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  • 1
    Electronic Resource
    Electronic Resource
    Partial hydrogenation of cyclopentadiene over amorphous NiB alloy on α-alumina and titania-modified α-alumina (1998)
    Chichester : Wiley-Blackwell
    Journal of Chemical Technology AND Biotechnology 72 (1998), S. 280-284 
    Details
    ISSN: 0268-2575
    Keywords: supported amorphous NiB alloy ; hydrogenation of cyclopentadiene ; catalytic activity ; crystal support and its modification ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Amorphous nickel-boron alloys supported on α-alumina (NiB/Al2O3) and on titania-modified α-alumina (NiB/TMA) with titania loadings ranging from 1·25 to 10 wt% were prepared by a reductive impregnation method, which resulted in a highly dispersed NiB amorphous alloy on the support. When used as catalysts for partial hydrogenation of cyclopentadiene to cyclopentene in a flow fixed-bed reactor at atmospheric pressure, the NiB/Al2O3 showed higher activity than Ni/Al2O3 and Pd/Al2O3 but the NiB/TMA with 5 wt% of titania loading (NiB/TMA5) showed the highest activity of all for the production of cyclopentene in a temperature range of 80-200°C with 10 g gcat-1 h-1 of cyclopentadiene feed. The maximum yield of cyclopentene was 97% on NiB/TMA5, 92% on NiB/Al2O3, 60% on Ni/Al2O3 and 23% on Pd/Al2O3, respectively. The catalytic stability of the amorphous NiB/TMA5 was also excellent with time on stream. The catalyst samples were characterized by ICP, XRD, XPS, BET, TEM and O2 adsorption. The probable modification mechanism is discussed. © 1998 SCI
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
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    Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-08-24
    Description: The tree shrew is becoming an attractive experimental animal model for human breast cancer owing to a closer relationship to primates/humans than rodents. Tree shrews are superior to classical primates because tree shrew are easier to manipulate, maintain and propagate. It is required to establish a high-efficiency tree shrew breast cancer model for etiological research and drug assessment. Our previous studies suggest that 7,12-dimethylbenz(a)anthracene (DMBA) and medroxyprogesterone acetate (MPA) induce breast tumors in tree shrews with a low frequency (〈50%) and long latency (∼7-month), making these methods less than ideal. We induced mammary tumors in tree shrew ( Tupaia belangeri chinensis ) by injection of lentivirus expressing the PyMT oncogene into mammary ducts of 22 animals. Most tree shrews developed mammary tumors with a latency of about three weeks, and by 7 weeks all injected tree shrews had developed mammary tumors. Among these, papillary carcinoma is the predominant tumor type. One case showed lymph node and lung metastasis. Interestingly, the expression levels of phosphorylated AKT, ERK and STAT3 were elevated in 41-68% of PyMT-induced mammary tumors, but not all tumors. Finally, we observed that the growth of PyMT-induced tree shrew mammary tumors was significantly inhibited by Cisplatin and Epidoxorubicin. PyMT-induced tree shrew mammary tumor model may be suitable for further breast cancer research and drug development, due to its high efficiency and short latency. This article is protected by copyright. All rights reserved.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 3
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    Nonstationary desertification dynamics of desert oasis under climate change and human interference (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-11-07
    Description: Desertification is becoming a major ecological concern in arid and semi-arid regions, especially under climate change. Globally, it is burning up lands for human habitats with a rapidly spreading tendency. Many scientists have been struggling to explore the related mechanisms. Challenges remain in revealing the fundamental principle in terms of desert-oasis interactions that are associated with nonstationary variations. Here we present a theory of desertification dynamics through examining nonstationary effects of climate change and human interference. We hypothesize that such dynamics can be described as the fate and transport of dry air mass continuously generated from desert. We simulate a region in northwestern China and reveal that dynamics of the nonstationary desertification process is subject to interactive impacts from a variety of factors. Our study moves forward the field of desertification studies through initiation of the dynamics and nonstationarity concepts which allow the fundamental mechanism be disclosed.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 4
