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Digitale Medien

The prebiotic synthesis of deoxythymidine oligonucleotides (1974)

Stephen-Sherwood, E. ; Odom, D. G. ; Oró, J.

Springer

Journal of molecular evolution 3 (1974), S. 323-330

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ISSN: 1432-1432

Schlagwort(e): Prebiotic ; Polymerization ; Deoxythymidine-Oligonucleotides ; Deoxythymidine-Triphosphate ; Cyanamide ; 4-Amino-5-Imidazolecarboxamide

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Summary Deoxythymidine 5′-triphosphate in the presence of deoxythmidine 5′-phosphate, cyanamide and 4-amino-5-imidazole carboxamide polymerizes under drying conditions at moderate temperatures (60–90 °C) to yield oligonucleotides of up to four units in length. Enzymatic analysis indicated the majority of these oligomers contained natural 3′–5′ phosphodiester bonds. This reaction offers a possible method for the formation of deoxyoligonucleotides under primitive earth conditions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01796048

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