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  • 1
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 39 (1996), S. 2399-2415 
    ISSN: 0029-5981
    Keywords: boundary elements ; interelement stress ; error bounds ; post-processing ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The conventional boundary element method employs piecewise shape functions which lead to stress discontinuity at the interelement boundary. This paper derives formulae for boundary stress and boundary stress gradient based on boundary element solutions, and discusses error propagation in stress evaluation due to errors in the displacement boundary values. The nature of stress discontinuity is investigated. A simple post-processing scheme is presented using continuities of stress and stress gradient along a traction boundary as two extra conditions, so that a high-order shape function can be employed for the evaluation of stress and stress gradient on the interelement boundary. Four numerical examples are used to demonstrate the accuracy of the proposed post-processing scheme. The numerical results show that as compared with the conventional method, the post-processing method can significantly improve the stress and stress gradient on the traction boundaries, especially in the area of stress concentration.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-07-12
    Description: A method of quantitative analysis of spatial (3D) relationship between discrete nuclear events detected by confocal microscopy is described and applied in analysis of a dependence between sites of DNA damage signaling (γH2AX foci) and DNA replication (EdU incorporation) in cells subjected to treatments with camptothecin (Cpt) or hydrogen peroxide (H 2 O 2 ). Cpt induces γH2AX foci, likely reporting formation of DNA double-strand breaks (DSBs), almost exclusively at sites of DNA replication. This finding is consistent with the known mechanism of induction of DSBs by DNA topoisomerase I (topo1) inhibitors at the sites of collisions of the moving replication forks with topo1-DNA “cleavable complexes” stabilized by Cpt. Whereas an increased level of H2AX histone phosphorylation is seen in S-phase of cells subjected to H 2 O 2 , only a minor proportion of γH2AX foci coincide with DNA replication sites. Thus, the increased level of H2AX phosphorylation induced by H 2 O 2 is not a direct consequence of formation of DNA lesions at the sites of moving DNA replication forks. These data suggest that oxidative stress induced by H 2 O 2 and formation of the primary H 2 O 2 -induced lesions (8-oxo-7,8-dihydroguanosine) inhibits replication globally and triggers formation of γH2AX at various distances from replication forks. Quantitative analysis of a frequency of DNA replication sites and γH2AX foci suggests also that stalling of replicating forks by Cpt leads to activation of new DNA replication origins. © 2013 International Society for Advancement of Cytometry
    Electronic ISSN: 1552-4930
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 3
    Publication Date: 2016-05-18
    Description: The South Yellow Sea (SYS) is a semi-closed epicontinental sea, where voluminous material input and regional tectonic subsidence facilitate preservation of depositional strata, making it an ideal place for studying the regional responses to global sea-level changes during the Quaternary. Based on high-resolution single-channel seismic data, we conducted a detailed study of the SYS shelf in terms of its stratigraphic architecture and seismic facies. In combination with borehole data, we analysed the depositional processes of the SYS shelf since the Quaternary. A minimum of 14 seismic sequences were identified on the seismic profiles, which primarily show four typical seismic reflection facies: progradational reflection facies, parallel reflection facies, chaotic reflection facies and incised valley facies, with the former two seismic facies usually alternating with the latter two vertically. Borehole and seismic data revealed that the SYS shelf has been basically controlled by global sea-level changes since the Quaternary, and three significant transgression events had occurred over the SYS shelf since the Middle Pleistocene ( ca . 730 ka BP–Present), taking place in the early Middle Pleistocene, the early Late Pleistocene and at the end of the Late Pleistocene–Holocene, respectively, with their products corresponding to seismic sequences U90, U50 and U10, respectively. Seismic data showed that, in a previous division of the main boundaries for holes EY02-2, NHH01 and QC2, the Holocene and the Upper Pleistocene bottom boundaries are concordant, while the Middle Pleistocene bottom boundary is discordant, and our study indicated that the division scheme for the Middle Pleistocene bottom boundary related to holes EY02-2 and NHH01 is more reasonable. The turning point of variation in the depositional environment of the SYS is at the end of the Middle Pleistocene, before which global sea-level change and tectonic subsidence controlled the shelf deposition. The shelf was inclined westwards and the tectonic topography of the southern margin of the shelf-forced seawater to invade via passages during sea-level rise. This resulted in a limited stratigraphic distribution formed by short-duration transgression events with low-amplitude sea-level rise; thereafter, the shelf deposition was predominated by global sea-level and rivers, and the shelf sediments were mainly derived from mainland China on the west of the shelf and were primarily accumulated on the middle and western parts of the shelf. Copyright © 2016 John Wiley & Sons, Ltd.