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    Plume-orogenic lithosphere interaction recorded in the Haladala layered intrusion in the Southwest Tianshan Orogen, NW China (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2016-02-27
    Description: The plume-orogenic lithosphere interaction may be common and important for the generation of large igneous provinces. The information regarding such a process is recorded by the Haladala gabbroic intrusion (~300 Ma), the largest layered ultramafic-mafic intrusion hosting V-Ti magnetite deposits in the Southwest Tianshan Orogen, NW China. The Haladala gabbros exhibit unfractionated chondrite-normalized REE patterns with negative Nb and Ta anomalies and positive Pb anomaly on the primitive mantle-normalized multi-element variation diagram. They are characterized by low initial Sr isotopes, slightly decoupled but high positive bulk-rock ε Nd (t) and ε Hf (t), and high 207 Pb/ 204 Pb and 208 Pb/ 204 Pb relative to 206 Pb/ 204 Pb, delineating a DUPAL signature in the sources. The Haladala gabbros cannot be arc or post-collisional magmatism, given the lack of hydrous minerals and low K contents, respectively. This is further supported by the relatively low oxygen fugacity required for the gradual enrichment of V-Ti magnetite during the magma fractionation, and by an overall anhydrous mantle source suggested by troctolite mineral assemblage (olivine + plagioclase). The emplacement age of the Haladala gabbros is identical to that of the Wajilitag kimberlites in the Tarim's interior, which have been interpreted as the first magmatic expression of the Tarim mantle plume. We thus propose that the Haladala gabbroic intrusion was generated in a hybrid geodynamic setting in which the Southwest Tianshan Orogen was impacted by an upwelling mantle plume. In this sense, the Haladala layered gabbroic intrusion records the early phase of magmatism of the Tarim plume, which was preferentially emplaced in a lithospheric weak zone.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 5
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    Simultaneous assessment of both lung morphometry and gas exchange function within a single breath-hold by hyperpolarized 129Xe MRI (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-05-17
    Description: During the measurement of hyperpolarized 129 Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application. Moreover, acquisition during separate breath-holds will increase the measurement error, because of the inconsistent physiological status of the lungs. Here, we present a new method, referred to as diffusion-weighted chemical shift saturation recovery (DWCSSR), in order to perform both DWI and CSSR within a single breath-hold. Compared with sequential single-breath schemes (namely the ‘CSSR + DWI’ scheme and the ‘DWI + CSSR’ scheme), the DWCSSR scheme is able to significantly shorten the breath-hold time, as well as to obtain high signal-to-noise ratio (SNR) signals in both DWI and CSSR data. This scheme enables comprehensive information on lung morphometry and function to be obtained within a single breath-hold. In vivo experimental results demonstrate that DWCSSR has great potential for the evaluation and diagnosis of pulmonary diseases. We present a new method, referred to as diffusion-weighted chemical shift saturation recovery (DWCSSR), in order to perform both diffusion-weighted imaging (DWI) and chemical shift saturation recovery (CSSR) within a single breath-hold. Compared with sequential single breath-hold schemes (i.e. ‘CSSR + DWI’ and ‘DWI + CSSR’ schemes), the DWCSSR scheme is able to significantly shorten the breath-hold time, as well as to obtain high signal-to-noise ratio (SNR) signals in both DWI and CSSR data. It enables us to obtain comprehensive information on lung morphometry and gas exchange function within a single breath-hold.
    Print ISSN: 0952-3480
    Electronic ISSN: 1099-1492
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 6
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    Three New Hasubanan Alkaloids from Stephania hernandifolia (Willd.) Walp. (2013)
    Wiley-Blackwell
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    Publication Date: 2013-10-17
    Description: Three new hasubanan alkaloids, hernsubanines A–C ( 1 – 3 , resp.), were isolated from the whole plants of Stephania hernandifolia. Their structures were elucidated on the basis of physical and spectroscopic data. In in vitro tests for cytotoxic activity against two human cancer cell lines, A 549 and K 562, compound 1 did not exhibit any cytotoxicity.
