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  • 3H-8-MOP time activity curves  (1)
  • Accidental Trauma, Clinic Treatment  (1)
Document type
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 337 (1974), S. 851-851 
    ISSN: 1435-2451
    Keywords: Accidental Trauma, Clinic Treatment ; Autopsy ; Unfallverletzungen ; Klinische Befunde ; Sektionsbefunde
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden die Sektionsprotokolle von 939 Unfalltoten ausgewertet und mit den klinischen Unterlagen der Patienten verglichen, welche in klinische Behandlung kamen. Der Kliniker wird mit den Verletzungen der inneren Organe des Brust- und Bauchraumes seltener konfrontiert als der Pathologe. Bei der klinischen Diagnostik werden am häufigsten übersehen die Rippenserienfraktur und Wirbelfraktur, das intrakranielle Hämatom und eine Verletzung der parenchymatösen Bauchorgane.
    Notes: Summary The autopsy reports of 939 accidental deaths were evaluated and compared with the clinical data of those of the patients who had received clinical therapy. Intrathroacic and intra-abdominal injuries are seen less often by the clinician then by the pathologist. The lesions most frequently overlooked in clinical diagnosis are fractures of the ribs and of the vertebral spine, intracranial haematomas, and injuries of intra-abdominal parenchymatous organs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 273 (1982), S. 71-84 
    ISSN: 1432-069X
    Keywords: 3H-8-MOP ; DNA-RNA protein activity ; 3H-8-MOP time activity curves ; Rat organs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tritiated 8-methoxypsoralen was given perorally to rats in amounts corresponding to therapeutic human doses. The rats were exposed to UVA light or kept in darkness. None of the fractions (apart from 3H2O from the lens) examined changed their level of radioactivity under the influence of UVA light. Time-radioactivity curves were recorded for the skin, lens, residual eye, and the liver. Four fractions were measured: 3H2O, soluble pool, DNA-RNA, and protein. Tritiated water appeared already 1 h after ingestion, and attained maximum value 9–24 h after ingestion, indicating the efficiency with which the liver degrades 8-MOP. 3H-8-MOP and metabolites could be detected in the soluble pool in maximum amounts 2–3 h after the administration. Pretreatment with trypsin increased the concentration of 3H-8-MOP and metabolites; the origin of this extra radioactivity was the protein fraction. The 3H-8-MOP binding to DNA or RNA was studied by pretreatments of the homogenates with DNase or RNase followed by measurement of radioactivity in the TCA extracts. This indicated that no measurable amount of 3H-8-MOP had been bound to DNA or RNA. We conclude that 8-MOP administered to rats in amounts corresponding to human therapeutic doses does not bind to DNA or RNA in measurable amounts either after UV-light or in darkness. The experiments have shown proteins to be the main binding site in rat organs.
    Type of Medium: Electronic Resource
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