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  • 1
    Electronic Resource
    Electronic Resource
    Discovery of atrial natriuretic factor in the brain: Its characterization and cardiovascular implication (1989)
    Springer
    Cellular and molecular neurobiology 9 (1989), S. 75-85 
    Details
    ISSN: 1573-6830
    Keywords: atrial natriuretic factor (ANF) in brain ; radioimmunoassay ; immunohistochemistry ; ANF mRNA ; ANF molecular forms ; antidipsogenic action ; antihypertensive action ; suppression of vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. We have devised a radioimmunoassay for atrial natriueretic factor (ANF). Its application to rat brain extract led to the discovery of ANF in the brain. In addition to the hypothalamus and the pontine medullary region, it was widely distributed. 2. ANF in the brain is stored in a low molecular weight form, in contrast to pro-ANF in the atria. Thus, the processing of pro-ANF in the bran neuronal cells is different from that in the atria. 3. ANF was found in the anterior and posterior lobes of the pituitary, the peripheral ganglia, adrenergic neurons, and the adrenal medulla. 4. Brain ANF suppressed stimulated dipsogenesis, basal and stimulated vasopressin release, and angiotensin II-stimulated pressor effects. 5. ANF in the peripheral neuronal system inhibits catecholamine synthesis and release. Thus, central ANF functions to reduce the peripheral fluid volume and vascular tone in concert with the peripheral ANF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711444
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Modification of developmental instability and fitness: Malathion-resistance in the Australian sheep blowfly,Lucilia cuprina (1993)
    Springer
    Genetica 89 (1993), S. 67-76 
    Details
    ISSN: 1573-6857
    Keywords: Lucilia cuprina ; malathion-resistance ; fluctuating asymmetry ; fitness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The evolution of resistance to malathion byLucilia cuprina initially results in an increase in fluctuating asymmetry. Resistant flies are at a selective disadvantage, relative to susceptibles, in the absence of the insecticide. A fitness/asymmetry modifier of diazinon-resistant phenotypes ameliorates these effects resulting in malathion-resistant phenotypes of relative fitness and asymmetry similar to susceptibles. For the nine genotypic combinations of the modifier and malathion-resistance alleles, developmental time increases linearly with increasing asymmetry. Percentage egg hatch decreases linearly with increasing asymmetry. The initially disruptive effect of the malathion-resistant allele was partially dominant, the effect of the modifier dominant. The results are discussed in terms of developmental perturbation, asymmetry estimation and relative fitness to consider whether it is adequate to use changes in fluctuating asymmetry alone as measures of developmental instability. It is suggested that in some circumstances antisymmetry may indicate developmental instability and that the diazinon/malathion-resistance systems inL. cuprina may allow the relative importance of genetical and/or environmental developmental perturbations to be ascertained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02424506
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Measuring fitness and intergenic interactions: The evolution of resistance to diazinon inLucilia cuprina (1993)
    Springer
    Genetica 90 (1993), S. 227-237 
    Details
    ISSN: 1573-6857
    Keywords: Lucilia cuprina ; diazinon resistance ; fitness ; asymmetry ; frequency-dependent selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Resistance at the diazinon-resistance locus (Rop-1) is recessive with respect to fitness. Selection initially occurs at concentrations lower than those required to controlLucilia cuprina. The presence of theRop-1 allele initially disrupted development so that in the absence of diazinon, carriers were at a relative selective disadvantage. Continued use of the chemical, subsequent to resistance evolving, selected a modifier to ameliorate this effect. Modified resistant phenotypes show similar developmental stability and relative fitness to susceptible individuals. Frequency-dependent interactions are observed between resistant and susceptible phenotypes of theRop-1 locus. The interactions are determined by the concentration of diazinon and range from competitive to facilitative. The results are discussed in the context of the contribution insecticide resistance systems can make to the study of general evolutionary phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01435042
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    Paper (German National Licenses)
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