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  • Abies lasiocarpa, cover; Achillea millefolium, cover; Alnus alnobetula, cover; Alnus sp., cover; Anemone parviflora, cover; Apiaceae, cover; Arctagrostis latifolia, cover; Arctostaphylos uva-ursi, cover; Arctous rubra, cover; AWI_Envi; AWI Arctic Land Expedition; Betula glandulosa, cover; Betula occidentalis, cover; Bistorta plumosa, cover; Bistorta vivipara, cover; boreal forest; British Columbia, Canada; CA-Land_2022_NWCanada; Carex scirpoidea, cover; Carex sp., cover; Chamaenerion angustifolium, cover; Cornus canadensis, cover; Cyperaceae, cover; Dasiphora fruticosa, cover; DATE/TIME; Deadwood, cover; Diphasiastrum complanatum, cover; Drosera rotundifolia, cover; Dryas integrifolia, cover; ELEVATION; Empetrum nigrum, cover; EN22002; EN22003; EN22004; EN22005; EN22006; EN22007; EN22008; EN22009; EN22010; EN22011; EN22012; EN22018; EN22019; EN22020; EN22021; EN22032; EN22033; EN22034; EN22037; EN22039; EN22046; EN22047; EN22049; EN22052; EN22055; EN22058; EN22060; EN22062; EN22063; EN22065; EN22069; EN22071; Equisetum arvense, cover; Equisetum sp., cover; Equisetum sylvaticum, cover; Eriophorum sp., cover; Eriophorum vaginatum, cover; Event label; Fabaceae, cover; Festuca altaica, cover; Field observation; Forest Change Northwest Canada; Fragaria virginiana, cover; Galium sp., cover; Geocaulon lividum, cover; Geraniaceae, cover; ground vegetation; Hedysarum alpinum, cover; Indeterminata, cover; Juniperus communis, cover; Juniperus horizontalis, cover; Kalmia procumbens, cover; LATITUDE; Ledum groenlandicum, cover; Ledum palustre, cover; Ledum sp., cover; Linnaea borealis, cover; LONGITUDE; Lupinus arcticus, cover; Mertensia paniculata, cover; Northwest Territories, Canada; Orthilia secunda, cover; Pedicularis labradorica, cover; Pedicularis sp., cover; Permafrost; Petasites frigidus, cover; Petasites sp., cover; Picea glauca, cover; Picea mariana, cover; Platanthera aquilonis, cover; Platanthera obtusata, cover; Poaceae, cover; Polar Terrestrial Environmental Systems @ AWI; Pyrola asarifolia, cover; Pyrola chlorantha, cover; Pyrola grandiflora, cover; Pyrola minor, cover; Pyrola sp., cover; Ranunculaceae, cover; Rhododendron lapponicum, cover; Rhododendron sp., cover; Ribes sp., cover; Rosa acicularis, cover; Rubus chamaemorus, cover; Rumex arcticus, cover; Salix pulchra, cover; Salix reticulata, cover; Salix sp., cover; Saussurea angustifolia, cover; Saxifragaceae, cover; Senecio lugens, cover; Shepherdia canadensis, cover; Sorbus aucuparia, cover; Spinulum annotinum, cover; Spiraea stevenii, cover; Tofieldia pusilla, cover; Vaccinium microcarpum, cover; Vaccinium uliginosum, cover; Vaccinium vitis-idaea, cover; Vegetation; vegetation survey; Vegetation survey; VEGSUR; Viburnum edule, cover; Visual estimation in exact nadir according to Li et al. 2023; Yukon, Canada  (1)
  • L-OddC  (1)
Document type
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Effects of Ape1 Overexpression on Cellular Resistance to DNA-Damaging and Anticancer Agents (1999)
    Springer
    Somatic cell and molecular genetics 25 (1999), S. 253-262 
    Details
    ISSN: 1572-9931
    Keywords: Ape1 ; base excision repair ; cellular resistance ; L-OddC ; antimetabolite/nucleoside analog ; antiviral/anticancer agent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In vitro biochemical studies indicate that Ape1 is the major mammalian enzyme responsible for repairing abasic lesions in DNA and a significant factor in the processing of specific 3′-replication-blocking termini. Toward addressing the role of Ape1 in cellular resistance to specific DNA-damaging and anticancer agents, we constructed a chinese hamster ovary (CHO) cell line, AA8-Ape1, that exhibits a 7-fold higher Ape1-dependent nuclease activity; this overexpression is abolished upon exposure to tetracycline (Tc). In comparison to the AA8 parental control, our data indicates that Ape1 activity is not rate-limiting for the repair of cytotoxic damages induced by the alkylating agent methyl methanesulfonate (MMS), the oxidizing agent hydrogen peroxide (H2O2), or ionizing radiation (IR). AA8-Ape1 cells did exhibit increased resistance to bleomycin following a chronic 3-day exposure, but not to more acute challenges of 1 h. Most notably, the AA8-Ape1 line displayed ∼1.7-fold elevated resistance to the replication-blocking nucleoside analog dioxolane cytidine (L-OddC); this improved resistance was abrogated by the addition of Tc to the medium. These studies demonstrate that Ape1 is not rate-limiting in the repair of MMS- or H2O2-induced DNA damage, that Ape1 may dictate the sensitivity of bleomycin, depending on dosing scheme, and for the first time, that Ape1 can influence cellular resistance to the anticancer/antiviral antimetabolite L-OddC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019979613989
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    facet.materialart.
