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  • Analytical Chemistry and Spectroscopy  (5)
  • Fluorodeoxyglucose  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4 (1999)
    Springer
    European journal of nuclear medicine 26 (1999), S. 231-238 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Positron emission tomography ; Fluorodeoxyglucose ; Liver ; Metastasis ; Combretastatin A-4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract . There are major potential advantages in non-invasive measurement of preclinical tumour biology and therapeutic response in clinically relevant, internal body sites, notably the ability to follow outcome in individual animals rather than averaging results from groups. We have exploited positron emission tomography (PET) to determine the feasibility of detecting liver metastases in B6D2F1 mice using fluorine-18 fluorodeoxyglucose ([18F]FDG) both before and after treatment by the novel cytotoxic agent, combretastatin A-4. The normal distribution of [18F]FDG in the absence of disease was characterised, with the clear delineation of the brain, the heart and the urinary bladder in all studies. In untreated mice with liver metastases, a strong correlation (r 2 = 0.98) was found between the quantitative estimates of [18F]FDG uptake obtained by analysis of PET images, and those obtained from ex vivo assay of liver plus metastases excised immediately after imaging. In this first series, the effective limit of resolution was in livers containing a number of small metastases (range 8–14) with a single volume equivalent of approximately 200 mm3. PET image analysis was concordant with histological measurements in showing that single intraperitoneal doses of combretastatin A-4 resulted in an average 30% volume destruction of metastatic mass by 24 h following administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050382
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  • 2
    Electronic Resource
    Electronic Resource
    Field ionization mass spectrometry - I. NucleosidesThis paper is also Part IX in the series ‘Structural Biochemistry’. For Part VIII see g. R. Pettit and S. K. Gupta, J. Chem. Soc. (C), 1208 (1968). (1969)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1969), S. 521-531 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The field ionization mass spectra of a series of nucleosides are reported, and compared with spectra obtained by conventional electron-impact ionization. The latter are complex, with structurally significant molecular ion and sugar cleavage peaks often of low intensity or completely absent. In contrast, the field ion spectra are extremely simple, with all except guanosine (highest mass peak [M  -  18]) showing intense molecular ion peaks, and the characteristic sugar (S) and base (B + H) cleavage products as the only other important fragments.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210020506
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  • 3
    Electronic Resource
    Electronic Resource
    Field ionization mass spectrometry - III: Cardenolides (1971)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 5 (1971), S. 573-597 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron impact (EI) and field ionization (FI) mass spectra of some representative underivatized cardenolides have been studied together for the first time, with the objective of assessing the structural and in particular the sequence information afforded by this promising analytical method. Two series of cardenolides have been examined, each consisting of a mono-, di- and trisaccharide glycoside. The first was based on the aglycone digitoxigenin and comprised neriifolin, thevebioside and cerberoside; the second was based on the genin strophantidin and included cymarin, K-strophantin-β and K-strophantoside. Other cardiac glycosides investigated and discussed include digitoxin and helveticoside. Important and structurally diagnostic fragmentations have been uncovered, especially in FI mode. In addition, the EI and FI spectra of individual components of the cardenolides have been recorded, e.g. the genins digitoxigenin and strophantidin, and the mono-saccharides L-thevetose, D-cymarose and D-glucose.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210050509
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  • 4
    Electronic Resource
    Electronic Resource
    Field ionization mass spectrometry - II: Benzyloxycarbonyl and t-butyloxycarbonyl derivatives of some simple peptidesThis paper is also Part X in the Series [Structural Biochemistry.] For Part IX see ref. 23. (1970)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 3 (1970), S. 67-83 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A brief discussion is given of some factors that merit consideration in the analysis of peptides by mass spectrometry, with emphasis on sequence determination. The first systematic study of simple peptides by field ionization (FI) is described, and comparison made with the corresponding electron-impact (EI) ionization spectra, both at low resolution (approx. 1500). The substances examined were either benzyloxycarbonyl or t-butyloxycarbonyl derivatives of di-through pentapeptide methyl esters, containing the amino acids glycine, alanine, leucine, serine, threonine, proline and tyrosine. The incidences of sequence-characteristic cleavage peaks and rearrangement ion peaks were both slightly lower in the FI than the EI spectra, although the peak relative intensities generally were higher under FI conditions.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210030109
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  • 5
    Electronic Resource
    Electronic Resource
    High resolution mass spectrometry. Bufadienolides IPresented in part at the 19th Annual Conference on Mass Spectrometry and Allied Topics American Society for Mass Spectrometry, Atlanta, Georgia, May, 1971. (1972)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1972), S. 47-74 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Complete low resolution mass spectra and some high resolution data are presented and discussed for a series of naturally occurring 14β-hydroxy bufadienolides (toad venoms) and their derivatives, but excluding compounds with a 14β,15β-epoxy group. The bufadienolides employed were bufalin, bufotalin, gamabufotalin, telocinobufagin, arenobufagin, 3β-acetoxybufotalien, 3β-acetoxyhellebrigenin, 3β-acetoxybufalin, 3-ketobufalin, 14-anhydrobufalin, 3β-acetoxy-15-ketobufalin and 15α-hydroxybufalin. The relatively unsaturated 2-pyrone functionality at C-17β has been used as an integral label to distinguish (from elemental composition data) ions containing it, from those coming from other parts of the molecule that do not. Structural ‘ion types’ are proposed to interpret this spectral data, and the prognosis for structure elucidation of other bufadienolides by high resolution mass spectrometry appears good.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210060107
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  • 6
    Electronic Resource
    Electronic Resource
    High resolution mass spectrometry. Bufadienolides - II.Presented in part at the ASTM Committee E-14 and American Society for Mass Spectrometry, 19th Annual Conference on Mass Spectrometry and Allied Topics, Atlanta, Georgia, May 1971. (1972)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1972), S. 613-646 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Complete low resolution mass spectra and high resolution data for selected important peaks are presented and discussed for a series of naturally occurring 14β, 15β-epoxybufadienolides (toad poisons) and their derivatives. The compounds examined were resibufogenin, marinobufagin, cinobufagin, desacetylcinobufagin, cinobufotalin, desacetylcinobufotalin and resibufagin, and the derivatives were 11α-hydroxyresibufogenin, 3β-acetoxymarinobufagin, 3-ketocinobufagin, 3β-acetoxy-16β-desacetylcinobufagin, 3β-acetoxy-16-ketocinobufagin, resibufaginol, 14α-artebufogenin and 3β-suberyloxyresibufogenin methyl ester. The relatively unsaturated 2-pyrone group of C-17β has been used as an integral label to distinguish (from elemental composition data) ions containing it from those arising in other parts of the molecule that do not, and the spectra are interpreted in terms of structural ‘ion types’.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210060603
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