In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-06-30)
Abstract:
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.25014.001
DOI:
10.7554/eLife.25014.002
DOI:
10.7554/eLife.25014.003
DOI:
10.7554/eLife.25014.004
DOI:
10.7554/eLife.25014.005
DOI:
10.7554/eLife.25014.006
DOI:
10.7554/eLife.25014.007
DOI:
10.7554/eLife.25014.008
DOI:
10.7554/eLife.25014.009
DOI:
10.7554/eLife.25014.010
DOI:
10.7554/eLife.25014.011
DOI:
10.7554/eLife.25014.012
DOI:
10.7554/eLife.25014.013
DOI:
10.7554/eLife.25014.014
DOI:
10.7554/eLife.25014.015
DOI:
10.7554/eLife.25014.016
DOI:
10.7554/eLife.25014.017
DOI:
10.7554/eLife.25014.018
DOI:
10.7554/eLife.25014.019
DOI:
10.7554/eLife.25014.020
DOI:
10.7554/eLife.25014.021
DOI:
10.7554/eLife.25014.022
DOI:
10.7554/eLife.25014.023
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
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