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  • 1
    Online Resource
    Online Resource
    Dynamic regulation of TRIM37 expression in macrophages facilitates pancreatic cancer development
    The American Association of Immunologists ; 2020
    In:  The Journal of Immunology Vol. 204, No. 1_Supplement ( 2020-05-01), p. 164.17-164.17
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 204, No. 1_Supplement ( 2020-05-01), p. 164.17-164.17
    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer as the overall five-year survival rate was less than 5%. More than 90% of PDAC patients harbor Kras mutation, but only mutant Kras is insufficient to give rise to PDAC. Inflammation is essential to cooperate with mutant Kras for the initiation of pancreatic precancerous lesion, and attracted M1-polarized macrophages-induced inflammation are known to contribute to the process. Among TRIM family proteins, TRIM37 is the only protein containing MATH domain that endows it being able to interact with proteins containing TRAF domain, indicating its possible role in regulating pattern recognition receptor-, TNFR- and cytokine-mediated signaling pathways. We have observed that, when TRIM37 was knocked-down, macrophage cytokines production, such as IL-1β, IFN-β, IL-12, TNF-a, IL-6 and CCL-2 in response to LPS was reduced, and the regulation was both epigenetically and non-epigenetically. Interestingly, pro-inflammatory cytokines also upregulated TRIM37 expression in macrophages. Thus our data implicated that upregulated TRIM37 that positively regulate macrophage cytokine production might contribute to the initiation of PDAC. However, when macrophages were co-cultured with pancreatic cancer cells, the expression level of TRIM37 in macrophages were downregulated, this led to the loss of its ability in maintaining macrophages in a stable M1 phenotype, and instead, skewing the macrophages into a M2 phenotype, which promotes cancer progression. In conclusion, our data demonstrate that during pancreatic cancer development, the expression of TRIM37 in macrophages are differential regulated to favor cancer development and progression.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.204.Supp.164.17
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2020
    detail.hit.zdb_id: 1475085-5
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  • 2
    Online Resource
    Online Resource
    Genomic Organization of the Chicken CD8 Locus Reveals a Novel Family of Immunoreceptor Genes
    The American Association of Immunologists ; 2007
    In:  The Journal of Immunology Vol. 178, No. 5 ( 2007-03-01), p. 3023-3030
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 178, No. 5 ( 2007-03-01), p. 3023-3030
    Abstract: The genomic organization of the chicken CD8α gene was investigated to determine the basis of its polymorphism. Contiguous to the CD8α gene we identified multiple DNA blocks possessing sequences homologous to CD8α. Gene conversions and recombination over evolutionary time among CD8α and these CD8α homologous genes seem to account for the observed polymorphism. Furthermore, these CD8α-like DNAs encode a distinct multigene family of immunoreceptors that have a charged or polar residue in place of the interspecies-conserved CD8α transmembrane proline residue and a short cytoplasmic tail nonhomologous to CD8α. The identification of this novel multigene family with an organization reminiscent of human killer Ig-like receptors raises compelling questions on their evolutionary relationship among immunoreceptors.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.178.5.3023
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2007
    detail.hit.zdb_id: 1475085-5
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  • 3
    Online Resource
    Online Resource
    Development of Th1 and Th2 Populations and the Nature of Immune Responses to Hepatitis B Virus DNA Vaccines Can Be Modulated by Codelivery of Various Cytokine Genes
    The American Association of Immunologists ; 1998
    In:  The Journal of Immunology Vol. 160, No. 3 ( 1998-02-01), p. 1320-1329
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 160, No. 3 ( 1998-02-01), p. 1320-1329
    Abstract: In this study, we provide direct evidence that the magnitude and nature of the immune response to a DNA vaccine can be differentially regulated by codelivery of various mouse cytokine genes. Mice immunized with a hepatitis B virus (HBV) DNA vaccine and the IL-12 or IFN-γ gene exhibited a significant enhancement of Th1 cells and increased production of anti-HBV surface IgG2a Ab, as well as a marked inhibition of Th2 cells and decreased production of IgG1 Ab. In contrast, coinjection of the IL-4 gene significantly enhanced the development of specific Th2 cells and increased production of IgG1 Ab, whereas Th1 differentiation and IgG2a production were suppressed. Coinjection of the IL-2 or the granulocyte-macrophage-CSF gene enhanced the development of Th1 cells, while the development of Th2 cells was not affected, and the production of IgG1 and IgG2a Ab were both increased. The CTL activity induced by HBV DNA vaccination was most significantly enhanced by codelivery of the IL-12 or IFN-γ gene, followed by the IL-2 or granulocyte-macrophage-CSF gene, whereas codelivery of the IL-4 gene suppressed the activity. When challenged with HBV surface Ag (HBsAg)-expressing syngeneic tumors, significant reduction of tumor growth was observed in mice that were coadministered the IL-12 gene but not the IL-4 gene. Taken together, these results demonstrate that application of a cytokine gene in a DNA vaccine formulation can influence the differentiation of Th cells as well as the nature of an immune response and may thus provide a strategy to improve its prophylactic and therapeutic efficacy.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.160.3.1320
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 1998
    detail.hit.zdb_id: 1475085-5
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  • 4
    Online Resource
    Online Resource