    Print ISSN: 0072-1050
    Electronic ISSN: 1099-1034
    Topics: Geosciences
    Published by Wiley-Blackwell
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  • 4
    Publication Date: 2018-01-28
    Description: This paper presents a design methodology of multisine signals, so that they can be used as phase references or standards convenient for modulated measurements. To achieve an extendable measurement bandwidth, the spectrum of each multisine is designed with three successive segments, where the left (lower-frequency) and right (higher-frequency) ending ones have the same phase spectra. In this way several multisines, one by one overlapped at the ending segments, can jointly serve as an integrated phase reference/standard signal, which in theory has an arbitrarily extendable bandwidth. By the example of “Schroeder” phase relationship, the proposed method is experimentally verified for wideband modulated measurements, where the designed multisines are used as the phase references and standards, respectively, of a nonlinear vector network analyzer test bed. In this work, a phase measurement error less than ±1 deg. is experimentally confirmed for 1601-tone measurements with 160 MHz modulation bandwidth around 2 GHz.
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
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  • 5
    Publication Date: 2017-05-26
    Description: Background Psoriasis is a complex disease that is influenced by both genetic and environmental factors with abnormal gene expression in lesional skin. However, no studies are available on genome-scale gene expression of psoriatic lesions in the Chinese population. In addition, systematic studies on the biological pathways, pathogenicity and interaction networks of psoriasis-related genes with abnormal expression profiles require further investigation. Objectives To further explore the associated pathways in psoriasis by functional analysis and to identify the key genes by gene pathogenicity analysis. Methods We performed RNA sequencing on 60 skin biopsy samples from psoriasis patients and healthy controls to identify the primary differentially expressed genes in psoriatic lesional skin. We retrieved all reported psoriasis-associated genes and performed integrative analyses covering gene expression profiling, pathway analysis, gene pathogenicities and protein-protein interaction networks. Results We found that internal and external stimuli may activate immuno-inflammatory responses to promote the development of psoriasis. Pathways associated with infectious diseases and cancers were identified by functional and pathway analyses. The gene pathogenicity analysis revealed five key genes in psoriasis, including PPARD , GATA3 , TIMP3 , WNT5A and PTTG1 . Conclusions Our analyses showed that genes contributed to the pathogenesis of psoriasis by activating risk pathways with components abnormality in expression. We identified five potentially pathogenic genes for psoriasis that may serve as important biomarkers for the diagnosis and treatment. This article is protected by copyright. All rights reserved.
    Print ISSN: 0007-0963
    Electronic ISSN: 1365-2133
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 6
    Publication Date: 2012-05-30
    Description: The boundary between the upper and lower mantles of Earth corresponds to breakdown of (Mg,Fe)2SiO4, spinel (ringwoodite), into (Mg,Fe)SiO3 perovskite (pv) + (Mg,Fe)O, magnesiowüstite (mw). The rheology of these materials is important for understanding deeply subducted slabs, the termination of deep earthquakes, mantle convection, post-glacial rebound, etc. It has been proposed that decomposition of ringwoodite as subducting slabs enter the lower mantle leads to very fine-grained material that is inherently weak because it flows by grain-boundary sliding. Such abrupt and great weakening would have important geophysical implications. Here we test whether products from such decomposition are weak, using a realistic analogue high-pressure system (Co2TiO4). Our results show that spinel breakdown products are complicated intergrowths (symplectites) that flow by dislocation creep, rather than fine-grained domains that flow by diffusion creep as is commonly assumed from very fine phase domains seen in two dimensions. Application to Earth strongly suggests that ringwoodite breakdown is likely to strengthen the slab, reflecting the inherently greater viscosity of the uppermost lower mantle revealed by geophysical measurements.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
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  • 7
    Publication Date: 2015-05-17
