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  • 1
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: By treatment of methyl 3β-acetoxy-7β-hydroxy-4,4,14-trimethyl-1-oxo-5α-chol-8-en-24-oate 3 with p-toluenesulfonyl chloride in pyridine methyl 3β-acetoxy-4,4,14-trimethyl-11-oxo 19-norchola-5,7,9-trien-24-oate 1a was synthesized and its structure confirmed by spectral evidence. From 3β-acetoxy-19-norlanosta-5,7,9-trien-11-one 1b the 7-amino derivative 1d, of which was prepared by nitration and selective catalytic hydrogenation (10% Pd/C) of the obtained 7-nitro compound 1c.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-03-14
    Description: Recent in vivo findings suggest that the bone sparing capacity of parathyroid hormone-related protein (PTHrP) in diabetic mice might be due at least in part through targeting a suppressed Wnt/β-catenin pathway in osteoblasts. We here aimed to examine the inhibitory action of a high glucose environment on specific components of the canonical Wnt pathway, and the putative compensatory effects of PTHrP, in osteoblastic cell cultures. Mouse osteoblastic MC3T3-E1 cells and primary cultures of fetal mouse calvaria were exposed to normal (5.5 mM) or high (25 mM) D-glucose (HG), with or without PTHrP (1-36) or PTHrP (107-139) for different times. In some experiments, MC3T3-E1 cells were incubated with the Wnt pathway activators Wnt3a and LiCl, or were transfected with plasmids encoding either a mutated β-catenin that cannot be targeted for degradation or a human PTHrP (-36/+139) cDNA, or the corresponding empty plasmid, in the presence or absence of HG. The gene expression of Wnt3a and low density receptor-like proteins (LRP)-5 and 6, as well as β-catenin protein stabilization and β-catenin-dependent transcription activity were evaluated. Oxidative stress status under HG condition was also assessed. The present data demonstrate that HG can target different components of the canonical Wnt pathway, while β-catenin degradation appears to be a key event leading to inhibition of Wnt/β-catenin signalling in mouse osteoblastic cells. Both PTHrP peptides tested were able to counteract this deleterious action of HG. These in vitro findings also provide new clues to understand the underlying mechanisms whereby PTHrP can increase bone formation. J. Cell. Biochem. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
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  • 3
    Publication Date: 2017-12-13
    Description: BACKGROUND Definitive stereotactic body radiotherapy (SBRT) represents an emerging and debated treatment option for patients with prostate cancer, with potential economic savings and reports of short-term efficacy since 2006. The current study sought to define national trends in definitive prostate SBRT use and determine whether patterns vary by travel distance for treatment. METHODS The National Cancer Data Base identified 181,544 men with localized prostate cancer who were treated with definitive external beam radiotherapy from 2004 through 2012. Joinpoint regression analyzed definitive prostate SBRT trends over time, whereas multivariable logistic regression defined the odds for its receipt by travel distance for treatment. RESULTS Definitive prostate SBRT use increased from 1.8% in 2004 to 5.9% in 2012 ( P for trend 〈.0001), with a joinpoint for increased use noted in 2006 ( P 〈.0001). Higher SBRT use was found to be associated with longer travel distance for treatment, younger age, white race, more affluent zip code of residence, academic treatment center, favorable disease characteristics, and fewer comorbidities (all P 〈.0001). Compared with travel distances 〈25 miles for treatment, travel distances of 25 to 50 miles and 〉50 miles were associated with increasing adjusted odds of receipt of definitive prostate SBRT (1.63 [95% confidence interval, 1.51-1.76] and 2.35 [95% confidence interval, 2.14-2.57], respectively; both P  〈 .0001). CONCLUSIONS Definitive prostate SBRT use increased more than 3-fold since 2004, with a significant increase in use coinciding with early reports of short-term efficacy. Long-distance travel for treatment was associated with greater than twice the odds of receipt of definitive prostate SBRT compared with short-distance travel, suggesting that treatment decisions with unknown long-term clinical implications may be strongly driven by sociodemographic factors. Cancer 2017. © 2017 American Cancer Society .
    Print ISSN: 0008-543X
    Electronic ISSN: 1097-0142
    Topics: Biology , Medicine
    Published by Wiley-Blackwell on behalf of The American Cancer Society.
