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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 357-360 
    ISSN: 1432-1335
    Keywords: Key words Colorectal neoplasms ; Apoptosis ; Chemosensitivity ; p53 gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose : The p53 gene is considered one of the most important in the control of apoptosis, and its mutations have a close relationship with chemosensitivity. The aim of this work was to investigate the role of p53 in the apoptosis of colorectal cancer cells in vitro, induced by 5-fluorouracil (5-FU) and hydroxy-camptothecin (HCPT). Methods : A total of 39 colorectal cancer samples from patients were treated in vitro with 5-FU (10 μg/ml), 5-FU (10 μg/ml) + leucovorin (5 μg/ml), HCPT (0.1 μg/ml) and HCPT (0.1 μg/ml) + Salvia mitorrhiza (6 μl), using an in situ terminal deoxynucleotidyltransferase assay to detect chemosensitivity. p53 gene mutations from tumor DNA were detected, after amplification by the polymerase chain reaction of exons 5–8, by non-radioactive single-strand conformation polymorphism. Results : p53 gene mutations were observed in 43.6% (17/39) of colorectal carcinomas, when the terminal deoxynucleotidyltransferase assay was used to detect the tumor apoptotic rate. Cells with mutated p53 had lower chemosensitivity than those without (p 〈 0.01). Conclusion : Routine assessment of p53 status may be helpful in selecting patients with the wild-type p53 gene, who have a predictably better response to chemotherapy.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2021-05-19
    Description: Taiwan Island is at the joint of Eurasian Continent and Pacific Plate, under threatening of typhoons and northeasterly strong winds. Consequently, enormous human lives and properties are lost every year. It is necessary to develop a coastal sea-state monitoring system. This paper introduces the coastal sea-state monitoring system (CSMS) along Taiwan coast. The COMC (Coastal Ocean Monitoring Center in National Cheng Kung University) built the Taiwan coastal sea-state monitoring system, which is modern and self-sufficient, consisting of data buoy, pile station, tide station, coastal weather station, and radar monitoring station. To assure the data quality, Data Quality Check Procedure (DQCP) and Standard Operation Procedure (SOP) were developed by the COMC. In further data analysis and data implementation of the observation, this paper also introduces some new methods that make the data with much more promising uses. These methods include empirical mode decomposition (EMD) used for the analysis of storm surge water level, wavelet transform used for the analysis of wave characteristics from nearshore X-band radar images, and data assimilation technique applied in wave nowcast operation. The coastal sea-state monitoring system has a great potential in providing ocean information to serve the society.
    Description: Published
    Keywords: Mooring buoys ; Acoustic waves ; Monitoring
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 3
    Publication Date: 2016-04-17
    Description: Author(s): Yan-Feng Lv, Wen-Lin Wang, Hao Ding, Yang Wang, Ying Ding, Ruidan Zhong, John Schneeloch, G. D. Gu, Lili Wang, Ke He, Shuai-Hua Ji, Lin Zhao, Xing-Jiang Zhou, Can-Li Song, Xu-Cun Ma, and Qi-Kun Xue By means of low-temperature scanning tunneling microscopy, we report on the electronic structures of the BiO and SrO planes of the Bi 2 Sr 2 CuO 6 + δ (Bi-2201) superconductor prepared by argon-ion bombardment and annealing. Depending on post annealing conditions, the BiO planes exhibit either a pseudogap … [Phys. Rev. B 93, 140504(R)] Published Fri Apr 15, 2016
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 4
    Publication Date: 2018-01-23
    Description: Author(s): Yu-Ping Wu, Xing-Can Yao, Xiang-Pei Liu, Xiao-Qiong Wang, Yu-Xuan Wang, Hao-Ze Chen, Youjin Deng, Yu-Ao Chen, and Jian-Wei Pan Recent experimental realizations of superfluid mixtures of Bose and Fermi quantum gases provide a unique platform for exploring diverse superfluid phenomena. We study dipole oscillations of a double superfluid in a cigar-shaped optical dipole trap, consisting of K 41 and Li 6 atoms with a large mass i... [Phys. Rev. B 97, 020506(R)] Published Mon Jan 22, 2018
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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