ISSN:
1432-1912
Keywords:
3′,5′-Cyclic Adenosine Monophosphate
;
Adenylate Cyclase
;
Tyrosine-3-Mono-Oxygenase
;
Monoamine Oxidase
;
Choline Acetyltransferase
;
Denervated Adrenal Medulla
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Unilateral adrenal denervation caused a gradual decrease of adenylate cyclase activity in rat adrenal medulla. The extent of the increase in adrenal medullary 3′,5′-cyclic adenosine monophosphate (cAMP) content elicited by injections of carbamylcholine declined gradually following adrenal denervation. Three or nine days after denervation carbamylcholine caused rise of cAMP and a delayed increase of tyrosine-3-mono-oxygenase (TH) activity of similar magnitude in intact and denervated adrenal medullae. However, after an interval of 15 days or longer following denervation the increase in TH activity elicited by carbamylcholine was greatly reduced. These results support previous proposals that cAMP is involved as a second messenger in the trans-synaptic induction of TH.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00510452
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