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  • Cell & Developmental Biology  (2)
  • Analytical Chemistry and Spectroscopy  (1)
  • Biotechnology.  (1)
  • 1
    Online Resource
    Online Resource
    Introduction to development engineering : a framework with applications from the field (2023)
    Cham : Springer
    Details Availability
    Keywords: Environmental engineering. ; Biotechnology. ; Bioremediation. ; Energy policy. ; Energy and state. ; Development economics. ; Economic development. ; Engineering design. ; Developmental psychology.
    Description / Table of Contents: Part I: A New Discipline: Development Engineering -- Chapter 1: The Role Of Technology In Development -- Chapter 2: The Development Engineering Framework: Innovate, Evaluate, Scale -- Chapter 3: Asking the Right Questions -- Part II: Water, Sanitation and Health -- Chapter 4: Advances In Water and Health Technologies -- Chapter 5: Case Study: Electrochemical Arsenic Remediation, India (Innovation) -- Chapter 6: Case Study: Information For Intermittent Water Supply, India (Evaluation) -- Chapter 7: Case Study: Mobile Phone Diagnostic Microscopy, Vietnam/Cameroon (Innovation, Scale) -- Part III: Governance -- Chapter 8: Technologies for Governance And Accountability -- Chapter 9: Case Study: Sensors For Aid Accountability, Rwanda (Evaluation, Scale) -- Chapter 10: Case Study: High Resolution Development Indicators, Afghanistan (Evaluation, Scale) -- Chapter 11: Case Study: Monitoring For Elections And Public Service Delivery, Kenya (Evaluation, Scale) -- Part IV: Energy and Resources -- Chapter 12: Advances in Energy & Environmental Technologies -- Chapter 13: Case Study: Economic Impacts Of Rural Electrification, Kenya (Evaluation, Scale) -- Chapter 14: Case Study: Cool Joule: Flexible Energy Loads, Nicaragua (Innovation, Evaluation) -- Chapter 15: Case Study: Cookstove Monitoring and Use In East Africa (Innovation, Evaluation) -- Part V: Information -- Chapter 16: Information and Communications Technology For Development -- Chapter 17: Case Study: Community Cellular Networks, Philippines (Innovation, Evaluation) -- Chapter 18: Case Study: ICT Solutions To Bring Telemedicine To Rural India (Innovation) -- Chapter 19: Case Study: Platforms For Development Data (ODK/Mezuri) (Innovation, Scale) -- PART VI: Markets (Incorporates Agriculture) -- Chapter 20: Technologies To Improve Market Performance -- Chapter 21: Case Study: Ag Market Information Platforms, India (Innovation, Evaluation, Scale) -- Chapter 22: Case Study: Agricultural Trading Platforms, Uganda (Innovation, Evaluation) -- Chapter 23: Case Study: Inventory And Supply Chain Tracking, Sri Lanka (Evaluation) -- PART VII: Human Capital (Incorporates Labor) -- Chapter 24: Increasing the Productivity of Human Capital -- Chapter 25: Case Study: Electronic Job Search Platforms, India (Evaluation, Scale) -- Chapter 26: Case Study: Customized E-Learning Innovations, India (Evaluation) -- Chapter 27: Case Study: TBD (Evaluation) -- PART VIII: Conclusion -- Chapter 28: Promising Directions in Development Engineering.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (xxi, 652 Seiten) , Illustrationen
    ISBN: 9783030860653
    URL: https://doi.org/10.1007/978-3-030-86065-3
    DOI: 10.1007/978-3-030-86065-3
    Language: English
    Note: Literaturangaben
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  • 2
    Electronic Resource
    Electronic Resource
    Role of the brachial somites in the development of the appendicular musculature in rat embryos (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 198 (1993), S. 86-96 
    Details
    ISSN: 1058-8388
    Keywords: Rat embryos ; Somites ; Limb bud ; Myogenic cells ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: DiI, a fluorescent lipophilic dye, was micro-injected into the brachial somites of 10.5 day rat embryos to determine whether these somites can contribute cells to the development of the fore-limb bud. The injected embryos were cultured and harvested at the 20-25-somite stage. The dye did not interfere with somitogenesis because, at the injection site, the DiI-labelled somites were able to differentiate into dermomyotome and sclerotome. We have analyzed cryo-sections of 20-21-somite stage embryos and were unable detect the presence of DiI-labelled cells in the fore-limb buds. However, at the 22-somite stage, a few DiI-positive cells were found in the proximal region of the limb bud. These labelled cells had migrated into the limb from the lateral border of the dermomyotome. From the 23-somite stage onwards, there were even more DiI-positive cells inside the limb. We have performed an additional set of experiments to confirm that the somitic cells do have the ability to invade and colonize the limb bud. This was achieved by first labelling newly formed somites isolated from the caudal region of 10.5 day embryos with DiI and then grafting them into corresponding regions in 8-11-somite stage hosts. The donor somites were not orientated when they were implanted into the host. However, this did not disrupt their ability to undergo normal somitogenesis. We have detected the presence of DiI-positive cells in the limb buds of approximately 71% of the 19-30-somite stage embryos that have been examined. This is similar to what we obtained for the injected embryos. Nevertheless, there is one slight difference and that is the stage the somitic cells begin their invasion of the limb. For the injected embryos, migration began at the 22-somite stage but in the