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  • Xenotransplantation  (2)
  • urinary albumin excretion  (2)
  • 10-(Z)-cinnamoyl-catalpol  (1)
  • AT_II-054_25PC; ATII_USA; Atlantis II (1963); Core; CORE; P07; Panama Margin; PC; Piston corer  (1)
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  • 1
    facet.materialart.
    Unknown
    Age determination of sediment cores from the Panama Basin
    PANGAEA
    In:  Supplement to: Pedersen, Thomas F; Nielsen, B; Pickering, Mark (1991): Timing of Late Quaternary productivity pulses in the Panama Basin and implications for atmospheric CO2. Paleoceanography, 6(6), 657-677, https://doi.org/10.1029/91PA02532
    Details
    Publication Date: 2023-05-12
    Description: High-resolution percent Corg and delta18Oforam records obtained from Panama Basin core Atlantis II 54-25PC and additional data from nearby core P7 show that enhanced burial of organic carbon has characterized every major glacial period for the last 500 kyr in that area. Both Corg concentration and mass accumulation rate profiles exhibit a sawtooth pattern with maxima occurring typically in the later stages of glacial periods. Comparison with dust records suggests that the carbon accumulation rate profile reflects both the upwelling history and a variable rate of iron input during the late Quaternary. The sawtooth character may derive from increased wind velocities and rates of upwelling during glacials which are indirectly related to ice volume (Sarnthein et al., 1988). The rapid decline in export production at the end of glacials in the equatorial Pacific may be attributed to the retreat of ice sheets (thus reduced wind velocities and upwelling) coupled with a coincident decline in atmospheric dust load and/or delivery rate. The Corg accumulation rate profiles do not correlate well with atmospheric CO2 records. For example, atmospheric CO2 was already at a minimum 40 kyr ago when production in the Panama Basin began increasing dramatically, commensurate with an increase in global dust levels. Using the relationship between the degree of photosynthetic fractionation and the concentration of free CO2 in the surface ocean postulated by Popp et al. (1989), delta13Corg measurements made on core P7 show that Panama Basin surface waters have been supplying CO2 to the atmosphere continually for at least the last 50 kyr. There is no evidence for a flux of CO2 into the surface ocean in this area at any time during this period despite the higher production. If the Panama Basin cores are representative of the eastern and central equatorial Pacific, then these observations weaken the influence on CO2 drawdown postulated for increased glacial productivity at low latitudes.
    Keywords: AT_II-054_25PC; ATII_USA; Atlantis II (1963); Core; CORE; P07; Panama Margin; PC; Piston corer
    Type: Dataset
    Format: application/zip, 2 datasets
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 2
    Electronic Resource
    Electronic Resource
    Iridoid glucosides from Utricularia australis and Pinguicula vulgaris (lentibulariaceae)
    Amsterdam : Elsevier
    Phytochemistry 24 (1985), S. 2281-2283 
    Details
    ISSN: 0031-9422
    Keywords: 10-(Z)-cinnamoyl-catalpol ; Lentibulariaceae ; Pinguicula vulgaris ; Utricularia australis ; aucubin ; catalpol ; gardoside ; globularin ; iridoid glucosides ; mussaenosidic acid, 6-deoxycatalpol ; taxonomy.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)83027-7
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Hamster to rat kidney transplantation: technique, functional outcome and complications (1996)
    Springer
    Urological research 24 (1996), S. 211-216 
    Details
    ISSN: 1434-0879
    Keywords: Rats ; Hamster ; Microsurgery ; Kidney transplantation ; Renal function ; Xenotransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hamster to rat kidney transplantation has only recently been introduced as model of concordant xenografting. The kidney model offers unique possibilities for studying both immunological and functional aspects of xenografts as opposed to the widely used heterotopic heart model. This article provides a detailed description of surgical technique as well as data on functional outcome and complications. The renal artery with a small segment of the aorta is sutured end-to-side to the abdominal aorta of the recipient, and the renal vein is anastomosed end-to-side to the inferior vena cava. The urinary system is reconstructed by bladder-to-bladder anastomosis. Xenografts will maintain close to normal serum-creatinine levels for 2–3 days, after which they are rejected. Complications occurred in 22% of xenografts. Postrenal obstruction due to severe hematuria or ureter stenosis was the most frequent problem encountered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295894
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effect of octreotide and insulin on manifest renal and glomerular hypertrophy and urinary albumin excretion in long-term experimental diabetes in rats (1995)
    Springer
