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  • Schlüsselwörter Atemgasklimatisierung  (2)
  • Antibiotikatherapie  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 46 (1997), S. 613-615 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Atemgasklimatisierung ; Narkosegerät ; PhysioFlex ; Geschlossenes System ; Key words Climatisation of anaesthetic gases ; Anaesthesia machine ; PhysioFlex ; Closed system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The PhysioFlex anaesthesia machine is designed to operate as a quantitative closed system. The gas in the system is circulated at 70 litres per minute. With its small soda lime canister and the integration of all components in a thermal insulating case it fulfils all prerequisites for excellent climatisation of the anaesthetic gases. The extent of warming and humidifying of the anaesthetic gases was monitored during extended neurosurgical operations using long tubes to the patient (3 m each) in an cold operating room (17–18 °C). Material and Methods: The time course of the temperature and the humidity of the inspired gases was analysed in six patients undergoing intracranial surgery [three male, three female; age 58,8±9.5 years; body weight 78.8±11.5 kg; duration 247.5±63.38 min (mean±SD)]. A capacitive humidity sensor (Vaisala, type HMM 30D) and a very small platinum resistor (Sensycon, type GR42105) were used to measure, at 5-min intervals, the relative humidity (rH) and temperature (T) of the gases in the inspiratory limb close to the Y-piece. At that position in the continuous gas stream, humidity and temperature are not dependent on the single breath but change gradually. With the temperature-dependent humidity content of 100% rH absolute humidity was calculated [6]. Results: Within 10 min 100% rH was achieved. Then humidity changes were only temperature dependent. Figure 1 shows the time course of mean inspiratory temperature and mean absolute humidity (mean±SD). After 30 min an average of 20 mg H2O/l gas was achieved. Analysing the single recordings, 20 mg/l was achieved between the 15th and 80th min. Steady state was reached after about 150 min at a level of more than 24 °C or more than 21.7 mg H2O/l. As demonstrated in the figure, a change of the soda lime canister (285th min) caused a marked decrease of inspiratory temperature and humidity. Conclusions: The climatisation of anaesthetic gases was faster and reached a higher level with the PhysioFlex than has been reported with conventional anaesthesia machines. Even under these environmental conditions – a cold operating room and long tubing allowing great heat loss to the environment – minimal climatisation of 20 mgH2O/l was reached within 30 min. The fast climatisation seems to be due to the operating principle, revolving the system volume with 70 l/min. This causes optimal usage of the heat and humidity generated by CO2 absorption in the soda lime, documented by the strong influence on climatisation of soda lime changes.
    Notes: Zusammenfassung Am Narkosegerät PhysioFlex wurde die Klimatisierung des Atemgases bei langdauernden intrakraniellen Eingriffen untersucht. Methoden: Das Narkosegerät wurde im quantitativ geschlossenen System betrieben. Die inspiratorische Atemgastemperatur und die relative Feuchte wurden an einer Meßstelle kurz vor dem Y-Stück bestimmt. Ergebnisse: Trotz ungünstiger Bedingungen wie kalter OP-Saal (17–18 °C) und lange Beatmungsschläuche, die eine große Wärmeabgabe an die Umgebung ermöglichen, konnte im Mittel nach 30 min wasserdampfgesättigtes Atemgas mit mehr als 20 mg H2O/l gemessen werden. Nach ca. 150 min stabilisierte sich die inspiratorische Atemgastemperatur im Mittel zwischen 24 und 25 °C entsprechend einer inspiratorischen Feuchte von 21,7 bis 23,3 mg H2O/l. Schlußfolgerung: Der selbst unter diesen ungünstigen Bedingungen gefundene Klimatisierungsverlauf ist dem an konventionellen Narkosegeräten überlegen.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0930-9225
    Keywords: Schlüsselwörter Systemic Inflammatory Response Syndrome (SIRS) ; Sepsis ; Routineabstrichuntersuchungen ; Antibiotikatherapie ; Key words Systemic inflammatory response syndrome (SIRS) ; sepsis ; routine swabs ; antibiotic treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Objective: Patients in a surgical intensive care unit (ICU) have a high incidence of nosocomial infections which often lead to septic shock and death. Since calculated antibiotic treatment is often difficult, it was recommended to obtain routine nose/throat swabs in order to have a better idea of the causative agent when a systemic inflammatory response occurs in a given patient.    Methods: In 1435 patients of our cardio-surgical ICU, routine nose/throat swabs were taken three times a week and tested for micro-organisms and resistance to antibiotics. Of these 86 patients developed clinical signs of systemic inflammation, and additional blood cultures were obtained. Antibiotic treatment was achieved to cover the microbes from the nose/throat swabs, or a calculated dosage was given to patients whose swabs had tested negative.    Results: Of the 86 patients with systemic inflammation, 29 had blood cultures positive for microbes. Of these 29 patients, 18 received a calculated antibiotic coverage based on their positive nose/throat cultures prior to the return of the blood cultures from the lab. However, in only 11 of the 18 patients were routine swabs and blood cultures positive with the same microbes. While positive routine swabs are quite specific for sepsis when there is a systemic inflammatory response, routine swabs are not a suitable screening tool due to their low sensitivity.    Conclusions: Routine nose/throat swabs led to earlier specific antibiotic treatment in only 22% of our patients with clinical signs of systemic inflammation. In addition, in almost 40% of the cases organisms detected in the routine swabs and blood cultures were not identical. As a result, we feel that routine swabs are only of limited value in instituting earlier, specific antibiotic treatment in septic patients.