    Description: The impact of sandwich foehn on air pollution in Urumqi, a gap town located on the northern leeside of the Tianshan Mountains of China, is analyzed. The results show that during days with high pollution, the boundary layer over the city and the down-valley area can be divided into a three-layer structure, with the southeasterly foehn sandwiched between the northwesterly winds on top and the cold-air surface pool beneath. The southeasterly foehn at heights between 480 and 2,100 m results in a very stable boundary layer structure. In combination with the decoupling between the foehn flow and cold air pool, such boundary layer structure prevents vertical mixing of atmospheric pollutants. In the up-valley area from the northern leeside flank to the southern urban area, the ground-based foehn confronts the thermally driven valley breeze and forms a “mini-front,” which moves northwards in the morning and retreats southwards in the afternoon. Although the mini-front disappears in the early evening, the wind shear of the mountain breeze between the southern suburb and downtown areas is still remarkable, which is favorable for a convergence line to persist around the city all day long. In this case, air pollutants emitted from the up-valley and down-valley areas are transported toward the urban area. Therefore, the air pollutants accumulate daily, leading to the frequent occurrence of heavy pollution events in Urumqi. This indicates that the sandwich foehn plays a critical role in the formation of heavy air pollution events in Urumqi.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 8
    Publication Date: 2013-11-01
    Description: A case study on a desert-oasis wetland ecosystem in the arid region of Northwest China, measured the seasonal and interannual variation in energy partitioning and evapotranspiration to analyze the response of water and energy exchange on soil moisture, groundwater, and environmental variable. Energy partitioning showed a clear seasonal and inter-annual variability, and the process of water and energy exchange differed significantly in the monthly and interannual scale. The net radiation was 7.31 MJ · m -2  · d -1 , and sensible heat flux accounted for 50.42% of net radiation in energy fluxes, 40.56% for latent heat flux and 9.02% for ground heat flux. The parameters in energy fluxes were best described by a unimodal curve, whereas sensible heat flux followed a bimodal curve. Variations in the daily evapotranspiration and crop evapotranspiration also exhibited a single peak curve with annual values of 569.84 mm and 644.47 mm, respectively. Canopy conductance averaged 20.77 ± 13.75 mm · s –1 and varied from 0.16 mm · s –1 to 83.96 mm · s –1 during the two hydrological years. The variation in water and energy exchange reflected environmental conditions and depended primarily on vapor pressure deficit, net radiation, soil moisture, and water depth. Although the effects of precipitation on evapotranspiration showed that the response of this ecosystem to climate changes was not obvious, the variation of air temperatures had a strong influence on evapotranspiration resulted in a significantly increased in evapotranspiration (R = 0.730; P 〈 0.01) . This article is protected by copyright. All rights reserved.
    Print ISSN: 0885-6087
    Electronic ISSN: 1099-1085
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley-Blackwell
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  • 9
    Publication Date: 2017-02-22
    Description: A new computing method is proposed for reliable analysis. The limit state function is implicit and nonlinear in reliability analysis of slopes and is difficult to apply by traditional reliability methods, especially in large-scale project applications. Relevance vector machines (RVMs) are capable of approximating the limit state function without the need for additional assumptions regarding the function form, as opposed to traditional polynomial response surfaces. RVMs were adapted to obtain the limit state function. We propose an RVM-based response surface method combined with the first-order reliability method for slope reliability analysis and describe its step-by-step implementation. The reliability index obtained from the proposed method shows excellent agreement with traditional response surface method results. Copyright © 2017 John Wiley & Sons, Ltd.
    Print ISSN: 0363-9061
    Electronic ISSN: 1096-9853
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
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  • 10
    Publication Date: 2012-10-06
    Description: SUMMARY This paper proposes a numerical model for jointed rock masses within the 3-D numerical manifold method (NMM) framework equipped with a customized contact algorithm. The strength of rock sample containing a few sets of discontinuities is first investigated. The results of models with simple geometries are compared with the available analytical solutions to verify the developed computer code, whereas models with complex geometries are simulated to better understand the fundamental behavior and failure mechanism of jointed rock mass. Furthermore, the stability of jointed rock mass in an underground excavation is studied, where rock failure process is determined by the 3-D NMM simulation. The simulation results provide valuable guidance on excavation process design and stabilization design in rock engineering practice. Copyright © 2012 John Wiley & Sons, Ltd.
    Print ISSN: 0363-9061
    Electronic ISSN: 1096-9853
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Published by Wiley-Blackwell
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