and HCPT (0.1 μg/ml) + Salvia mitorrhiza (6 μl), using an in situ terminal deoxynucleotidyltransferase assay to detect chemosensitivity. p53 gene mutations from tumor DNA were detected, after amplification by the polymerase chain reaction of exons 5–8, by non-radioactive single-strand conformation polymorphism. Results : p53 gene mutations were observed in 43.6% (17/39) of colorectal carcinomas, when the terminal deoxynucleotidyltransferase assay was used to detect the tumor apoptotic rate. Cells with mutated p53 had lower chemosensitivity than those without (p 〈 0.01). Conclusion : Routine assessment of p53 status may be helpful in selecting patients with the wild-type p53 gene, who have a predictably better response to chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050286
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  • 2
    Electronic Resource
    Electronic Resource
    Impact-Induced delamination in [05, 905, 05] carbon fiber/polyetheretherketone composite laminates (1991)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 31 (1991), S. 1301-1309 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This paper reports both experimental and numerical investigations on delamination mechanisms in [05, 905, 05] carbon fiber(CF)/poly(etheretherketone) (PEEK) laminate subjected to low-velocity impact. It was found that the CF/PEEK composite exhibits the same damage mechanisms as epoxy-based composites, but superior delamination resistance. For the crossply laminate, the impact delamination results from a Mode II interlaminar fracture process, and a close association exists between the interlaminar shear stress field and the delamination growth. The prediction of impact-induced delamination sizes is discussed.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760311804
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    Paper (German National Licenses)
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