ISSN:
1435-1803
Keywords:
Adrenergic changes cardiomyopathy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Natural history of myocardial dysfunction due to chronic contractile deficit consists of physiological and pathophysiological adaptations culminating in congestive heart failure. Among the mechanisms considered is the combination of compensatory as well as the harmful overcompensatory role of the adrenergic system during the genesis of a congestive heart failure “spiral” due to the chronic treatment with adriamycin. Refractoriness of this spiral to various inotropic agents may involve reduced sympathetic support of the myocardium, structural loss of contractile elements and abnormalities of the Ca2+ metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00788661
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