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  • 1
    Electronic Resource
    Electronic Resource
    Lack of topographical relationship between sites of aluminum deposition and senile plaques in the Alzheimer's disease brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 526-531 
    Details
    ISSN: 1432-0533
    Keywords: Key words Alzheimer's disease ; Senile plaques ; Tangles ; Aluminum ; Histochemical staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aluminum has been presumed to be involved in the pathogenesis or etiology of Alzheimer's disease. Histochemical demonstration of aluminum in autopsy brains from Alzheimer's disease victims by means of the solochrome azurine method in combination with the methenamine silver technique revealed aluminum-related staining in some neocortical and hippocampal senile plaques and tangles, as well as in the cytoplasm and/or the nuclei of some neurons, and in the cytoplasm of endothelial cells of blood capillaries and pericytes around larger blood vessels. In double-stained samples (first with methenamine silver and then with solochrome azurine) only some plaques displayed the presence of aluminum, while others did not show any sign of the presence of the trace metal. The specificity and sensitivity of solochrome azurine staining was checked in paper spot-test and test-tube experiments combined with flameless atomic absorption spectrophotometry. The results suggest that aluminum is present in brain samples from Alzheimer's disease victims, but the structural localization indicates that it is not primarily involved in the etiology of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294815
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Aluminum-induced neurofibrillary changes in axons and dendrites (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 190-197 
    Details
    ISSN: 1432-0533
    Keywords: Aluminum ; Neurofibrillary changes ; Axons ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the chronic effect of aluminum on the rabbit central nervous system (CNS) and documented the occurrence of axonal swellings (spheroids) and dendritic thickening in spinal cord neurons in addition to the accumulation of neurofibrillary material in the perikaryon. The axonal swellings always occurred at the first heminode, and the neurofilaments appeared disorganized, whereas in dendrites the neurofilaments generally retained their longitudinal arrangements. Although neurofibrillary tangles were present in cortical neurons, no axonal swellings were observed. Thickening of segments of apical dendrites proximal to the cell body affected by neurofibrillary changes was present. The axonal swellings resembled those observed in IDPN intoxication, and in amyotrophic lateral sclerosis, and may be useful as a model for studying these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685244
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Lack of topographical relationship between sites of aluminum deposition and senile plaques in the Alzheimer's disease brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 526-531 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Senile plaques ; Tangles ; Aluminum ; Histochemical staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aluminum has been presumed to be involved in the pathogenesis or etiology of Alzheimer's disease. Histochemical demonstration of aluminum in autopsy brains from Alzheimer's disease victims by means of the solochrome azurine method in combination with the methenamine silver technique revealed aluminum-related staining in some neocortical and hippocampal senile plaques and tangles, as well as in the cytoplasm and/or the nuclei of some neurons, and in the cytoplasm of endothelial cells of blood capillaries and pericytes around larger blood vessels. In double-stained samples (first with methenamine silver and then with solochrome azurine) only some plaques displayed the presence of aluminum, while others did not show any sign of the presence of the trace metal. The specificity and sensitivity of solochrome azurine staining was checked in paper spot-test and test-tube experiments combined with flameless atomic absorption spectrophotometry. The results suggest that aluminum is present in brain samples from Alzheimer's disease victims, but the structural localization indicates that it is not primarily involved in the etiology of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294815
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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