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  • 1
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    Late Holocene Sea Level Reconstructions Based on Observations of Roman Fish Tanks, Tyrrhenian Coast of Italy (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-04-20
    Description: We present estimates for late Holocene relative sea level change along the Tyrrhenian coast of Italy based on morphological characteristics of eight submerged Roman fish tanks ( piscinae ) constructed between the 1st century B.C. and the 2nd century A.D. Underwater geomorphological features and archaeological remains related to past sea level have been measured and corrected using recorded tidal values. We conclude that local sea level during the Roman period did not exceed 58 ± 5 cm below the present sea level. These results broadly agree with previous observations in the region but contrast with recent analysis that suggests a significantly larger sea level rise during the last 2000 years. Using a glacial isostatic adjustment model, we explain how regional sea level change departs from the eustatic component. Our calculation of relative sea level during the Roman period provides a reference for isolating the long-wavelength contribution to sea level change from secular sea level rise. Precise determination of sea level rise in the study area improves our understanding of secular, instrumentally observed, variations across the Mediterranean. © 2012 Wiley Periodicals, Inc.
    Print ISSN: 0883-6353
    Electronic ISSN: 1520-6548
    Topics: Archaeology , Geosciences
    Published by Wiley-Blackwell
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  • 2
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    A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment (2017)
    Wiley-Blackwell
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    Publication Date: 2017-12-13
    Description: The pharmacological therapy of GH-secreting pituitary tumors is based on somatostatin (SS) analogs that reduce GH secretion and cell proliferation by binding mainly SS receptors type 2 (SST2). Antimigratory effects of SS have been demonstrated in different cell models, but no data on pituitary tumors are available. Aims of this study were to evaluate SST2 effects on migration and invasion of human and rat tumoral somatotrophs, and to elucidate the molecular mechanism involved focusing on the role of cofilin and filamin A (FLNA). Our data revealed that SST2 agonist BIM23120 significantly reduced GH3 cells migration (-22%±3.6%, p〈0.001) and invasion on collagen IV (-31.3%±12.2%, p〈0.01), both these effects being reproduced by octreotide and pasireotide. Similar results were obtained in primary cultured cells from human GH-secreting tumors. These inhibitory actions were accompanied by a marked increase of RhoA/ROCK dependent cofilin phosphorylation (about 2.7-fold in GH3 and 2.1-fold in human primary cells). Accordingly, the anti-invasive effect of the SS analog was mimicked by the overexpression in GH3 cells of the S3D phosphomimetic cofilin mutant, and abolished by both phosphodeficient S3A cofilin and a specific ROCK inhibitor that prevented cofilin phosphorylation. Moreover, FLNA silencing and FLNA dominant negative mutants FLNA19-20 and FLNA21-24 transfection demonstrated that FLNA plays a scaffold function for SST2 mediated cofilin phosphorylation. Accordingly, cofilin recruitment to agonist-activated SST2 was completely lost in FLNA silenced cells. In conclusion, we demonstrated that SST2 inhibits rat and human tumoral somatotrophs migration and invasion through a molecular mechanism that involves FLNA-dependent cofilin recruitment and phosphorylation. This article is protected by copyright. All rights reserved.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 3
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    Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from non functioning pituitary tumors (2017)
    Wiley-Blackwell
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    Publication Date: 2017-01-26
    Description: The role of progenitor/stem cells in pituitary tumorigenesis, resistance to pharmacological treatments and tumor recurrence is still unclear. This study investigated the presence of progenitor/stem cells in non-functioning pituitary tumors (NFPTs) and tested the efficacy of dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists to inhibit their in vitro proliferation. We found that 70% of 46 NFPTs formed spheres co-expressing stem cell markers, transcription factors (DAX1, SF1, ERG1) and gonadotropins. Analysis of tumor behavior showed that spheres formation was associated with tumor invasiveness (OR= 3,96; IC: 1.05-14.88, p=0.036). The in vitro reduction of cell proliferation by DRD2 and SSTR2 agonists (31±17% and 35±13% inhibition, respectively, p〈0.01 vs basal) occurring in about a half of NFPTs cells was conserved in the corresponding spheres. Accordingly, these drugs increased cyclin-dependent kinase inhibitor p27 and decreased cyclin D3 expression in spheres. In conclusion, we provided further evidence for the existence of cells with a progenitor/stem cells-like phenotype in the majority of NFPTs, particularly in those with invasive behavior, and demonstrated that the antiproliferative effects of dopaminergic and somatostatinergic drugs were maintained in progenitor/stem-like cells. This article is protected by copyright. All rights reserved.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 4
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    Greenland uplift and regional sea–level changes from ICESat observations and GIA modeling (2012)
    Wiley-Blackwell
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    Publication Date: 2020-12-14
