ISSN:
0006-3592
Keywords:
oxygen tension
;
cell distribution
;
hollow-fiber bioreactor
;
magnetic resonance imaging
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
We mapped the distribution of dissolved oxygen and mammalian cells in a hollow-fiber bioreactor (HFBR) using 19F NMR T1 relaxation time imaging measurements on an infused perfluorocarbon probe molecule and diffusion-weighted 1H NMR imaging of water. This study shows how cell density influences dissolved oxygen concentration in the reactor and demonstrates that NMR can play an important role in defining the biochemical engineering parameters required for optimization of HFBR design and operation. © 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 56: 56-61, 1997.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
Permalink
