In:
European Journal of Organic Chemistry, Wiley, Vol. 2010, No. 11 ( 2010-04), p. 2057-2061
Abstract:
A novel type of pyrrolidine‐based chiral (thio)phosphoramidates was synthesized. Among them, compound ( S ,a R )‐ 3d was proven to be an effective bifunctional organocatalyst for the asymmetric Michael addition of ketones to nitro olefins. The corresponding adducts were obtained in good to excellent chemical yields with high levels of diastereo‐ and enantioselectivities (up to 〉 99:1 dr and 99 % ee ).
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2010:11
DOI:
10.1002/ejoc.201000069
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1410000-9
detail.hit.zdb_id:
1475010-7
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