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  • 550 - Earth sciences  (2)
  • 3H-8-MOP time activity curves  (1)
  • 8-MOP  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 263 (1978), S. 37-46 
    ISSN: 1432-069X
    Keywords: Sister chromatid exchange ; 8-MOP ; ultraviolet light ; Schwester-chromatiden-Austausch ; 8-MOP, langwelliges UV-Licht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die unmittelbare Wirkung von 8-Methoxypsoralen (8-MOP) sowie von 8-MOP+langwelligem UV-Licht (UVA) auf Schwesterchromatiden-Austausch (SCE) wurde in einem in vitro-Experiment untersucht. Der SCE nach 8-MOP allein war signifikant erhöht, aber die Wirkung war wesentlich größer (50%) nach der Behandlung mit 8-MOP+UVA. Dazu wurden nach der Behandlung mit 8-MOP-Mitosen mit «gestreifter» Färbung der Chromosomen beobachtet. Die Veränderungen sind dosisabhängig und bilden möglicherweise die Ursache für die nach PUVA-Behandlung verminderte Zellteilung in Psoriasisflecken.
    Notes: Summary The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP+long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP+UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 273 (1982), S. 71-84 
    ISSN: 1432-069X
    Keywords: 3H-8-MOP ; DNA-RNA protein activity ; 3H-8-MOP time activity curves ; Rat organs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tritiated 8-methoxypsoralen was given perorally to rats in amounts corresponding to therapeutic human doses. The rats were exposed to UVA light or kept in darkness. None of the fractions (apart from 3H2O from the lens) examined changed their level of radioactivity under the influence of UVA light. Time-radioactivity curves were recorded for the skin, lens, residual eye, and the liver. Four fractions were measured: 3H2O, soluble pool, DNA-RNA, and protein. Tritiated water appeared already 1 h after ingestion, and attained maximum value 9–24 h after ingestion, indicating the efficiency with which the liver degrades 8-MOP. 3H-8-MOP and metabolites could be detected in the soluble pool in maximum amounts 2–3 h after the administration. Pretreatment with trypsin increased the concentration of 3H-8-MOP and metabolites; the origin of this extra radioactivity was the protein fraction. The 3H-8-MOP binding to DNA or RNA was studied by pretreatments of the homogenates with DNase or RNase followed by measurement of radioactivity in the TCA extracts. This indicated that no measurable amount of 3H-8-MOP had been bound to DNA or RNA. We conclude that 8-MOP administered to rats in amounts corresponding to human therapeutic doses does not bind to DNA or RNA in measurable amounts either after UV-light or in darkness. The experiments have shown proteins to be the main binding site in rat organs.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
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  • 4
    Publication Date: 2020-02-12
    Description: The sediment flux through Himalayan rivers directly impacts water quality and is important for sustaining agriculture as well as maintaining drinking-water and hydropower generation. Despite the recent increase in demand for these resources, little is known about the triggers and sources of extreme sediment flux events, which lower water quality and account for extensive hydropower reservoir filling and turbine abrasion. Here, we present a comprehensive analysis of the spatiotemporal trends in suspended sediment flux based on daily data during the past decade (2001–2009) from four sites along the Sutlej River and from four of its main tributaries. In conjunction with satellite data depicting rainfall and snow cover, air temperature and earthquake records, and field observations, we infer climatic and geologic controls of peak suspended sediment concentration (SSC) events. Our study identifies three key findings: First, peak SSC events (≥ 99th SSC percentile) coincide frequently (57–80%) with heavy rainstorms and account for about 30% of the suspended sediment flux in the semi-arid to arid interior of the orogen. Second, we observe an increase of suspended sediment flux from the Tibetan Plateau to the Himalayan Front at mean annual timescales. This sediment-flux gradient suggests that averaged, modern erosion in the western Himalaya is most pronounced at frontal regions, which are characterized by high monsoonal rainfall and thick soil cover. Third, in seven of eight catchments, we find an anticlockwise hysteresis loop of annual sediment flux variations with respect to river discharge, which appears to be related to enhanced glacial sediment evacuation during late summer. Our analysis emphasizes the importance of unconsolidated sediments in the high-elevation sector that can easily be mobilized by hydrometeorological events and higher glacial-meltwater contributions. In future climate change scenarios, including continuous glacial retreat and more frequent monsoonal rainstorms across the Himalaya, we expect an increase in peak SSC events, which will decrease the water quality and impact hydropower generation.
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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