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  • 1
    Electronic Resource
    Electronic Resource
    In situ hybridization of muscle mitochondrial mRNA in mitochondrial myopathies (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 1-6 
    Details
    ISSN: 1432-0533
    Keywords: In situ hybridization ; Mitochondrial DNA ; Mitochondrial myopathy ; Ophthalmoplegia ; Cytochromec oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine whether a mitochondrial mRNA deficiency exists in mitochondrial myopathies, muscle biopsies from a patient with chronic progressive external ophthalmoplegia (CPEO) and a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) were studied using in situ hybridization. Histochemistry and immunohistochemistry were performed along with hybridization. Hybridization reactions were widely distributed over the sarcoplasm of all muscle fibers in the patient with MELAS. In the patient with CPEO, 80% of the fibers showed a marked decrease in density of autoradiographic grains. This marked decrease corresponded to the histochemical and immunohistochemical findings of a very weak staining of cytochromec oxidase (CCO). The isotope-labeled cDNA probe used in in situ hybridization in this study complements a part of subunit I of CCO and a part of subunit II of complex I in the mitochondrial gene. Our results suggest a defect in the mRNA in this CPEO patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662630
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Single-crystal growth and anisotropic electrical properties of (La1− xCa x )2CaCu2O6 (1994)
    Springer
    Journal of superconductivity 7 (1994), S. 313-318 
    Details
    ISSN: 1572-9605
    Keywords: (La, Ca)2CaCu2O6, single crystal ; TSFZ technique ; oxygen HIP ; electrical anisotropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Large single crystals of (La1−x Ca x )2CaCu2O6 were synthesized by the travelling solvent floating zone (TSFZ) technique. The dimension of the grown boules was typically 4 mmφ×30 mm long with thec-axis perpendicular to the growth direction. After oxygen loading at 1080°C in 400 atm of O2, they became superconductive with a sharp transition at around 50 K. The resistivity was metallic both along thec-axis and within theab-plane, with an anisotropy ratio ofγ 2≡(ρ c/ρ ab ) ∼ 50 which is almost independent of temperature. Details of the crystal growth, heat treatment procedures, and the results of electrical and magnetic property measurements are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00724560
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    Paper (German National Licenses)
    Fulltext
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