ISSN:
1432-0428
Keywords:
Activity of pentulokinases
;
sorbitol dehydrogenase and gluconokinase-organs of guinea pigs of normal and diabetic rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In guinea pig tissues the activities of the enzymes D-gluconokinase, sorbitol dehydrogenase, D-ribulo- and D-xylulokinase were measured. D-ribulose and D-xylulose were prepared by isomerisation of D-ribose and D-xylose in pyridine and separated by preparative paper chromatography. The activity patterns of the pentulokinases were identical in all tested organs. The highest activities of these two enzymes were found in adipose tissue, when referred to soluble cell protein, and was higher than the activity in liver and kidney. The high enzyme activities of the pentulokinases in adipose tissue may explain the antilipolytic effect of these pentitols and pentoses in diabetes. The activities of sorbitol dehydrogenase and gluconokinase showed a similar activity pattern in all tested organs of the guinea pig. The highest activities were found in liver and kidney and the lowest in the adipose tissue. The direct metabolism of gluconate in adipose tissue seems impossible. The activity of the pentulokinases are diminished in the tissues of the diabetic rat.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01225997
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