transplanted embryos, it commenced as early as the 18-somite stage. We have also investigated the myogenic potential of the fore-limb bud at various stages of development to ascertain whether there is a correlation between the stage the somitic cells first appear in the limb bud and the stage the bud acquires the capacity to form skeletal muscles. This was realized by culturing fore-limb buds excised from 18-30-somite stage embryos conventionally and in the kidney capsules of adult rats. In both methods, bone and cartilage were present in all of the cultures whereas skeletal muscles were only present in cultured explants older than the 21-22-somite stage. The appearances of skeletal muscles in the cultures correlated exactly with the stage somitic cells began their invasion of limb (as seen in the DiI injected embryos). Based upon the indirect evidence that has been obtained, we tentatively propose that the brachial musculature of the rat embryo is derived from the somites while bone and cartilage are formed by the somatopleure of the limb. © 1993 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001980203
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of digits, ectoderm, and retinoic acid on chondrogenesis by mouse interdigital mesoderm in culture (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 201 (1994), S. 297-309 
    Details
    ISSN: 1058-8388
    Keywords: Cell death ; Interdigital chondrogenesis ; Type II procollagen mRNA ; Retinoic acid ; Hind limb bud ; Mouse embryo ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: We have cultured tissues isolated from the interdigital zones (IDZ) of the mouse footplate in the presence of the digits, ectoderm, and all-trans retionic acid. The objective was to understand how these various factors influence the developmental fate of the interdigital tissues. Neutral red staining showed that these tissues normally differentiate by dying between day 12.5-14.5. However, if they were isolated from the footplate between day 12.5-13.5 (when cell death is not overtly obvious in the IDZ) and maintained in organ culture, these tissues would develop into cartilage and soft connective tissues. In culture, chondrogenesis is initiated very rapidly in the interdigital explants as revealed by in situ hybridization with riboprobes specific for type IIA and IIB procollagen mRNAs. The ability of interdigital tissues to form cartilage is not attributed to factors present in the serum of the culture medium as this phenomenon is also observed in serumless cultures. We have found that if all-trans retinoic acid, at concentrations of 10-50 ng/ml culture medium, were added to the explants it could inhibit chondrogenesis and promote cell death. Moreover, in some of the cultures, a single digit was left attached to the interdigital tissue. This also dramatically reduced the incidence of chondrogenesis. We have tried to determine whether the digits and ectoderm can produce a diffusible factor that can prevent cartilage from developing by culturing day 12.5 interdigital tissues in ectoderm and digit conditioned media. The ectoderm conditioned medium had no effects on interdigital growth or chondrogenesis. In contrast, the size of interdigital explants cultured in the presence of digit conditioned medium was shown to be significantly smaller than the control. These explants also produced a smaller quantity of cartilage as revealed by Alcian blue binding assay. In sum, our results showed that the fate of the interdigital tissues are not fully determined until after day 13.5. These tissues have the potentials to form cartilage and soft connective tissues. We tentatively propose that these interdigital tissues do not normally realize their histogenetic potentials because of the antichondrogenic influence of the digits and retinoic acid. © 1994 Wiley-Liss, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1002010402
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  • 4
    Electronic Resource
    Electronic Resource
    An alternative to the 2D INADEQUATE experiment for detecting scalar coupling correlations between protonated and unprotonated carbons (1987)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 25 (1987), S. 176-178 
    Details
    ISSN: 0749-1581
    Keywords: INADEQUATE ; 2D NMR ; Carbon-carbon scalar coupling ; Polarization transfer ; Quaternary carbons ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The two-dimensional INEPT-INADEQUATE experiment gives correlation peaks for unprotonated carbons which show only half of the total available signal, because the enhanced 13C signal generated by polarization transfer is shared equally between protonated and unprotonated coupling partners by the double quantum filtration step. If precautions are taken to attenuate unwanted signals from protonated carbons, then the double quantum filtration step may be dispensed with, leaving a hydrogen-carbon-carbon relay sequence. This gives unidirectional coherence transfer, ensuring that the maximum possible signal is concentrated in a single cross-peak identifying the correlation between protonated and unprotonated carbons. By extending the basic HCC relay sequence to include an evolution period an enhanced 13C-13C COSY 2D spectrum may be produced, with the further advantage over the 2D INADEQUATE experiment that the range of 13C-13C coupling constants detectable is limited only by the available resolution.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260250217
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