In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-12-19)
Abstract:
Bacteria responsible for the greatest global mortality colonize the human microbiota far more frequently than they cause severe infections. Whether mutation and selection among commensal bacteria are associated with infection is unknown. We investigated de novo mutation in 1163 Staphylococcus aureus genomes from 105 infected patients with nose colonization. We report that 72% of infections emerged from the nose, with infecting and nose-colonizing bacteria showing parallel adaptive differences. We found 2.8-to-3.6-fold adaptive enrichments of protein-altering variants in genes responding to rsp, which regulates surface antigens and toxin production; agr, which regulates quorum-sensing, toxin production and abscess formation; and host-derived antimicrobial peptides. Adaptive mutations in pathogenesis-associated genes were 3.1-fold enriched in infecting but not nose-colonizing bacteria. None of these signatures were observed in healthy carriers nor at the species-level, suggesting infection-associated, short-term, within-host selection pressures. Our results show that signatures of spontaneous adaptive evolution are specifically associated with infection, raising new possibilities for diagnosis and treatment.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.30637.001
DOI:
10.7554/eLife.30637.002
DOI:
10.7554/eLife.30637.003
DOI:
10.7554/eLife.30637.004
DOI:
10.7554/eLife.30637.005
DOI:
10.7554/eLife.30637.006
DOI:
10.7554/eLife.30637.007
DOI:
10.7554/eLife.30637.008
DOI:
10.7554/eLife.30637.009
DOI:
10.7554/eLife.30637.010
DOI:
10.7554/eLife.30637.011
DOI:
10.7554/eLife.30637.012
DOI:
10.7554/eLife.30637.013
DOI:
10.7554/eLife.30637.014
DOI:
10.7554/eLife.30637.015
DOI:
10.7554/eLife.30637.016
DOI:
10.7554/eLife.30637.017
DOI:
10.7554/eLife.30637.018
DOI:
10.7554/eLife.30637.019
DOI:
10.7554/eLife.30637.065
DOI:
10.7554/eLife.30637.066
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
Permalink