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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 9 (1994), S. 334-337 
    ISSN: 1437-9813
    Keywords: Gastroesophageal reflux ; Antireflux procedure ; Nissen fundoplication ; Thal fundoplication ; Complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Nissen fundoplication has been the most commonly used procedure in the surgical management of reflux esophagitis. Due to unsatisfactory results and the many complications of the Nissen procedure, in 1989 we began using the Thal partial wrap. In a retrospective study, the results from both procedures are compared. Between August 1982 and May 1991, antireflux operations (27 Nissen; 23 Thal) were performed in 44 children. Fifty-eight percent had associated conditions, neurological impairment (12) and esophageal atresia being the most frequent. An uneventfull postoperative course was seen in 29.6% after the Nissen fundoplication and 87% in the Thal group (P 〈0.5). Recurrence or persistence of gastroesophageal reflux was observed in 37% and 4% of the Nissen and Thal groups, respectively. The symptom-free interval following the antireflux procedure averaged 11 months in the Nissen group and 2.8 months in the Thal group. Three out of 4 neurologically impaired children with a Nissen fundoplication had postoperative complications compared to 2 out of 8 with a Thal partial wrap. Eight children, all with a Nissen fundoplication, had to be reoperated for either acute obstruction or a redo procedure. The mean hospitalization times for the Nissen and Thal procedures were 16 and 7.6 days, respectively (P 〈0.1). From our experience, the Thal partial fundoplication appears to be an effective antireflux procedure with fewer perioperative complications than the Nissen operation. In the neurologically impaired child with feeding problems and reflux, a Thal fundoplication in combination with a gastrostomy is our therapy of choice.
    Type of Medium: Electronic Resource
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  • 2
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    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2017-08-18
    Description: Vinculin is an actin-binding protein thought to reinforce cell-cell and cell-matrix adhesions. However, how mechanical load affects the vinculin–F-actin bond is unclear. Using a single-molecule optical trap assay, we found that vinculin forms a force-dependent catch bond with F-actin through its tail domain, but with lifetimes that depend strongly on the direction of the applied force. Force toward the pointed (–) end of the actin filament resulted in a bond that was maximally stable at 8 piconewtons, with a mean lifetime (12 seconds) 10 times as long as the mean lifetime when force was applied toward the barbed (+) end. A computational model of lamellipodial actin dynamics suggests that the directionality of the vinculin–F-actin bond could establish long-range order in the actin cytoskeleton. The directional and force-stabilized binding of vinculin to F-actin may be a mechanism by which adhesion complexes maintain front-rear asymmetry in migrating cells.
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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