    Diabetologia 38 (1995), S. 135-144 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; octreotide ; urinary albumin excretion ; renal hypertrophy ; kidney morphology ; IGF-I ; IGFBPs ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes, octreotide treatment was given for 3 weeks after an untreated diabetic period of 3 or 6 months. In addition, following 6 months of diabetes, a group of diabetic rats was treated with insulin for 3 weeks. Renal and glomerular hypertrophy, and increased urinary albumin excretion were observed in diabetic rats compared to non-diabetic control rats from 3 months and throughout the study period. Octreotide treatment did not affect body weight, food intake, blood glucose or serum fructosamine levels. We observed no effect of octreotide treatment on renal and glomerular hypertrophy or urinary albumin excretion compared to placebotreated diabetic rats. Insulin treatment for 3 weeks after 6 months of untreated diabetes normalized blood glucose and serum fructosamine levels, and furthermore renal hypertrophy was significantly diminished compared to the placebo-treated diabetic rats. However, insulin treatment had no effect on glomerular hypertrophy or urinary albumin excretion. In conclusion, octreotide treatment for 3 weeks following an untreated diabetic period of 3 or 6 months is unable to reduce the increased renal and glomerular volume or urinary albumin excretion. However, insulin treatment for 3 weeks with induction of euglycaemia diminishes the renal hypertrophy but has no effect on glomerular volume or urinary albumin excretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400087
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Effect of octreotide and insulin on manifest renal and glomerular hypertrophy and urinary albumin excretion in long-term experimental diabetes in rats (1995)
    Springer
    Diabetologia 38 (1995), S. 135-144 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetes mellitus ; octreotide ; urinary albumin excretion ; renal hypertrophy ; kidney morphology ; IGF-I ; IGFBPs ; rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes, octreotide treatment was given for 3 weeks after an untreated diabetic period of 3 or 6 months. In addition, following 6 months of diabetes, a group of diabetic rats was treated with insulin for 3 weeks. Renal and glomerular hypertrophy, and increased urinary albumin excretion were observed in diabetic rats compared to non-diabetic control rats from 3 months and throughout the study period. Octreotide treatment did not affect body weight, food intake, blood glucose or serum fructosamine levels. We observed no effect of octreotide treatment on renal and glomerular hypertrophy or urinary albumin excretion compared to placebo-treated diabetic rats. Insulin treatment for 3 weeks after 6 months of untreated diabetes normalized blood glucose and serum fructosamine levels, and furthermore renal hypertrophy was significantly diminished compared to the placebo-treated diabetic rats. However, insulin treatment had no effect on glomerular hypertrophy or urinary albumin excretion. In conclusion, octreotide treatment for 3 weeks following an untreated diabetic period of 3 or 6 months is unable to reduce the increased renal and glomerular volume or urinary albumin excretion. However, insulin treatment for 3 weeks with induction of euglycaemia diminishes the renal hypertrophy but has no effect on glomerular volume or urinary albumin excretion. [Diabetologia (1995) 38: 135–144]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400087
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Treatment with total lymphoid irradiation, cyclosporin A and a monoclonal anti-T-cell antibody in a hamster-to-rat heart transplantation model: Graft survival and morphological analysis (1990)
    Springer
    Transplant international 3 (1990), S. 36-40 
    Details
    ISSN: 1432-2277
    Keywords: Xenotransplantation ; Total lymphoid irradiation, in xenotransplantation ; Immunosuppression, in xenotransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment with preoperative total lymphoid irradiation and post-transplant cyclosporin A has been shown to have a synergistic effect on graft survival in allo-and xenotransplantation. Specific monoclonal antibodies against T cells and T cell subpopulations could offer new ways of preventing graft rejection in xenotransplantation. Graft survival and histology were examined after total lymphoid irradiation plus cyclosporin A treatment versus cyclosporin A plus a monoclonal antibody in a concordant, heterotopic, hamster-to-rat heart transplantation model. Preoperative total lymphoid irradiation was given at a dose of 1.25 Gy, 12 times over a period of 3 weeks. Cyclosporin A at a dose of 12.5 mg/kg per day was administered perorally and OX-19, a pan T cell monoclonal antibody, was given as intraperitoneal injections at doses of 100 μg or 500 μg/kg per day from day 0 until graft rejection. While total lymphoid irradiation alone prolonged graft survival to 9.4 days, total lymphoid irradiation plus cyclosporin A extended graft survival to a mean of 22 days. Cyclosporin alone or combined with the monoclonal antibody could not increase graft survival significantly when compared to untreated animals, which rejected their grafts within 3.7 days. Vascular rejection was the characteristic morphological finding, even after some weeks of excellent graft function. In conclusion, total lymphoid irradiation and cyclosporin A had a synergistic effect on graft survival in this concordant xenotransplantation model, although recent impressive results from other groups could not be reproduced. Total lymphoid irradiation combined with cyclosporin A appears to delay a primary humoral graft rejection, while the mechanism of rejection, judged by histology, stays the same.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333201
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    Paper (German National Licenses)
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