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  • 4
    Publication Date: 2017-01-25
    Description: ABSTRACT The relationships between the synoptic climatology, large-scale teleconnections and the regional avalanche activity index (RAAI) inferred from tree-rings were evaluated for the Presidential Range in the White Mountains (New Hampshire, USA). During the period 1936–2012, 18 years of regional avalanche activity were compared with the winter-scale prevailing joint temperature/climatic modes (cold/wet (CW), cold/dry (CD), warm/wet (WW) and warm/dry (WW)), the North Atlantic Oscillation (NAO), the El Niño-Southern Oscillation (ENSO), the 500-mbar composite anomaly maps and the ratio of snow from different storm tracks. The total winter snowfall and the NAO negatively correlate with the RAAI. There is also a significant difference in avalanche activity between winters with a NAO under or above −3. Winters of regional avalanche activity were present in the four climatic modes, albeit the ratio of avalanche/non-avalanche years is superior for CW winters compared to the three other modes, as well as for wet winters compared to dry winters. CW, CD and WW winters exhibit a negative NAO anomaly, which is eastbound for the wet years. Cold winters (CW, CD) receive more snow from the Great Lakes, whereas coastal depressions are more important during wet winters (CW, WW). The NAO is an adequate predictor of snowfall, but does not provide information about the storm tracks. On the contrary, the ENSO is poorly correlated with snowfall, but its relationship is significant with the ratio of snow produced by coastal depressions (positive relationship) and Great Lakes storms (negative relationship). These are the first results quantifying the atmospheric circulation – synoptic meteorology – snow avalanche relationships in Northeastern North America.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell
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  • 5
    Publication Date: 2015-05-27
    Description: An aquatic eddy covariance (EC) system was developed to measure the exchange of oxygen (O 2 ) and hydrogen ions (H + ) across the sediment-water interface. The system uses O 2 optodes and a newly developed micro-flow cell H + ion selective field effect transistor; these sensors displayed sufficient precision and rapid enough response times to measure concentration changes associated with turbulent exchange. Discrete samples of total alkalinity and dissolved inorganic carbon were used to determine the background carbonate chemistry of the water column and relate the O 2 and H + fluxes to benthic processes. The ECHOES system was deployed in a eutrophic estuary (Waquoit Bay), and revealed that the benthos was a sink for acidity during the day and a source of acidity during the night, with H + and O 2 fluxes of ± 0.0001 and ± 10 mmol m −2 h −1 , respectively. H + and O 2 fluxes were also determined using benthic flux chambers, for comparison with the EC rates. Chamber fluxes determined in 0.25 h intervals co-varied with EC fluxes but were ∼ 4 times lower in magnitude. This difference was likely due to suppressed pore-water advection in the chambers and changes in the chemistry of the enclosed chamber overlying water. The individual H + and O 2 fluxes were highly correlated in each dataset (EC and chambers), and both methods yielded H + fluxes that could not be explained by O 2 metabolism alone. The ECHOES system provides a new tool for determining the influence of benthic biogeochemical cycling on coastal ocean acidification and carbon cycling.
    Electronic ISSN: 1541-5856
    Topics: Biology , Geosciences
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  • 6
    Publication Date: 2017-01-31
    Description: Important part of the multivariate selection shaping social and interspecific interactions among and within animal species emerges from communication. Therefore, understanding the diversification of signals for animal communication is a central endeavor in evolutionary biology. Over the last decade, the rapid development of phylogenetic approaches has promoted a stream of studies investigating evolution of communication signals. However, comparative research has primarily focused on visual and acoustic signals, while the evolution of chemical signals remains largely unstudied. An increasing interest in understanding the evolution of chemical communication has been inspired by the realization that chemical signals underlie some of the major interaction channels in a wide range of organisms. In lizards, in particular, chemosignals play paramount roles in female choice and male–male competition, and during community assembly and speciation. Here, using phylogenetic macro-evolutionary modeling, we show for the very first time that multiple compounds of scents for communication in lizards have diversified following highly different evolutionary speeds and trajectories. Our results suggest that cholesterol, α-tocopherol, and cholesta-5,7-dien-3-ol have been subject to stabilizing selection (Ornstein–Uhlenbeck model), whereas the remaining compounds are better described by Brownian motion modes of evolution. Additionally, the diversification of the individual compounds has accumulated substantial relative disparity over time. Thus, our study reveals that the chemical components of lizard chemosignals have proliferated across different species following compound-specific directions. Understanding the dynamics of signal diversification is a central endeavor in evolutionary biology. Our study shows that compounds of lizard chemosignals have proliferated across different species following compound-specific directions. Chemical components of lizard chemosignals may evolve following heterogeneous tempo and mode of evolutionary dynamics.
    Electronic ISSN: 2045-7758
    Topics: Biology
    Published by Wiley-Blackwell
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