    Unknown
    Aggregated herbaceous layer projective vegetation cover at 32 sites in Northwestern Canada, in Summer 2022 (CA-Land_2022_NWCanada) (2023)
    PANGAEA
    Details
    Publication Date: 2024-02-01
    Description: Vegetation surveys were carried out in Northwest Territories, Yukon and British Columbia in Canada. The study area is within the boreal forest biome and is partially underlain by permafrost soils. The aim was to record the projective ground vegetation in different boreal forest types studied during the CA-Land_2022_NWCanada field campaign in July and August 2022. The ground vegetation projective cover in percent was assessed within a circular forest plot of 15m radius. Depending on the heterogeneity of the forest plot, multiple vegetation types (VA, VB, or VC) were surveyed separately. The assignment of a vegetation type is always unique to a site. Up to four quadrats of 2x2 m were surveyed per vegetation type and projective cover in percent recorded separately for herbaceous and moss layers. All vegetation smaller than 40cm was recorded. Additionally, ground vegetation projective cover was surveyed in 4 rings of 50 cm width around the center of the circular forest plot. Average projective cover per plot was calculated by using an average weighted by vegetation types for each site. The ring survey data was not included in the plot average. In total 32 forest plots were investigated. All data were collected by scientists from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) Germany, and the University of Potsdam Germany.
    Keywords: Abies lasiocarpa, cover; Achillea millefolium, cover; Alnus alnobetula, cover; Alnus sp., cover; Anemone parviflora, cover; Apiaceae, cover; Arctagrostis latifolia, cover; Arctostaphylos uva-ursi, cover; Arctous rubra, cover; AWI_Envi; AWI Arctic Land Expedition; Betula glandulosa, cover; Betula occidentalis, cover; Bistorta plumosa, cover; Bistorta vivipara, cover; boreal forest; British Columbia, Canada; CA-Land_2022_NWCanada; Carex scirpoidea, cover; Carex sp., cover; Chamaenerion angustifolium, cover; Cornus canadensis, cover; Cyperaceae, cover; Dasiphora fruticosa, cover; DATE/TIME; Deadwood, cover; Diphasiastrum complanatum, cover; Drosera rotundifolia, cover; Dryas integrifolia, cover; ELEVATION; Empetrum nigrum, cover; EN22002; EN22003; EN22004; EN22005; EN22006; EN22007; EN22008; EN22009; EN22010; EN22011; EN22012; EN22018; EN22019; EN22020; EN22021; EN22032; EN22033; EN22034; EN22037; EN22039; EN22046; EN22047; EN22049; EN22052; EN22055; EN22058; EN22060; EN22062; EN22063; EN22065; EN22069; EN22071; Equisetum arvense, cover; Equisetum sp., cover; Equisetum sylvaticum, cover; Eriophorum sp., cover; Eriophorum vaginatum, cover; Event label; Fabaceae, cover; Festuca altaica, cover; Field observation; Forest Change Northwest Canada; Fragaria virginiana, cover; Galium sp., cover; Geocaulon lividum, cover; Geraniaceae, cover; ground vegetation; Hedysarum alpinum, cover; Indeterminata, cover; Juniperus communis, cover; Juniperus horizontalis, cover; Kalmia procumbens, cover; LATITUDE; Ledum groenlandicum, cover; Ledum palustre, cover; Ledum sp., cover; Linnaea borealis, cover; LONGITUDE; Lupinus arcticus, cover; Mertensia paniculata, cover; Northwest Territories, Canada; Orthilia secunda, cover; Pedicularis labradorica, cover; Pedicularis sp., cover; Permafrost; Petasites frigidus, cover; Petasites sp., cover; Picea glauca, cover; Picea mariana, cover; Platanthera aquilonis, cover; Platanthera obtusata, cover; Poaceae, cover; Polar Terrestrial Environmental Systems @ AWI; Pyrola asarifolia, cover; Pyrola chlorantha, cover; Pyrola grandiflora, cover; Pyrola minor, cover; Pyrola sp., cover; Ranunculaceae, cover; Rhododendron lapponicum, cover; Rhododendron sp., cover; Ribes sp., cover; Rosa acicularis, cover; Rubus chamaemorus, cover; Rumex arcticus, cover; Salix pulchra, cover; Salix reticulata, cover; Salix sp., cover; Saussurea angustifolia, cover; Saxifragaceae, cover; Senecio lugens, cover; Shepherdia canadensis, cover; Sorbus aucuparia, cover; Spinulum annotinum, cover; Spiraea stevenii, cover; Tofieldia pusilla, cover; Vaccinium microcarpum, cover; Vaccinium uliginosum, cover; Vaccinium vitis-idaea, cover; Vegetation; vegetation survey; Vegetation survey; VEGSUR; Viburnum edule, cover; Visual estimation in exact nadir according to Li et al. 2023; Yukon, Canada
    Type: Dataset
    Format: text/tab-separated-values, 2656 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
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