ISSN:
1438-2199
Schlagwort(e):
Amino acids
;
N-2-Hydroxyacylcysteine
;
S-2-Hydroxyacylglutathione
;
Glyoxalase
;
Glutathione
;
Cysteine
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary N-(R)-2-Hydroxyacyl-L-cysteine derivatives were conveniently synthesized by the reaction of the corresponding S-(R)-2-hydroxyacyl-glutathione with cysteine. The (R)2-hydroxyacyl group was transferred from the S-glutathionyl moiety to S-cysteinyl, forming the corresponding (R)S-2-hydroxyacylcysteine; this rearranged to the (R)N-hydroxyacylcysteine. These compounds have anti-proliferative activity associated with the inhibition ofde novo pyrimidine synthesis.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00805839
Permalink