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  • 1
    Electronic Resource
    Electronic Resource
    Susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ α Arg 52 and HLA-DQ β non-Asp 57 alleles (1992)
    Springer
    Diabetologia 35 (1992), S. 583-588 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; HLA-DQα ; Arg 52 ; HLA-DQβ non-Asp 57 ; Spain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HLA-DQ α and β alleles were chosen as the most sensitive Type 1 (insulin-dependent) diabetes mellitus susceptibility markers for evaluating the disease associations and Type 1 diabetes risk in a population-based registry from Madrid. The absence of aspartic acid in position 57 of the DQ β chain (non-Asp 57), and the presence of arginine in position 52 of the DQ a chain (Arg 52) were found to be reliable markers of Type 1 diabetes susceptibility among the Spanish population, with significantly higher frequencies among the cases of Type 1 diabetes compared to randomly selected non-diabetic control subjects from the general Madrid population. While non-Asp 57 homozygosity conferred an absolute risk of 32.3 per 100,000 per year and Arg 52 of 31.5 per 100,000 per year, the risk for double homozygotes for both non-Asp 57 and Arg 52 was estimated as 101.7 per 100,000 per year. Individuals homozygous for only one of these alleles, and heterozygous at the other locus, had a markedly lower Type 1 diabetes risk (12.8 per 100,000 per year), approximating the general population incidence for Madrid. Thus, susceptibility to Type 1 diabetes in Spanish patients is associated, quantitatively, with non-Asp 57 DQ β and Arg 52 DQ α alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400488
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  • 2
    Electronic Resource
    Electronic Resource
    Seroepidemiological survey of Q fever in León Province, Spain (1996)
    Springer
    European journal of epidemiology 12 (1996), S. 245-250 
    Details
    ISSN: 1573-7284
    Keywords: Coxiella burnetii ; Q fever ; Sero-epidemiology ; Spain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A seroepidemiological survey, using an indirect immunofluorescence test against Coxiella burnetii (antigenic phase II), was carried out in León province, north-western Spain. A total of 406 serum samples was collected from people (from 15 to more than 65 years old) living in a rural environment during the winter and spring of 1994. The overall prevalence was 40.6%, titres ranged from 1:80 to 1:640, and a titre of 1:80 was encountered among 60.6% of positive samples. A significant higher prevalence was observed among males globally, as well as among those aged 15–44 and 45–64 years old; however, no difference was encountered among males and females older than 64 years. In the same way, a significant higher Q fever prevalence was observed among individuals having occupations related to agriculture and among those having close relationship with animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00145413
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  • 3
    Electronic Resource
    Electronic Resource
    The evolution of breast cancer mortality and morbidity in Spain (1977–1988) (1996)
    Springer
    European journal of epidemiology 12 (1996), S. 351-358 
    Details
    ISSN: 1573-7284
    Keywords: Breast cancer ; Mortality ; Morbidity ; Spain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A study of breast cancer mortality and cancer morbidity has been carried out in Spain recently for the period 1977–1988, covering the population of the 17 Autonomous Communities and 50 provinces of the country. Data was obtained from INE, Instituto Nacional de Estadistica (National Institute of Statistics), with age standardization using the indirect method. The different Autonomous Communities and provinces were compared in order to establish possible significant differences. The crude mean mortality rate was 21 cases per 100,000 inhabitants/year; Las Palmas, Gerona, Barcelona, the Balearic Islands, Navarra and Zaragoza have the highest mortality rates, with a proportional increment of 54% in that period. The crude national mean morbidity rate for the considered period was 64.0 cases per 100,000 inhabitants, and the proportional increment 180%. According to provincial figures, Alava had the highest fitted mean morbidity rate, 135 cases per 100,000 inhabitants, whilst the highest fitted mean rate was Las Palmas (28 cases/100,000 inhabitants), and the highest proportional increment was the rate for the province of Huesca (169%). When using the ANOVA test on the mean rate of the period, for mortality as well as morbidity, we observed significant differences among provinces and among Autonomous Communities (p ⩽ 0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00145297
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  • 4
    Electronic Resource
    Electronic Resource
    Stability of isomeric Na n clusters (1991)
    Springer
    The European physical journal 19 (1991), S. 141-143 
    Details
    ISSN: 1434-6079
    Keywords: 31.20.Sy ; 36.40. +d
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A method which combines density functional theory and the use of pseudopotentials is applied to obtain ground state and low-lying metastable geometries of Na n clusters (7≤n≤40). The large variation in the magnitude of energy gaps between isomers suggests that the melting temperature is not a simple monotonous function of size. A detailed study of the differences between electronically stabilized (n=8, 20, 40) and structurally stabilized (n=13) clusters suggests some clues to understand the intriguing behaviour of Na13.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01448275
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  • 5
    Electronic Resource
    Electronic Resource
    Evaporation rates of hot sodium clusters (1991)
    Springer
    The European physical journal 20 (1991), S. 119-122 
    Details
    ISSN: 1434-6079
    Keywords: 36.40. + d ; 31.20.Sy ; 65.50. + m ; 63.70. + h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A scheme based in density functional theory with pseudopotentials is used to obtain the normal modes of vibration of Na n clusters (4 ≤n ≤ 22). The monomer and dimer evaporation rates from thermally excited clusters are obtained in this harmonic approximation. The time evolution of the abundance spectra from an initial uniform mass distribution of hot clusters is studied and its influence in the experimentally observed spectra is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01543952
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