    Helicobacter pylori -derived heat shock protein 60 increases the induction of regulatory T cells (P3365)
    The American Association of Immunologists ; 2013
    In:  The Journal of Immunology Vol. 190, No. 1_Supplement ( 2013-05-01), p. 202.5-202.5
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 190, No. 1_Supplement ( 2013-05-01), p. 202.5-202.5
    Abstract: Regulatory T cells have been shown to highly infiltrate the H. pylori-infected gastric mucosa. Treg cells suppress the host’s immune responses to H. pylori and dominate during persistent infection. H. pylori-derived HSP60 is one important virulence factor that promotes malignant tumorigenesis. This study further investigated the role of HpHSP60 in immunosuppression, and its activity was found to correlate with the induction of Treg cells. To determine the effects of HpHSP60 on immunosuppression, human peripheral blood mononuclear cells were treated with or without HpHSP60 in the presence of anti-CD3 mAb to determine the effect of HpHSP60 on proliferation. We subsequently asked whether proliferative inhibition correlates with the induction of Treg cells. Finally, the mechanism through which HpHSP60 induces Treg cells was identified. HpHSP60 decreased the expression of CDK4 to significantly slow the proliferation of mitogen-stimulated T cells, which correlated with the induction of Treg cells. Moreover, secretion of IL-10 and TGF-β by monocytic cells was essential to the induction of HpHSP60-induced Treg cells. In summary, we propose that HpHSP60 can act on macrophages to trigger the expression of IL-10 and TGF-β, resulting in an increase in Treg cells and the proliferative inhibition of T cells.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.190.Supp.202.5
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2013
    detail.hit.zdb_id: 1475085-5
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  • 5
    Online Resource
    Online Resource
    Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection
    The American Association of Immunologists ; 2017
    In:  The Journal of Immunology Vol. 199, No. 8 ( 2017-10-15), p. 2834-2844
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 199, No. 8 ( 2017-10-15), p. 2834-2844
    Abstract: Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome and is endemic to tropical and subtropical regions of the world. Our previous studies showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive with host Ags and trigger anti–DENV NS1 Ab–mediated endothelial cell damage and platelet dysfunction. To circumvent these potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding region from Japanese encephalitis virus NS1 to create chimeric DJ NS1 protein. Passive immunization of DENV-infected mice with polyclonal anti–DJ NS1 Abs reduced viral Ag expression at skin inoculation sites and shortened DENV-induced prolonged bleeding time. We also investigated the therapeutic effects of anti-NS1 mAb. One mAb designated 2E8 does not recognize the C-terminal region of DENV NS1 in which host–cross-reactive epitopes reside. Moreover, mAb 2E8 recognizes NS1 of all four DENV serotypes. We also found that mAb 2E8 caused complement-mediated lysis in DENV-infected cells. In mouse model studies, treatment with mAb 2E8 shortened DENV-induced prolonged bleeding time and reduced viral Ag expression in the skin. Importantly, mAb 2E8 provided therapeutic effects against all four serotypes of DENV. We further found that mAb administration to mice as late as 1 d prior to severe bleeding still reduced prolonged bleeding time and hemorrhage. Therefore, administration with a single dose of mAb 2E8 can protect mice against DENV infection and pathological effects, suggesting that NS1-specific mAb may be a therapeutic option against dengue disease.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.1601523
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2017
    detail.hit.zdb_id: 1475085-5
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  • 6
    Online Resource
    Online Resource
    Gut and Oral Microbiota, Immunity and Clinical Features in Taiwanese Children with Atopic Dermatitis
    The American Association of Immunologists ; 2018
    In:  The Journal of Immunology Vol. 200, No. 1_Supplement ( 2018-05-01), p. 45.42-45.42
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 200, No. 1_Supplement ( 2018-05-01), p. 45.42-45.42
    Abstract: Atopic dermatitis (AD) is a skin inflammatory disease, characterized by itch, redness, swelling, oozing, thickening or dryness of skin. The condition typically starts from infancy with changing clinical severity in adolescence and adulthood. It bothers not only the health but also quality of life. The interactions between skin microbes and the skin conditions have been implicated in atopic dermatitis. However, the interplay between host immunity, gut and oral microbiota and clinical features in children remains unclear. In this study, we recruited 30 subjects (17 boys and 13 girls) with atopic dermatitis in a medical center in Taiwan. The mean age was 7.11±5.20 years old. The presentation of skin lesions included redness (73.3%), itch (66.7%), dryness (56.7%) and oozing (36.7%). Some of the patients have comorbidities of allergic rhinitis (30%) and asthma (10%). The mean SCORAD index was 55.33±16.96, with an involvement of 52.58±19.35% of body surface area. The mean eosinophil count was 12.01% and the total IgE was 5040.17 IU/mL. The gut and oral microbiomes were analyzed by using 16S rRNA gene and metagenome sequence analyses. Sterptococcal species are the major oral species and Bacteroides species are the major gut species associated with AD in children. Our data suggest that oral and gut microbiota may underlie the clinical features of AD. Further investigations on the interplay of microbiota, immunity and clinical features are warranted.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.200.Supp.45.42
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2018
    detail.hit.zdb_id: 1475085-5
    Location Call Number Limitation Availability
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