ISSN:
1438-2199
Keywords:
Amino acids
;
N-2-Hydroxyacylcysteine
;
S-2-Hydroxyacylglutathione
;
Glyoxalase
;
Glutathione
;
Cysteine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary N-(R)-2-Hydroxyacyl-L-cysteine derivatives were conveniently synthesized by the reaction of the corresponding S-(R)-2-hydroxyacyl-glutathione with cysteine. The (R)2-hydroxyacyl group was transferred from the S-glutathionyl moiety to S-cysteinyl, forming the corresponding (R)S-2-hydroxyacylcysteine; this rearranged to the (R)N-hydroxyacylcysteine. These compounds have anti-proliferative activity associated with the inhibition ofde novo pyrimidine synthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00805839
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