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  • Adrenergic changes cardiomyopathy  (1)
  • NADPH  (1)
Document type
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Effect of nifedipine administration on the functional capacity of neutrophils (1993)
    Springer
    Molecular and cellular biochemistry 120 (1993), S. 81-85 
    Details
    ISSN: 1573-4919
    Keywords: neutrophils ; nifedipine ; superoxide ; chemotaxis ; phagocytosis ; NADPH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Administration of nifedipine to mice over a period of six months caused a significant (p〈0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00925987
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Significance of adaptation mechanisms in adriamycin induced congestive heart failure (1992)
    Springer
    Basic research in cardiology 87 (1992), S. 512-518 
    Details
    ISSN: 1435-1803
    Keywords: Adrenergic changes cardiomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Natural history of myocardial dysfunction due to chronic contractile deficit consists of physiological and pathophysiological adaptations culminating in congestive heart failure. Among the mechanisms considered is the combination of compensatory as well as the harmful overcompensatory role of the adrenergic system during the genesis of a congestive heart failure “spiral” due to the chronic treatment with adriamycin. Refractoriness of this spiral to various inotropic agents may involve reduced sympathetic support of the myocardium, structural loss of contractile elements and abnormalities of the Ca2+ metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788661
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
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