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  • 1
    Electronic Resource
    Electronic Resource
    Involvement of 3′,5′-cyclic adenosine monophosphate in the increase of tyrosine hydroxylase activity elicited by cold exposure (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 278 (1973), S. 195-206 
    Details
    ISSN: 1432-1912
    Keywords: cAMP ; Tyrosine Hydroxylase ; Adrenal Medulla ; Cold Exposure ; Catecholamine Turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the relationship between changes of 3′,5′-cyclic adenosine monophosphate (cAMP) and tyrosine hydroxylase (TH) activity in adrenal medulla of rats exposed to cold stress. Exposure of rats to 4° C produced a ten-fold increase of the cAMP content of adrenal medulla in about 30 min. This increase persisted for about one hour; the levels of cAMP returned to control value within 120 min in spite of the continued exposure to 4° C. In rats with monolaterally denervated (splanchnicotomized) adrenal, the exposure to 4° C produced only insignificant changes of cAMP concentration. During the exposure to 4° C we also observed an increase (about two times) of catecholamine turnover rate as measured by 3H-dopamine efflux from adrenal glands. This increased efflux persisted for 6 h of exposure to cold suggesting that the efflux of 3H-dopamine can increase without a simultaneous increase of cAMP concentrations. Exposure of rats to 4° C for two hour also increases (about two times) the TH activity as measured 24 h later. Exposure of the animals to 4° C for a time period longer than two hour (4 or 24 h) failed to produce further increases of TH activity. These results support the concept that the increase of cAMP concentrations in adrenal medulla may play a central role in initiating the chain of biochemical events modulating the synthesis of TH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500650
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Association between increase in cyclic AMP and subsequent induction of tyrosine hydroxylase in rat adrenal medulla (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 217-221 
    Details
    ISSN: 1432-1912
    Keywords: Cyclic AMP ; Cyclic GMP ; Swimming Stress ; Hypothermia ; Tyrosine Hydroxylase ; Adrenal Medulla
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After male rats (100 g body weight) have completed 7 min of swimming at 15°C, their rectal temperature is decreased by 15°C. As expected, the increase of cAMP and the decrease of cGMP concentrations in adrenal medulla are delayed by the time period necessary for the body temperature to return to normal. Thus, taking into consideration the delaying effect of hypothermia, the swimming stress experiments are in agreement with the view that the enhancement of cyclic AMP/cGMP concentration ratios may function as the second messengers for the induction of tyrosine hydroxylase in adrenal medulla.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499036
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    Paper (German National Licenses)
    Fulltext
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