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  • Wiley-Blackwell  (24)
  • 1
    Electronic Resource
    Electronic Resource
    Immunogenicity of N-(2-hydroxypropyl) methacrylamide copolymers (1985)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 9 (1985), S. 13-24 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The homopolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) and copolymers of HPMA differing in oligopeptide side chains (-Gly-Gly-OH;-Acap-Phe-OH;-Acap-Leu-HMDA and -Gly-Phe-Tyr-OH) or in their content (1.0, 3.5 and 8.4 mol. % of -Gly-Gly-OH side chains)Abbreviations see appropriate Tables and Figures. were investigated with respect to their ability to induce antibody formation in inbred strains of mice. The dependence on the antigen dose on structure of the side chains and on the genetic background of the immunized organism was defined. It was demonstrated that the specificity of the antibody formed is predominantly directed against oligopeptide side chains though some part of the produced antibody is against hydroxypropyl groups. Haptens, such as arsanilic acid and fluorescein isothiocyanate, modifying the side chains, were used as drug models, and their influence on immunogenicity of HPMA copolymers was tested.The HPMA copolymers can be considered as a possible targetable drug delivery system as conditions were found under which the specific antibodies attached to them can damage the target site.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1985.020091985103
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  • 2
    Electronic Resource
    Electronic Resource
    Enzymatic cleavage of side chains of synthetic water-soluble polymersThe scope of these results was presented on 4th Bratislava International Conference on Modified Polymers, Preparation and Properties. Preprints of Short Commun. I P-15, 1975, and the principle is the object of PV 2958-74 from April 25, 1974 (ČSSR). (1976)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 177 (1976), S. 2833-2848 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Durch direkte Copolymerisation oder durch polymeranaloge Reaktion wurden auf der Basis von Poly[N-(2-hydroxypropyl)methacrylamid] wasserlösliche Copolymere hergestellt, die in Seitenketten farbige Substratgruppen für Chymotrypsin tragen. Substrat war L-Phenylalanin-p-nitroanilid, das über seine Aminogruppe an die endständige Carboxylgruppe der Seitenkette gebunden war. Die Spaltbarkeit des so gebundenen Substrates wurde durch die Michaelis-Konstante, durch die maximale Geschwindigkeit und durch den Prozentsatz an Substrateinheiten ausgedrückt, der für das Enzym zugänglich ist. Hauptsächlich wurde der Effekt der Länge und der chemischen Struktur der Seitenkette untersucht. Es wurde gefunden, daß sie länger als 6 Atome sein muß, daß allgemein die Spaltung durch längere Ketten begünstigt wird. Die ε-Aminocapryl-Gruppe als Seitenkette ist für die Spaltung am günstigsten, Während Seitenketten mit einigen Glycyl-Gruppen obwohl länger weniger günstig sind. Polymere mit einem höheren Gehalt an Substrateinheiten sind besser spaltbar.
    Notes: Water-soluble copolymers based on poly[N-(2-hydroxypropyl)methacrylamide] and bearing in their side chains a chromogenic substrate for chymotrypsin were prepared by direct copolymerization or polymeranalogous reaction. The substrate was L-phenylalanine-4′-nitroanilide linked by its amino group to the terminal carboxylic group of the side chain. The cleavage of the substrate thus bonded, was expressed by means of the Michaelis constant, the maximum velocity, and the percentage of substrate unit accesible to the enzyme. The effect of length and chemical structure of the side chain was investigated in the first place. It was found that the chain must be longer than 6 atoms; longer chains are generally more favourable for this cleavage. The ε-aminocaproyl group provides a chain that is most favourable for the cleavage, whereas chains with several glycyl units, though longer, are less favourable. Polymers with higher content of the substrate units undergo cleavage more readily.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1976.021771003
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  • 3
    Electronic Resource
    Electronic Resource
    In vivo and in vitro immunogenicity of water-soluble haptenated copolymers for mouse and human lymphocytes (1985)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 9 (1985), S. 137-143 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Antibody response to soluble copolymers of N-(2-hydroxypropyl)methacrylamide or N-(2-hydroxyethyl) aspartamide, of different molecular weights and various content of haptenic dinitrophenyl (DNP) groups in side chains, was studied using the plaque method and enzymelinked immunosorbent assay (ELISA).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1985.020091985118
