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  • 1
    Online Resource
    Online Resource
    SYSIMIT - Systemimmunologie und Image Mining in der translationalen Biomarkerforschung für die Transplantations- und Krebsmedizin : Schlussbericht : Laufzeit: 01.10.2016 bis 31.12.2018 = SYSIMIT - Mining the spatial patterns of adaptive immune responses to persisting tissue antigens to exploit the full predictive potential of protocol biopsies in transplantation and cancer research (2019)
    Hannover : Medizinische Hochschule Hannover
    Details Availability
    Keywords: Forschungsbericht ; Systemmedizin ; Pathologie ; Nierentransplantation ; Brustkrebs ; Biomarker
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (85 Seiten, 4,50 MB) , Illustrationen, Diagramme
    URL: https://doi.org/10.2314/KXP:1694302318
    DOI: 10.2314/KXP:1694302318
    Language: German
    Note: Förderkennzeichen BMBF 01ZX1608 A-C , Verbundnummer 01147833 , Teilprojekte 1/3 (FKZ 01ZX1608 B): Mathematische Modellierung der Genese ektopischer tertiärer lymphoider Follikel im Kontext von Nierentransplantationen zur Simulation der Effekte von B-Zell Therapien auf die humorale Seite von Abstoßungsreaktionen (TP1/M. Meyer-Hermann) - Ein mathematisches Modell der Interaktion zwischen T-Zellen und Epithelzellen in der lymphozytären Lobulitis im Grenzbereich zwischen erblichem Brustkrebs und angrenzendem Brustdrüsengewebe (TP3/H. Hatzikirou); Teilprojekt 2 (FKZ 01ZX1608 C): Bild- und Datenanalyse von räumlichen Immunzellmustern zur Entwicklung von neuen prognostischen Gewebemarkern (TP2/R. Schönmeyer); Teilprojekt 4 (FKZ 01ZX1608 A): Translation von prognostischen räumlichen Mustern entzündlicher Reaktionen auf Tumor-und Organspenderzellen in klinisch anwendbare Markerkombinationen (TP4/F. Feuerhake) , Laufzeit: 01.10.2016-31.12.2018 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Sprache der Zusammenfassung: Deutsch, Englisch
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  • 2
    Electronic Resource
    Electronic Resource
    Increased excretion of harman by alcoholics depends on events of their life history and the state of the liver (1985)
    Springer
    Psychopharmacology 87 (1985), S. 64-68 
    Details
    ISSN: 1432-2072
    Keywords: Alcoholics ; Harman ; Trace amines ; β-carbolines ; Liver histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Based on the hypothesis of a relationship between the concentration of trace amines like tetrahydroisoquinolines (TIQ's) and β-carbolines (BC's) in the brain and an increased voluntary ingestion of ethanol, the concentrations of ethanol, acetaldehyde and harman (a β-carboline) were examined in a group of 20 alcoholics. The patients excreted a higher amount of harman into the urine than non-alcoholics on the day of admission (harman-1) as well as at the end of the detoxication period, 14 days later (harman-14). Certain factors were related to the increased excretion of harman by alcoholics: The younger the patient when he/she consumed ethanol for the first time, the higher the concentration of acetaldehyde in the blood and the amount of harman (harman-14) excreted in the urine. Furthermore, the younger the patient when he/she was intoxicated with ethanol for the first time the higher the amount of harman (harman-14) in the urine. Patients with first grade relatives who were alcoholics excreted more harman (harman-14) than those without such relatives. The following variables were not related to harman-14: The average amount of ethanol consumed daily during the 6 months prior to admission, the presence of signs of intoxication and symptoms of withdrawal at admission to hospital, and the consumption of other psychotropic substances. A negative correlation was found between the state of the liver, as assessed by liver histology and γ-glutamate transferase (γ-GT) levels, and the concentration of harman in the urine. Thus, some events in the patient's history as well as the state of the liver are important for the increased excretion of harman into urine of alcoholics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431780
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A method for the preparation of large intact sheets of intestinal mucosa: Application to the study of mouse aggregation chimeras (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 210 (1984), S. 407-411 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A technique for the preparation of entire intestinal mucosal sheets is described that renders the population of crypts accessible for two-dimensional study. We have applied the technique to demonstrate the mosaic crypt populations in the intestinal epithelium of mouse aggregation chimeras, using the lectin Dolichos biflorus agglutinin (DBA) as a strain-specific histochemical marker.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092100216
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  • 4
    Electronic Resource
    Electronic Resource
    From patterns to clones in chimaeric tissues (1987)
    New York, NY : Wiley-Blackwell
    BioEssays 6 (1987), S. 104-108 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: This essay summarizes recent advances made in the analysis of mosaic patches in chimaeric epithelia of the mouse. The conclusions drawn from the observed patterns are relevant to the behaviour of expanding cell populations during tissue growth and homeostasis. References are made to clonal analysis of Drosophila.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950060303
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  • 5
    Electronic Resource
    Electronic Resource
    Problems and paradigms: On the clonal origin of tumours - lessons from studies of intestinal epithelium (1990)
    New York, NY : Wiley-Blackwell
    BioEssays 12 (1990), S. 37-40 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Clonal studies of adult chimaeric mouse epithelium have demonstrated the monoclonal composition of crypts of Lieberkühn(1). In neonatal life, however, polyclonal crypts have been found, indicating that crypts are of polyclonal origin(2). We here relate these findings to studies of mosaic tissues which have addressed the question whether solid tumours are of monoclonal or polyclonal origin (ref. 3 for review, 4). The issues has so far remained unresolved because the expected frequencies of polyclonal tumours, given polyclonal origins, have not previously been estimated. A general approach for the calculation of such expected values is suggested. The consistent reports of tumours with polyclonal components suggest that autocrine or paracrine mechanisms play an important role during tumorigenesis.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950120109
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