    Print ISSN: 0018-019X
    Electronic ISSN: 1522-2675
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 7
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    Three New Coordination Compounds with Neodymium Based on Tetrazole Containing Carboxylic Acid Ligands (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-05-27
    Description: Reactions of three tetrazole containing carboxylic acid ligands, namely, Hpztza, Htzpya, and Hpytza [Htzpya = 3-(5-tetrazolyl)pyridine-1-acetic acid, Hpztza = 5-(2-pyrazinyl)tetrazole-2-acetic acid, Hpytza = 5-(3-pyridyl)tetrazole-2-acetic acid] with NdCl 3 · 6H 2 O under hydrothermal conditions, afforded the complexes [Nd(pztza) 2 (H 2 O) 6 ] · pztza · 3H 2 O ( 1 ), [Nd 2 (tzpya) 2 (H 2 O) 12 ]Cl 4 · 2H 2 O ( 2 ), and [Nd(pytza) 2 Cl(H 2 O) 2 ] ( 3 ). The compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. X-ray diffraction analyses revealed that compound 1 displays a mononuclear structure, 2 shows a dinuclear structure, and 3 features a 1D polymeric chain structure via pytza as linker. Furthermore, the luminescent properties investigated at room temperature in the solid state show that compound 2 has an obvious improvement in its luminescence, when compared to the ligand.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 8
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    Suppression of basic fibroblast growth factor expression by antisense oligonucleotides inhibits neural stem cell proliferation and differentiation in rat models with focal cerebral infarction (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-04-09
    Description: This study is designed to investigate the role of basic fibroblast growth factor (bFGF) antisense oligonucleotide (ASODN) on the proliferation and differentiation of neural stem cells (NSCs) in rat models with focal cerebral infarction (CI). Seventy-five Sprague-Dawlay (SD) rats were randomly divided into the control, sham, middle cerebral artery occlusion (MCAO), MCAO + nonsense oligonucleotide (NODN) and MCAO + ASODN groups. Proliferation and differentiation of NSCs were detected by bromodeoxyuridine (BrdU) and immunofluorescence staining, respectively. ELISA was performed to detect the expressions of endogenous factors that include insulin-like growth factor 1 (IGF-1), glial cell line derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), transforming growth factor-α1 (TGF-α1), bFGF, and nerve growth factor (NGF). Results show significant neurological deficits and focal CI in the MCAO and MCAO + NODN groups. An obvious increase of NSC proliferation, reactive proliferation of astrocytes in CI areas, differentiation of newly proliferated NSCs into mature neuronal cells and expressions of endogenous growth factors exhibited in the MCAO, MCAO + NODN and MCAO + ASODN groups. Compared to the MCAO and MACO + NODN groups, the MCAO + ASODN group showed a significant decrease NSC proliferation and differentiation in CI areas as well as decrease expressions of endogenous growth factors. These findings may offer insight to help us understand more as to how bFGF ASODN can effectively suppress the proliferation and differentiation of NSCs. These findings are expected to help contribute to research for new targets in the treatment of focal CI. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
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  • 9
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    Improving Docosahexaenoic Acid Production by Schizochytrium sp. using a Newly Designed High-Oxygen-Supply Bioreactor (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-05-07
    Description: A sufficiently high oxygen supply is crucial for high-cell-density cultivation of aerobic microorganisms, including Schizochytrium sp. We therefore designed a novel bioreactor enabling high-level oxygen supply, and its relevant process parameters and fermentation-stage characteristics were investigated. The real-time changes of pH and non-oil biomass were monitored as proxies for the consumption of nitrogen and lipid accumulation status, which was firstly applied to divided fermentation process with 3 stages. The experimental results showed that the biomass in this porous-membrane-impeller bioreactor was higher than in conventional bioreactor, while docosahexaenoic acid (DHA) percentage in total lipids was lower than in conventional bioreactor. We subsequently implemented a multi-stage control strategy for the porous-membrane-impeller bioreactor, and the maximum biomass, DHA concentration, DHA percentage in biomass and DHA productivity reached 151.0 g/L, 44.3 g/L, 29.33%, 369.08 mg/(L·h), respectively. This study thus provides a highly efficient and economic bioreactor for the production of DHA by Schizochytrium sp. This article is protected by copyright. All rights reserved.
    Print ISSN: 0001-1541
    Electronic ISSN: 1547-5905
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell on behalf of The American Institute of Chemical Engineers (AIChE).
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  • 10
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    miR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-01-06
    Description: MicroRNAs (miRNAs) are small, non-coding RNAs that participate in the regulation of gene expression. Although many studies have demonstrated the involvement of miR-17-5p in different cancers, little is known to its function in ovarian cancer. In this study, we demonstrated that overexpression of miR-17-5p was able to enhance cell proliferation by promoting G1/S transition of the cell cycle and suppressing apoptosis in ES-2 and OVCAR-3 cell lines, whereas inhibition of miR-17-5p yielded the reverse phenotype. YES1 was identified as a novel target gene of miR-17-5p. Moreover, miR-17-5p was found to directly bind to the 3'UTR of YES1 mRNA and up-regulated its expression. Furthermore, knockdown of YES1 led to the suppression of proliferation and induced cell cycle arrest in ES-2 and OVCAR-3 cells. Ectopic expression of YES1 was able to reverse the effects of miR-17-5p inhibition. Collectively, our results indicated that miR-17-5p might play a role in human ovarian cancer by up-regulating YES1 expression. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
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