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  • 4
    Electronic Resource
    Electronic Resource
    Hydrophilic polymeric microspheres : Their use in immunological methods (1985)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 9 (1985), S. 125-127 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Hydrophilic polymeric microspheres were prepared by y-radiation initiated copolymerization of 2-hydroxyethyl methacrylate, ethylene dimethacrylate, methylenebisacrylamide and methacrylic acid in aqueous solution with possible addition of special monomers bearing fluorescent or other specific ligand groups. The microspheres were used in detection of different subtypes of immunoglobulin Fc-receptors and complement components receptors as well as in the studies of the process of receptor-mediated phagocytosis. A simple assay for testing the phagocytic activity of peripheral blood leukocytes is proposed for clinical applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1985.020091985116
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  • 5
    Electronic Resource
    Electronic Resource
    Investigation of the aminolysis of p-nitrophenyl esters of (meth)acryloylaminophenoxyacetic acids and their copolymers with N-(2-hydroxypropyl)methacrylamide by 6-aminopenicillanic acid (1989)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 190 (1989), S. 2245-2254 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Copolymers of N-(2-hydroxypropyl)methacrylamide with p-nitrophenyl esters of (meth)acryloylaminophenoxyacetic acids were prepared and characterized. The aminolysis of monomeric and polymeric p-nitrophenyl esters by 6-aminopenicillanic acid was studied. The aminolysis rate was structure-dependent. Acryloyl derivatives were more reactive than methacryloyl derivatives. In both cases, the ortho-derivatives were more reactive than the para-derivatives. This phenomenon can be explained by the formation of an intramolecular hydrogen bond in the ortho-derivatives. The synthetic methods studied are suitable for the binding of biologically active compounds containing an aliphatic amino group to polymeric carriers.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1989.021900925
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  • 6
    Electronic Resource
    Electronic Resource
    Reactive copolymers of N-(2-hydroxypropyl)methacrylamide with N-methacryloylated derivatives of L-leucine and L-phenylalanine, 1. Preparation, characterization, and reactions with diamines (1977)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 178 (1977), S. 2169-2183 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Reactive copolymers of N-(2-hydroxypropyl)methacrylamide (1) with p-nitrophenyl esters of N-methacryloylglycyl-L-leucine (3a), N-methacryloylglycyl-L-phenylalanine (3b), N-methacryloyl-ε-aminocaproyl-L-leucine (7a), and N-methacryloyl-ε-aminocaproyl-L-phenylalanine (7b) (i.e. copolymers 8-11) were synthesized. The polymers thus obtained were characterized by the content of active groups, by intrinsic viscosity [η], and by the rate constant of aminolysis with tert-butylamine in dimethyl sulfoxide. Polymers containing free —NH2 groups were prepared by a polymeranalogous reaction with diamines, predominantly 1,6-hexanediamine. The effect of the copolymer structure, of diamine, and of the reaction conditions on the course of the polymeranalogous reaction was studied.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1977.021780804
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  • 7
    Electronic Resource
    Electronic Resource
    Structure of porous cellulose acetate membranes and a method for improving their performance in reverse osmosis (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 13 (1969), S. 637-657 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Experimental data support the hypothesis that the surface layer of the asymmetric Loeb-Sourirajan type porous cellulose acetate membranes has a heterogeneous microporous structure. A general method is proposed for improving the performance of the above membranes in reverse osmosis, by which product rates are increased without decreasing solute separation. The method consists in pumping pure water past the back side of the membrane under just enough pressure for a sufficiently prolonged period of time; after such pretreatment, the membrane is used in the reverse osmosis experiments in the normal manner with the surface layer facing the feed solution. Back-pressure treatment at 400 psig for 85 hr on preshrunk and normally pressure-treated membranes increases the product rate by over 20% without decreasing solute separation in reverse osmosis experiments at 600 psig with the use of 0.5 wt-% NaCl-H2O feed solutions; with a different sequence of back-pressure treatment, similar results have been obtained in reverse osmosis experiments at 1500 psig also. The compaction effect of a normal membrane and that of a back pressure treated membrane are the same during continuous reverse osmosis operation under 600 psig; the effects of back-pressure treatment on a normal membrane and a compacted membrane are also the same. The pure water permeability data obtained in cyclic experiments show that the smaller pores on the surface layer are opened more than the bigger ones during the back side operation. The probable structural changes taking place in the film during back-pressure treatment are discussed.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1969.070130407