    Notes: Zusammenfassung Patienten einer chirurgischen Intensivstation haben ein hohes Risiko einer nosokomialen Infektion, die nicht selten über ein septisches Krankheitsbild zum Tode führt. Da die Auswahl einer eng kalkulierten Antibiose oftmals schwierig ist, werden routinemäßige Rachenabstriche empfohlen, um so im Fall einer systemischen Infektion bereits einen Anhalt auf den möglichen Erreger zu haben und früher mit einer gezielten Antibiose beginnen zu können.    Methodik: Bei 1435 Patienten unserer herzchirurgischen Intensivstation erfolgten routinemäßig 3-mal wöchentlich Nasen-/Rachenabstriche, die auf Erreger und Resistenzen untersucht wurden. 86 dieser Patienten entwickelten eine systemische inflammatorische Reaktion, so dass zusätzlich die Entnahme von Blutkulturen erfolgte. Eine antibiotische Therapie wurde gezielt gegen die aus den Abstrichen bekannten Keime durchgeführt. Waren diese keimfrei, so erfolgte eine kalkulierte Antibiose.    Ergebnisse: Bei 29 der 86 Patienten konnte der Verdacht einer Sepsis durch Errregerisolation aus den Blutkulturen bestätigt werden. 18 dieser Patienten wurden aufgrund der positiven Abstrichbefunde bereits vor Bekanntwerden der Blutkulturergebnisse gezielt antibiotisch behandelt, wobei jedoch nur bei 11 Patienten das Keimspektrum der Abstriche mit dem der Blutkulturen übereinstimmte. Obwohl ein Keimnachweis in Routineabstrichen sehr spezifisch für das Vorliegen einer Sepsis bei systemischer Inflammation ist, eignet sich das Verfahren aufgrund seiner geringen Sensitivität nicht als Screeningmethode.    Schlussfolgerungen: Aufgrund routinermäßiger Abstriche konnte bei lediglich 22% aller Patienten mit Sepsisverdacht frühzeitiger eine vermeintlich gezielte Antibiotikatherapie begonnen werden. Da der für die Sepsis verantwortliche Keim zudem bei nahezu 40% der Patienten nicht mit dem aus den Abstrichen bekannten Keim übereinstimmte, muss der Stellenwert von Abstrichuntersuchungen als Routineverfahren angezweifelt werden.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 46 (1997), S. 201-206 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Atemgasklimatisierung ; Modell ; Narkosegerät ; PhysioFlex ; geschlossenes System ; Key words Climatisation of anaesthetic gases ; model ; Anaesthesia machine ; PhysioFlex ; Closed system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Closed-system anaesthesia provides the best prerequisites for optimal warming and humidification of anaesthetic gases. The PhysioFlex anaesthesia machine fascilitates quantitative closed-system anaesthesia. Furthermore, its design may improve the climatisation of the anaesthetic gases by revolving the system volume at 70 l/min, using a small soda-lime canister to allow optimal usage of the heat and moisture generated by CO2 absorption and by integrating all system components in thermally isolating housing. To determine the capacity of the PhysioFlex to climatise anaesthetic gases, we evaluated the heat and humidity profile at four characteristic places in the anaesthetic circuit under standardised conditions in a model. Materials and methods: In an air-conditioned room at 19–20° C ambient temperature, the PhysioFlex was operated with a fresh gas flow of less than 500 ml/min, similar to quantitative closed-system anaesthesia in adults. With a respiratory rate of 10/min and a tidal volume of 600 ml, a humidifier was ventilated, that delivered humidity-saturated gas at 33–34° C; 200 ml/min CO2 were added to the system at the humidifier to mimic the heat, moisture, and CO2 input of a patient into the anaesthetic circuit. A total of six series were performed, each starting with a cold and dry anaesthetic circuit. For 2 h the time-courses of temperature and humidity of the anaesthetic gases were measured at four distinct places: (1) in the soda-lime canister (M1); (2) at the outlet of the