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  • 1
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    Double-blind randomised controlled trial of the independent and synergistic effect of Spirulina maxima with exercise (ISESE) on general fitness, lipid profile and redox status in overweight and obese subjects: study protocol (2017)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2017-06-24
    Description: Introduction In order to reduce cardiovascular disease risk factors, a healthy diet must include dietary antioxidants from different sources (eg, Spirulina maxima ) and regular practice of exercise should be promoted. There is some evidence from animal studies that S. maxima and exercise decrease cardiovascular disease risks factors. However, very few studies have proved the independent or synergistic effect of S. maxima plus exercise in humans. This study attempts to address the independent and synergistic effects in overweight and obese subjects participating in a systematic physical exercise programme at moderate intensity on general fitness, plasma lipid profile and antioxidant capacity. Methods and analysis Using a randomised, double-blind, placebo-controlled, counterbalanced crossover study design, 80 healthy overweight and obese subjects will be evaluated during a 12-week isoenergetic diet accompanied by 4.5 g/day S. maxima intake and/or a physical systematic exercise programme at moderate intensity. Body composition, oxygen uptake, heart rate, capillary blood lactate, plasma concentrations of triacylglycerols, total, low-density and high-density lipoprotein cholesterol, antioxidant status, lipid oxidation, protein carbonyls, superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione reductase and paraoxonase will be assessed. Ethics and dissemination This study and all the procedures have been approved by the Universidad Autonoma de Ciudad Juarez Bioethics Committee. Findings will be disseminated through peer-reviewed journals, national and international conferences. Trial registration number ClinicalTrials.gov: NCT02837666.
    Keywords: Open access, Cardiovascular medicine
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 2
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    Impact of renin-angiotensin system inhibitors on clinical outcomes and ventricular remodelling after transcatheter aortic valve implantation: rationale and design of the RASTAVI randomised multicentre study (2018)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2018-02-14
    Description: Introduction Transcatheter aortic valve implantation (TAVI) as a treatment in severe aortic stenosis (AS) is an excellent alternative to conventional surgical replacement. However, long-term outcomes are not benign. Renin-angiotensin system (RAS) blockade has shown benefit in terms of adverse remodelling in severe AS and after surgical replacement. Methods and analysis The RAS blockade after TAVI (RASTAVI) trial aims to detect if there is a benefit in clinical outcomes and ventricular remodelling with this therapeutic strategy following the TAVI procedure. The study has been designed as a randomised 1:1 open-label study that will be undertaken in 8 centres including 336 TAVI recipients. All patients will receive the standard treatment. The active treatment group will receive ramipril as well. Randomisation will be done before discharge, after signing informed consent. All patients will be followed up for 3 years. A cardiac magnetic resonance will be performed initially and at 1 year to assess ventricular remodelling, defined as ventricular dimensions, ejection fraction, ventricular mass and fibrosis. Recorded events will include cardiac death, admission due to heart failure and stroke. The RASTAVI Study will improve the management of patients after TAVI and may help to increase their quality of life, reduce readmissions and improve long-term survival in this scenario. Ethics and dissemination All authors and local ethics committees have approved the study design. All patients will provide informed consent. Results will be published irrespective of whether the findings are positive or negative. Trial registration number NCT03201185 .
    Keywords: Open access, Cardiovascular medicine
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 3
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    Accurate Hypocenter Determination in Lesser Antilles Region from the Sismantilles I Experimen (2012)
    Details
    Publication Date: 2020-12-21
    Description: In this study, we present results of the investigation programme SISMANTILLES I, conducted from November 1999 to January 2002, on the Lesser Antilles Arc. We analyzed seismicity by using the data recorded by a combined on- and offshore network that integrated the local volcano-seismological observatories of the Institut de Physique du Globe de Paris (IPGP). The SISMANTILLES I landward network comprised 43 three-component temporary stations. To improve azimuth coverage in earthquake location, it was complemented by 31 OBS. A data-set of 155 well located earthquakes has been used to study the relationship between tectonic structures and seismicity. In particular, to obtain precise hypocenter locations, we applied the concept of minimum 1D model which incorporates the iterative simultaneous inversion of velocity and hypocenter parameters. To partly estimate the huge structural heterogeneity of the Lesser Antilles Subduction Zone, the minimum 1D model is complemented by station corrections which take into account near surface velocity heterogeneity. The relocated hypocenters improve our knowledge on the subduction zone since they have smaller uncertainties with respect to the permanent array locations. The vertical depth sections, perpendicular to the arc, will help define the slab structure and the dip angle.
    Description: Submitted
    Description: Saint Petersburg, Russia
    Description: 3.2. Tettonica attiva
    Description: open
    Keywords: Seismic Interpretation ; Seismic Data Acquisition and Processing ; Near-Surface structure ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Extended abstract
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  • 4
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    Revised slip rates for the Alpine fault at Inchbonnie: Implications for plate boundary kinematics of South Island, New Zealand (2010)
    Geological Society of America
    Details
    Publication Date: 2017-04-04
    Description: The northeast-striking, dextral-reverse Alpine fault transitions into the Marlborough Fault System near Inchbonnie in the central South Island, New Zealand. New slip-rate estimates for the Alpine fault are presented following a reassessment of the geomorphology and age of displaced late Holocene alluvial surfaces of the Taramakau River at Inchbonnie. Progressive avulsion and abandonment of the Taramakau floodplain, aided by fault movements during the late Holocene, have preserved a left-stepping fault scarp that grows in height to the northeast. Surveyed dextral (22.5 ± 2 m) and vertical (4.8 ± 0.5 m) displacements across a left stepover in the fault across an alluvial surface are combined with a precise maximum age from a remnant tree stump (≥1590–1730 yr) to yield dextral, vertical, and reverse-slip rates of 13.6 ± 1.8, 2.9 ± 0.4, and 3.4 ± 0.6 mm/yr, respectively. These values are larger (dextral) and smaller (dip slip) than previous estimates for this site, but they refl ect advances in the local chronology of surfaces and represent improved time-averaged results over 1.7 k.y. A geological kinematic circuit constructed for the central South Island demonstrates that (1) 69%–89% of the Australian-Pacific plate motion is accommodated by the major faults (Alpine-Hope-Kakapo) in this transitional area, (2) the 50% drop in slip rate on the Alpine fault between Hokitika and Inchbonnie is taken up by the Hope and Kakapo faults at the southwestern edge of the Marlborough Fault System, and (3) the new slip rates are more compatible with contemporary models of strain partitioning presented from geodesy.
    Description: Published
    Description: 139-152
    Description: 3.2. Tettonica attiva
    Description: 4.2. TTC - Modelli per la stima della pericolosità sismica a scala nazionale
    Description: N/A or not JCR
    Description: reserved
    Keywords: Alpine fault ; plate boundary ; slip rate ; New Zealand ; 04. Solid Earth::04.04. Geology::04.04.01. Earthquake geology and paleoseismology ; 04. Solid Earth::04.04. Geology::04.04.02. Geochronology ; 04. Solid Earth::04.04. Geology::04.04.03. Geomorphology ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.04. Plate boundaries, motion, and tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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