Description: Long non-coding RNAs (lncRNAs) participate in the development of breast cancer. Genetic variants in lncRNAs may be involved in their abnormal expressions and associated with cancer risk. In the present study, we performed RNA sequencing on five paired breast cancer tumor and adjacent non-cancerous tissues to obtain differentially expressed lncRNAs. We systematically selected potential regulatory variants of these lncRNAs and investigated the associations between these variants and breast cancer susceptibility in 1,486 breast cancer cases and 1,519 cancer-free controls in a Chinese population. Eleven lncRNAs were significantly differentially expressed between breast cancer tumor and normal tissues (false discovery rate (FDR) 〈 0.05 and fold-change 〉 2), including two known lncRNAs HOTAIR and UCA1 . We subsequently genotyped 20 variants located on these lncRNAs and identified two variants (rs11471161 in AC104135.3 and rs3751232 in RP11-1060J15.4 ) associated with breast cancer risk. Logistic regression analysis indicated that the variant allele of rs11471161 was significantly associated with a decreased breast cancer risk (additive model: OR = 0.84, 95%CI = 0.74–0.94, P = 0.004), while the variant allele of rs3751232 showed an increased risk of breast cancer (additive model: OR = 1.20, 95%CI = 1.02–1.40, P = 0.027). Further co-expression analysis indicated that AC104135.3 associated with ERBB2 , which promotes the development and progression of breast cancer through overexpression. Together, these results suggest that genetic variants rs11471161 and rs3751232 in AC104135.3 and RP11 - 1060J15.4 , respectively, may influence the susceptibility to breast cancer in the Chinese population. Further functional evaluations and larger studies are warranted to validate these findings. This article is protected by copyright. All rights reserved

Description: Neoproterozoic igneous rocks along the northern Yangtze Block are closely related to the evolution of the Rodinia supercontinent. This paper presents zircon U–Pb dating, whole-rock geochemistry and Sr-Nd isotopes of the gabbro–granite association from the Micangshan area, northern Yangtze Block. Zircon LA-ICP MS U–Pb dating indicates that the tonalite and monzogranite from the Pinghe display identical ages of 869 ± 4 Ma (MSWD = 1.3, 2σ) and 859 ± 8 Ma (MSWD = 1.9, 2σ), respectively. According to the regional geology, the gabbro may be younger. The monzogranite and tonalite display almost identical geochemical features, both of them have high Na 2 O/K 2 O ratios, with insignificant negative Eu anomalies, relatively juvenile Sr-Nd isotopic compositions. The monzogranite has initial ( 87 Sr/ 86 Sr)i ratios of 0.703403 to 0.705218, and positive ɛNd( t ) values of +1.23 to +2.98. The tonalite have ( 87 Sr/ 86 Sr)i ratios of 0.700387 to 0.706222, positive ɛNd( t ) values of +1.98 to +7.79, indicating that they were derived from juvenile source. The 860 Ma monzogranite–tonalite association suggests crustal growth event in an active continental margin. The gabbro has low (La/Yb) N ratios (1.80 to 7.61) and total rare earth element contents (∑REE = 44.95 to 83.92 ppm), they have initial ( 87 Sr/ 86 Sr)i ratios of 0.701913 to 0.704815, positive ɛNd( t ) values of +0.65 to +5.73, indicating an island-arc affinity. In combination with the other Neoproterozoic igneous rocks along the western and northern margin of the Yangtze Block, we propose that the gabbro and granitoid association from the Micangshan area represent two stage crustal growth events in the active continental margin setting, and these results imply that the Neoproterozoic crustal growth events in the Yangtze Block may be controlled by subduction.