anaesthesia machine (M2); (3) at the inlet of the anaesthesia machine (M3); and (4) in the inspiratory limb close to the Y-piece (M4). Capacitive humidity sensors (VAISALA Type HMM 30 D without a protective cap) and very small thermocouples were used to measure relative humidity (rH) and temperature. The data were recorded at 5 min intervals. Due to the continuous gas stream in the system, the response time of the sensors, which is in the range of a few seconds, did not affect the accuracy of the measurement. With the temperature-dependent humidity content of 100% rH obtained from equation 1, absolute humidity was calculated. Results: The time courses of temperature and humidity at the different measuring points are depicted in Figs. 2 and 3, respectively. The steepest increase in temperature and humidity was observed at M1. Within 10 min 100% rH was achieved at all measuring points. Initially, there was a considerable temperature gradient between M1 and M2; this became gradually smaller, indicating system components with high heat capacities. There was only a small gradient between M2 and M4, indicating that there was only a small heat loss compared to the heat input. The recommended minimal climatisation of the anaesthetic gases of 20 mg H2O/l [20] was obtained within 10 min at M4. During the whole measuring period heat and humidity increased in the system, reaching a maximum at M4 after 120 min with average values of more than 28° C and 27 mg H2O/l, respectively. Conclusion: With the PhysioFlex anaesthesia machine employing closed-system conditions, minimal climatisation of anaesthetic gases was reached within 10 min. After a period of 120 min, the anaesthetic gases were nearly climatized to the extent recommended for long-term respirator therapy. To date, no comparable temperature and humidity level has been reported with conventional anaesthesia machines. The time course of the gradient between M1 and M2 may give an opportunity for further optimising the system in reducing heat loss after the soda-lime canister, the active heat and moisture source in the circuit. At about 32° C, the temperature in the soda-lime canister is 10–15° C less than in conventional anaesthesia machines. Thus, the use of thermally instable volatile anaesthetics in the PhysioFlex under closed-system conditions may be less critical than in conventional anaesthesia machines under minimal-flow conditions.
    Notes: Zusammenfassung Ziel: Das Wärme-Feuchte-Profil des Narkosegeräts PhysioFlex wurde am Modell beim Betrieb im geschlossenen System bestimmt. Methodik: An vier Meßstellen (Atemkalk, Geräteausgang, Geräteeingang, inspiratorisch vor dem Y-Stück) wurden der Temperatur- und Feuchteverlauf bei standardisierten Umgebungsbedingungen innerhalb der ersten 2 h nach Inbetriebnahme ermittelt. Ergebnisse: Nach 10 min herrschte an allen Meßorten Wasserdampfsättigung. Durch das konstruktionsbedingte Umwälzen des Systemvolumens mit 70 l/min kommt es zu einem schnellen Temperatur- und Feuchteausgleich im System. Die höchsten Werte (bis 32° C, bis 35 mg H2O/l Atemgas) werden über dem Atemkalk gemessen. Inspiratorisch werden im Mittel bereits nach 10 min mit 20 mg/l Feuchtewerte erreicht, die die minimalen Anforderungen an eine Narkosegasklimatisierung erfüllen. Nach 2 h werden mit annähernd 30 mg/l Feuchtewerte erreicht, die bislang an konventionellen Narkosegeräten nicht beschrieben werden konnten. Diskussion: Die im Vergleich zu konventionellen Narkosegeräten niedrigen Temperaturen über dem Atemkalk könnten den Einsatz thermolabiler Inhalationsanästhetika im PhysioFlex eher erlauben als in herkömmlichen Narkosegeräten unter „Minimal Flow”-Bedingungen. Der hohe Temperatur- und Feuchtegradient zwischen Atemkalk und Geräteausgang deutet auf einen Ansatzpunkt für eine weitere Optimierung hin.
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