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of medium and matrix composition on diffusivities in charged membranes (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 27 (1985), S. 1382-1384 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260270916
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  • 9
    Electronic Resource
    Electronic Resource
    Poly[N-(2-hydroxypropyl)methacrylamide]. IV. Heterogeneous polymerizationPart III cf.2. (1978)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 70 (1978), S. 109-118 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die Kinetik der radikalischen, heterogenen Polymerisation von N-(2-Hydroxypropyl) methacrylamid wurde in Aceton bei 55°C untersucht. Die Reaktionsordnung, bezogen auf das Monomere (1.6) und auf den Initiator (0,5), deutet auf einen bimolekularen Abbruch und eine kettenverkiirzende hxtragungsreaktion hin. Die Gesamtgeschwindigkeitskonstante der Polymerisation wurde zu 5.6. gefunden. Die Zugabe einer kleinen Menge von Losungsmittel (Methanol) zur Polymerisationsmischung verursachte hohere Polymerisationsgeschwindigkeit und hoheres Molekulargewicht, aber größere Mengen von Losungsmittel erniedrigten beide Grokn. Das Auftreten eines Maximums bei R, und R, in Abhangigkeit von der Monomerkonzentration wurde nach der klassischen Bamford-Jenkins-Theorie diskutiert.
    Notes: Kinetics of radical heterogeneous polymerization of N-(2-hydroxypropyl)methacrylamide was studied in acetone at 55°C. The values of reaction order with respect to the monomer (1.6) and to the initiator (0.5) indicate a bimolecular termination and degradative transfer during the chain growth. The over-all rate constant of polymerization was found to be 5.6.10-4. Addition of a small amount of a solvent (methanol) to the polymerization mixture led to an increased polymerization rate and increased molecular weight of the resulting polymer, but a higher amount of the solvent brought about a decrease of both characteristics. The Occurence of maxima on the dependences of Rp, as well as M̄w on the monomer concentration was interpreted in terms of the classical Bamford and Jenkins theory.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1978.050700110
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  • 10
    Electronic Resource
    Electronic Resource
    Copolymerization of N-ethylacrylamide with N-monosubstituted methacrylamides (1976)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 49 (1976), S. 83-92 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die radikalische Copolymerisation von 14C-markiertem N-Äthylacrylamid mit N-Äthylmethacrylamid, N-2-Hydroxypropyl-methacrylamid und N-Butylmethacrylamid in Dimethylsulfoxid wurde bei 60°C untersucht. Die Copolymerisation von N-Äthylacrylamid mit N-Butylmethacrylamid wurde auch in Dimethylformamid und in Methanol durchgeführt. Die Resultate zeigen, daß die am Amidstickstoff gebundene Alkylgruppe die Reaktivität der untersuchten Verbindungen praktisch nicht beeinflußt. Das Lösungsmittel übt einen etwas stärkeren Einfluß auf die Copolymerisationsparameter aus. Wegen der ähnlichen Struktur der beiden Comonomeren werden die Parameter nur als Folge der verschiedenen Abhängigkeit der Reaktivität des N-Äthylacrylamids und N-Butylmethacrylamids vom Lösungsmittel beeinflußt.
    Notes: The radical copolymerization of 14C-labelled N-ethylacrylamide with N-ethylmethacrylamide, N-(2-hydroxypropyl)methacrylamide and N-butylmethacrylamide in dimethylsulphoxide at 60°C was investigated. The copolymerization of N-ethylacrylamide with N-butylmethacrylamide was also studied in dimethylformamide and methanol. The results show that the structure of the alkyl group bonded to the amide nitrogen does not affect the reactivity of the compounds under investigation to any considerable extent. The solvent exhibits a somewhat stronger influence upon the copolymerization parameters. Because of the similar structure of both comonomers the copolymerization parameters will be affected by the solvent only as a result of the different dependence of the reactivity of N-ethylacrylamide and N-butylmethacrylamide on the character of the medium.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1976.050490107
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