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  • 13C and 15N assignments  (1)
  • 3H-Uridine uptake  (1)
  • Development  (1)
  • S-100  (1)
Document type
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    NCAM in developing mouse gonads and ducts (1991)
    Springer
    Anatomy and embryology 184 (1991), S. 541-548 
    Details
    ISSN: 1432-0568
    Keywords: Cell adhesion ; Gonads ; Development ; NCAM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of theNeuralCell AdhesionMolecule, NCAM, in mouse gonads and ducts was studied from fetal life to maturity. The methods used were immunocytochemical staining and Western blotting. The immunocytochemical studies showed that the only structures that remain NCAM-positive throughout life were the mesonephric-derived rete ovarii and rete testis. Also in the fetal gonads some somatic cell lining the groups of differentiating germ cells were stained. In the immature as well as in the mature ovary the granulosa cells and oocytes of growing and large follicles — but not of small follicles — were stained. A particularly strong staining of the cytoplasm of the oocyte, healthy as well as atretic, was seen. All cells of the testis remained negative except for weakly stained residual bodies and late spermatids. At all ages the male ducts showed only weak staining, whereas in the female Müllerian duct the epithelium became strongly positive at puberty. The stroma of the Müllerian duct was positive during a transitory period around day 16 of fetal life in both sexes. One-dimensional gel immunoblotting of total protein from gonads, rete and ducts from immature and mature mice showed that only the two largest isoforms of NCAM (NCAM-A and NCAM-B) were present. The gonads and the rete of both sexes and the adult uterus expressed only NCAM-B, whereas NCAM-A was also detected in the adult epididymis. The present findings suggest that NCAM may be involved in the normal development and formation of both the gonads and ducts. In particular, NCAM may play a part in sustaining the integrity of the rete testis, thus ensuring the pathway for spermatozoa from the testis to the epididymis. Furthermore this cell adhesion molecule may also be important for follicular growth and differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00942576
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Letter to the Editor: 1H, 13C and 15N assignments of the neural cell adhesion molecule module-1 (1999)
    Springer
    Journal of biomolecular NMR 14 (1999), S. 185-186 
    Details
    ISSN: 1573-5001
    Keywords: 1H ; 13C and 15N assignments ; module-1 ; neural cell adhesion molecule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008390005334
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-dose treatment of rats with perphenazine enanthate (1976)
    Springer
    Psychopharmacology 50 (1976), S. 305-307 
    Details
    ISSN: 1432-2072
    Keywords: Perphenazine ; Nerve cell counts ; Basal ganglia ; Cortex ; Neuroleptic treatment ; 3H-Uridine uptake ; Brain specific proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previously we demonstrated an approximately 20% loss of nerve cells in the basal ganglia of rats following treatment with perphenazine enanthate 3.4 mg/kg s.c. every 2nd week during 12 months. If the treatment period was only 2 or 3 months no significant differences were found. In the present investigation a treatment period of 6 months and a 10-fold higher dose of perphenazine enanthate (40 mg/kg s.c. every 2nd week) was used. No significant differences from control animals were found by cell counting in the basal ganglia and the cortex, by electron microscopy investigation of the same structures, or by quantitative immunoelectrophoresis of proteins from the corpus striatum and the cortex. The uptake of 3H-uridine measured by autoradiography in the cortex and in the liver was, however, 20–50% higher in the experimental group. The influences of dose level, duration of treatment period, and animal age are discussed and correlated to the clinical syndrome of tardive dyskinesia seen in patients treated with neuroleptics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426849
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Biochemical correlates to cortical dysplasia, gliosis, and astrocytoma infiltration in human epileptogenic cortex (1993)
    Springer
    Neurochemical research 18 (1993), S. 511-518 
    Details
    ISSN: 1573-6903
    Keywords: Epilepsy ; human ; temporal cortex ; gliosis ; astrocytoma, mild cortical dysplasia ; neuron specific enolase ; neurofilament polypeptides ; glial fibrillary acidic protein ; S-100 ; neural cell adhesion molecule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy or for disorders not related to epilepsy. The histopthological diagnosis of the epileptic cases was: MCD (mild cortical dysplasia, microdysgenesis), gliosis, astrocytoma, ganglioglioma, oligodendroglioma and single cases. The concentration in non-epileptic white matter, in per cent of that in grey matter was: NSE, 85; GFA, 175; S-100, 117; NCAM, 43; NF 68,227 and NF 200, 173. The concentration of NSE as well as of GFA was close to normal in the specimens of the MCD and gliosis groups and of one subgroup of the astrocytomas. There was a striking inverse relationship of the GFA vs the NSE concentrations in the whole material. The concentrations of S-100 showed no such inverse relationship to NSE levels. In all the epileptic groups, total NCAM was lower than 50% of that of the non-epileptic group. The mean NF 68 and NF 200 concentration in the gliosis and astrocytoma groups was 75% of the of the non-epileptic group while the corresponding value for the MCD group was 50%. There was a positive correlation of immunochemically determined GFA and the histopathological gliosis score in the samples of epileptogenic cortex. There was no correlation between the concentration of GFA in the samples and the duration of epilepsy. The concentration of neuronal markers was relatively unaffected in the cortex of most patients with epilepsy related to MCD, gliosis and even to astrocytoma infiltration, even after years of seizures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00967255
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    Paper (German National Licenses)
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