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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 659-662 
    ISSN: 1432-1076
    Keywords: Key words     Chronic hepatitis ; Hepatitis C virus ; Childhood ; malignancy ; Recombinant ; interferon-alpha
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/ m2 for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine aminotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 659-662 
    ISSN: 1432-1076
    Keywords: Chronic hepatitis ; Hepatitis C virus ; Childhood malignancy ; Recombinant interferon-alpha
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m2 for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine amnotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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  • 3
    Publication Date: 2020-11-19
    Description: We report on new stratigraphic, palaeomagnetic and anisotropy of magnetic susceptibility (AMS) results from the Amantea basin, located on-shore along the Tyrrhenian coast of the Calabrian Arc (Italy). The Miocene Amantea Basin formed on the top of a brittlely extended upper plate, separated from a blueschist lower plate by a low-angle top-to-the-west extensional detachment fault. The stratigraphic architecture of the basin is mainly controlled by the geometry of the detachment fault and is organized in several depositional sequences, separated by major unconformities. The first sequence (DS1) directly overlaps the basement units, and is constituted by Serravallian coarse-grained conglomerates and sandstones. The upper boundary of this sequence is a major angular unconformity locally marked by a thick palaeosol (type 1 sequence boundary). The second depositional sequence DS2 (middle Tortonian-early Messinian) is mainly formed by conglomerates, passing upwards to calcarenites, sandstones, claystones and diatomites. Finally, Messinian limestones and evaporites form the third depositional sequence (DS3). Our new biostratigraphic data on the Neogene deposits of the Amantea basin indicate a hiatus of 3 Ma separating sequences DS1 and DS2. The structural architecture of the basin is characterized by faulted homoclines, generally westward dipping, dissected by eastward dipping normal faults. Strike-slip faults are also present along the margins of the intrabasinal structural highs. Several episodes of syn-depositional tectonic activity are marked by well-exposed progressive unconformities, folds and capped normal faults. Three main stages of extensional tectonics affected the area during Neogene-Quaternary times: (1) Serravallian low-angle normal faulting; (2) middle Tortonian high-angle syn-sedimentary normal faulting; (3) Messinian-Quaternary high-angle normal faulting. Extensional tectonics controlled the exhumation of high-P/low-T metamorphic rocks and later the foundering of the Amantea basin, with a constant WNW-ESE stretching direction (present-day coordinates), defined by means of structural analyses and by AMS data. Palaeomagnetic analyses performed mainly on the claystone deposits of DSl show a post-Serravallian clockwise rotation of the Amantea basin. The data presented in this paper constrain better the overall timing, structure and kinematics of the early stages of extensional tectonics of the southern Tyrrhenian Sea. In particular, extensional basins in the southern Tyrrhenian Sea opened during Serravallian and evolved during late Miocene. These data confirm that, at that time, the Amantea basin represented the conjugate extensional margin of the Sardinian border, and that it later drifted south-eastward and rotated clockwise as a part of the Calabria-Peloritani terrane.
    Description: Published
    Description: 147-168
    Description: JCR Journal
    Description: reserved
    Keywords: paleomagnetism ; structural geology ; syn-sedimentary tectonics ; Amantea ; Calabria ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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