GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Biology  (3)
  • XA 52094  (3)
  • 1
    Online Resource
    Online Resource
    Expired Air Resuscitation in Paralyzed Human Subjects
    American Physiological Society ; 1957
    In:  Journal of Applied Physiology Vol. 11, No. 2 ( 1957-09), p. 313-318
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 11, No. 2 ( 1957-09), p. 313-318
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1957.11.2.313
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1957
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Forearm blood flow responses to handgripping after local neuromuscular blockade
    American Physiological Society ; 1998
    In:  Journal of Applied Physiology Vol. 84, No. 2 ( 1998-02-01), p. 754-758
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 84, No. 2 ( 1998-02-01), p. 754-758
    Abstract: Dyke, Christopher K., Niki M. Dietz, Robert L. Lennon, David O. Warner, and Michael J. Joyner. Forearm blood flow responses to handgripping after local neuromuscular blockade. J. Appl. Physiol. 84(2): 754–758, 1998.—To test the hypothesis that acetylcholine “spillover” from motor nerves contributes significantly to skeletal muscle vasodilation during exercise, we measured the forearm blood flow responses during attempted handgripping after local paralysis of the forearm with the neuromuscular-blocking drug pipecuronium. This compound blocks postsynaptic nicotinic receptors but has no impact on acetylcholine release from motor nerves. The drug was administered selectively to one forearm by using regional intravenous drug administration techniques in five subjects. Pipecuronium reduced maximum forearm grip strength from 40.0 ± 3.2 kg before treatment to 0.0 kg after treatment. By contrast, drug administration had no effect on maximum voluntary contraction in the untreated forearm (41.3 ± 3.3 vs. 41.4 ± 2.7 kg). During 2 min of attempted maximal contraction of the paralyzed forearm, the forearm blood flow increased from only 3.4 ± 0.8 to 4.8 ± 1.2 ml ⋅ 100 ml −1 ⋅ min −1 ( P 〈 0.05). Heart rate increased from 63 ± 3 to 73 ± 8 beats/min ( P 〉 0.05) during attempted contraction, and only three of five subjects showed obvious increases in heart rate. Mean arterial pressure increased significantly ( P 〈 0.05) from 102 ± 6 to 109 ± 9 mmHg during attempted contractions. When these increases in flow are considered in the context of the marked (10-fold or greater) increases in flow seen in contracting forearm skeletal muscle, it appears that acetylcholine spillover from motor nerves has, at most, a minimal impact on the hyperemic responses to contraction in humans.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1998.84.2.754
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1998
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Differential effects of soluble and particulate guanylyl cyclase on Ca 2+ sensitivity in airway smooth muscle
    American Physiological Society ; 2002
    In:  Journal of Applied Physiology Vol. 92, No. 1 ( 2002-01-01), p. 257-263
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 92, No. 1 ( 2002-01-01), p. 257-263
    Abstract: Maximal relaxation of airway smooth muscle (ASM) in response to atrial natriuretic peptide (ANP), which stimulates particulate guanylyl cyclase (pGC), is less than that produced by nitric oxide (NO) and other compounds that stimulate soluble guanylyl cyclase (sGC). We hypothesized that stimulation of pGC relaxes ASM only by decreasing intracellular Ca 2+ concentration ([Ca 2+ ] i ), whereas stimulation of sGC decreases both [Ca 2+ ] i and the force developed for a given [Ca 2+ ] i (i.e., the Ca 2+ sensitivity) during muscarinic stimulation. We measured the relationship between force and [Ca 2+ ] i (using fura 2) under control conditions (using diltiazem to change [Ca 2+ ] i ) and during exposure to ANP, diethylamine-NO (DEA-NO), sodium nitroprusside (SNP), and the Sp diastereoisomer of β-phenyl-1, N 2 -etheno-8-bromoguanosine-3′,5′-cyclic monophosphorothionate ( Sp-8-Br-PET-cGMPS), a cell-permeant analog of cGMP. Addition of DEA-NO, SNP, or Sp-8-Br-PET-cGMPS decreased both [Ca 2+ ] i and force, causing a significant rightward shift of the force-[Ca 2+ ] i relationship. In contrast, with ANP exposure, the force-[Ca 2+ ] i relationship was identical to control, such that ANP produced relaxation solely by decreasing [Ca 2+ ] i . Thus, during muscarinic stimulation, stimulation of pGC relaxes ASM exclusively by decreasing [Ca 2+ ] i , whereas stimulation of sGC decreases both [Ca 2+ ] i and Ca 2+ sensitivity.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.2002.92.1.257
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2002
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...