In:
The Journal of Dermatology, Wiley, Vol. 49, No. 12 ( 2022-12), p. 1343-1347
Abstract:
Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse drug reaction characterized by extensive epidermal detachment, which is reportedly mediated by drug‐specific cytotoxic CD8 + T cells, inflammatory monocytes, and neutrophils. Besides the skin, TEN often damages other organs, and it remains unknown whether they are mediated by similar pathogenic cells that cause epidermal damage. We experienced a case who developed TEN complicated with vanishing bile duct syndrome. Immunohistological analysis revealed the infiltration of CD8 + T cells, inflammatory monocytes, and neutrophil extracellular trap‐forming neutrophils in the lesions of both the skin and liver with different degree of infiltration of these cells. These data suggest a difference of dominant pathogenic cells between skin and liver of patients with TEN.
Type of Medium:
Online Resource
ISSN:
0385-2407
,
1346-8138
DOI:
10.1111/1346-8138.16576
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2222121-9
Permalink