    Description: We study the implications of a recently published mass balance of the Greenland ice sheet (GrIS), derived from repeated surface elevation measurements from NASA’s ice cloud and land elevation satellite (ICESat) for the time period between 2003 and 2008. To characterize the effects of this new, high-resolution GrIS mass balance, we study the time-variations of various geophysical quantities in response to the current mass loss. They include vertical uplift and subsidence, geoid height variations, global patterns of sea level change (or fingerprints), and regional sea level variations along the coasts of Greenland. Long-wavelength uplifts and gravity variations in response to current or past ice thickness variations are obtained solving the sea level equation, which accounts for both the elastic and the viscoelastic components of deformation. To capture the short-wavelength components of vertical uplift in response to current ice mass loss, which is not resolved by satellite gravity observations, we have specifically developed a high-resolution regional elastic rebound (ER) model. The elastic component of vertical uplift is combined with estimates of the viscoelastic displacement fields associated with the process of glacial-isostatic adjustment (GIA), according to a set of published ice chronologies and associated mantle rheological profiles. We compare the sensitivity of global positioning system (GPS) observations along the coasts of Greenland to the ongoing ER and GIA. In notable contrast with past reports, we show that vertical velocities obtained by GPS data from five stations with sufficiently long records and from one tide gauge at the GrIS margins can be reconciled with model predictions based on the ICE-5G deglaciation model and the ER associated with the new ICESat-derived mass balance.
    Description: Published
    Description: 1457-1474
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: JCR Journal
    Description: restricted
    Keywords: Sea level change ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
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    Mantle viscosity inference: a comparison between Simulated Annealing and Neighbourhood Algorithm inversion methods (2012)
    Wiley-Blackwell
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    Publication Date: 2017-04-04
    Description: Two direct search methods, simulated annealing and neighbourhood algorithm, are applied to the inversion of the viscosity profile of the mantle using relative sea level time-histories for the Hudson Bay region. In problems characterized by a low-dimensional model space (Nd = 2 in this study), the two inversion methods show comparable performances. When a larger number of dimensions is involved (specifically Nd = 6), we directly show that simulated annealing is less effective than neighbourhood algorithm in overcoming the obstacles that are found in the model space when our specific data set is employed. This study confirms that modifications of the conventional Monte Carlo inversion method, such as simulated annealing and neighbourhood algorithm, are viable tools to determine the viscosity profile of the mantle, which, until recently, has been mainly tackled by means of linearized techniques.
    Description: Published
    Description: 890-900
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: JCR Journal
    Description: restricted
    Keywords: mantle viscosity ; simulated annealing ; neighbourhood algorithm ; postglacial rebound ; 04. Solid Earth::04.01. Earth Interior::04.01.03. Mantle and Core dynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 6
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    Isostatic rebound following the Alpine deglaciation: impact on the sealevel variations and vertical movements in the Mediterranean region (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2017-04-04
    Description: The present-day sea level variations and geodetically observed ground deformations in the Mediterranean area are normally ascribed to the combined effect of tectonic or human-driven subsidence and postglacial uplift as a result of the melting of the major Pleistocene ice sheets. However, another potential cause of deformation, only marginally considered to date, is the melting of the glacier that covered the Alps during the last glacial maximum (LGM). The aim of this paper is to predict the long-term sea level variations induced by the melting of both the late-Pleistocene and Alpine ice sheets and compare our results with the relative sea level (RSL) observations available in the Mediterranean region. This task is accomplished solving the sea level equation (SLE) for a spherically symmetric viscoelastic Earth. Our analysis shows that the melting of the Alpine glacier has marginally affected the Holocene sea level variations in the near-field sites in southern France (Marseilles and Roussillon) and the central Tyrrhenian sea (Civitavecchia), and that the RSL predictions are significantly sensitive to the chronology of the remote ice aggregates. The computations, which are performed using a specific mantle viscosity profile consistent with global observations of RSL rise, show that the uplift rate driven by the Alpine isostatic readjustment may account for up to 1/3 of the rates observed at GPS stations in the western portion of the chain. Our results suggest that a thorough modelization of both near- and far-field ice sheets is necessary to gain a better insight into the present-day deformations and sea level variations in the Mediterranean region.
    Description: Published
    Description: 137-147
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: JCR Journal
    Description: restricted
    Keywords: Alpine glacier ; glacial rebound ; mantle viscosity ; sea level variations ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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