ISSN:
0749-1581
Keywords:
Sophora griffithii
;
Papilionaceae
;
Griffithine
;
Bisdipiperidine
;
alkaloids
;
2D NMR
;
HOHAHA HeteroCOSY
;
HMBC
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The isolation and structure elucidation of a novel dimeric alkaloid, griffithine, from the leafy shoots of Sophora griffithii Stock (Papilionaceae) is described. The alkaloid possesses a 12-membered ring system formed by the linking of C-10 and C-10′ of the alkaloid with the N-1 and N-1′ atoms, respectively. The structure was established on the basis of extensive 1D and 2D NMR studies. The relative stereochemistry at the chiral centres was determined by NOE difference experiments. 10-Oxosparteine was isolated for the first time from the leafy shoots of Sophora griffithii.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260291102
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