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  • Adrenal medulla and cortex  (1)
  • Climbing fibers  (1)
  • 1
    Electronic Resource
    Electronic Resource
    On the mechanism of the decrease in cerebellar cyclic GMP content elicited by opiate receptor agonists (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 117-121 
    Details
    ISSN: 1432-1912
    Keywords: Cerebellum ; cGMP ; Morphine ; Mossy fibers ; Climbing fibers ; Striatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphine, dextromoramide (4 μmol/kg i.p.) and vimonol R2 (17 μmol/kg i.p.) in analgesic doses (28 to 112 μmol/kg i.p.) decreased 3′,5′-cyclic guanosine monophosphate (cGMP) in rat cerebellar cortex; morphine also decreased the cGMP content in deep cerebellar nuclei. Intrastriatal but not intracerebellar injections of morphine (20 μg) decreased cerebellar cGMP content. Naltrexone, an opiate receptor antagonist, but not apomorphine, a dopaminergic receptor agonist, blocked the effect of morphine on cerebellar cGMP. Pretreatment with 3-acetylpyridine (3-AP) which destroys the climbing fibers, failed to antagonize the effect of morphine on cerebellar cGMP. These results suggest that activation of opiate receptors in striatum decreases cerebellar cGMP content presumably by reducing activity in the mossy fiber excitatory input to cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508462
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Association between the increase of cAMP content and the trans-synaptic induction of tyrosine hydroxylase in rat adrenal medulla (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 295 (1976), S. 135-140 
    Details
    ISSN: 1432-1912
    Keywords: Tyrosine hydroxylase ; Reserpine ; cAMP ; Protein kinase ; Dexamethasone ; Adrenal medulla and cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary When dexamethasone 0.25 or 2.5 μmole/kg i.p. was injected 2 h before reserpine (16 μmol/kg i.p.) the time course of the increase in cAMP content of rat adrenal medulla was changed. Reserpine alone caused a monophasic increase lasting between 1–2 h; reserpine after dexamethasone caused a biphasic increase: the immediate response, lasting between 15 and 30 min, was followed by a secondary increase beginning 2–3 h after reserpine and lasting for several hours. The overall increase in cAMP content elicited by reserpine during the 8 h following injection remained unchanged or was even increased, depending on the dose of dexamethasone. Pretreatment with dexamethasone, which delayed the increase in cAMP, also delayed the activation and translocation of protein kinase and the induction of tyrosine hydroxylase caused by reserpine in adrenal medulla. The action of reserpine on the cAMP content of adrenal medulla required an intact innervation and did not appear to be related to increased secretion of ACTH from pituitary. In denervated adrenals reserpine failed to increase the cAMP content of the medulla but not that of the cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499445
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
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