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  • 99mTc  (1)
  • Dreidimensionales Modell  (1)
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  • 1
    Online Resource
    Online Resource
    Matrix Discrete Element Analysis of Geological and Geotechnical Engineering (2021)
    Singapore : Springer Singapore | Singapore : Imprint: Springer
    Details Availability
    Keywords: Geotechnical engineering. ; Engineering geology. ; Engineering—Geology. ; Foundations. ; Hydraulics. ; Computer-aided engineering. ; Angewandte Mathematik ; Computersimulation ; Diskrete-Elemente-Methode ; Modellierung ; Bodenmechanik ; Rutschung ; Ingenieurgeologie ; Geomechanik ; Dreidimensionales Modell
    Description / Table of Contents: Chapter 1 Principles and Implementation of DEM -- Chapter 2 The Basic Structure of MatDEM -- Chapter 3 Geometric Modeling and Material Setup -- Chapter 4 Load Settings and Numerical Calculations -- Chapter 5 Postprocessing and System Functions -- Chapter 6 Basic Application of Geotechnical Engineering -- Chapter 7 Rock-Soil Body Discrete Element Test -- Chapter 8 Modeling of Complex 3D Models -- Chapter 9 Numerical Simulations of Dynamic Action -- Chapter 10 Multi-field Coupled Numerical Simulation -- Appendix Properties, Functions and Frequently Asked Questions.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource(XXIII, 294 p. 349 illus., 117 illus. in color.)
    Edition: 1st ed. 2021.
    ISBN: 9789813345249
    Series Statement: Springer eBook Collection
    URL: https://doi.org/10.1007/978-981-33-4524-9
    DOI: 10.1007/978-981-33-4524-9
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Noninvasive Assessment of Tumor Hypoxia with 99mTc Labeled Metronidazole (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 743-750 
    Details
    ISSN: 1573-904X
    Keywords: metronidazole ; 99mTc ; tumor hypoxia ; imaging ; radiosensitizer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The assessment of tumor hypoxia by imaging modality prior to radiation therapy would provide a rational means of selecting patients for treatment with radiosensitizers or bioreductive drugs. This study aimed to develop a 99mTc-labeled metronidazole (MN) using ethylene-dicysteine (EC) as a chelator and evaluate its potential use to image tumor hypoxia. Methods. EC was conjugated to amino analogue of MN using Sulfo-N-hydroxysuccinimide and l-ethyl-3-(3-dimethylaminopropyl) carbodiimide-HCl as coupling agents, the yield was 55%. Tissue distribution of 99mTc-EC-MN was determined in breast tumor-bearing rats at 0.5, 2, and 4 hrs. Planar imaging and whole-body autoradiograms were performed. The data was compared to that using 99mTc-EC (control), [l8F]fluoromisonidazole (FMISO) and [131I] iodomisonidazole (IMISO). Results. In vivo biodistribution of 99mTc-EC-MN in breast tumor-bearing rats showed increased tumor-to-blood and tumor-to-muscle ratios as a function of time. Conversely, tumor-to-blood values showed time-dependent decrease with 99mTc-EC in the same time period. Planar images and autoradiograms confirmed that the tumors could be visualized clearly with 99mTc-EC-MN from 0.5 to 4 hrs. There was no significant difference of tumor-to-blood count ratios between 99mTc-EC-MN and [131I]IMISO at 2 and 4 hrs postinjection. From 0.5 to 4 hrs, both 99mTc-EC-MN and [131I]IMISO have higher tumor-to-muscle ratios compared to [18]FMISO. Conclusions. It is feasible to use 99mTc-EC-MN to image tumor hypoxia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018836911013
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